Coaching Center for

GPAT | NIPER-JEE | DRUGS INSPECTOR JOBS | PHARMACIST JOBS

| PEBC | NAPLEX |GRE | TOFEL | IELTS | PTE

Certificate Courses offered

M-PV (Pharmacovigilance) | M-CDM (Clinical Data Management) | M-SAS (Clinical)
M-MC (Medical Coding) | M-RA (Regulatory Affairs) | M-CDM and PV

PHARMACEUTICS 1
MASTERS PHARMA SOLUTIONS, HYDERABAD

MASTERS
CDM DRUGS INSPECTOR

UPSC TSPSC
NIPER-JEE
APPSC
ALL STATES PHARMA JOBS NTA SSC SAS
PHARMACIST GPAT
MEDICAL CODING
REGULATORY AFFAIRS PV
CLINICAL COURSES DRUGS INSPECTOR

MEDICAL DEVICE OFFICER

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PHONE
BS Marketing
(123) 456-789001
LINKEDIN +91 9703541050
Graduation - Upper fifth

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PHARMACEUTICS
TABLET WEIGHT VERIATION
Average weight of tablet Maximum % of difference
allowed
IP USP
80 mg or less 130 mg or less ±10%
80-250 mg 130-324 ±7.5%
More than 250 More than 324 ±5%
MASTERS PHARMA SOLUTIONS, HYDERABAD

mg mg

SOME IMPORTANT SOLVENTS AND THEIR VISCOSITY

Liquid Viscosity (centipoise)
Castor oil 1000
Glycerol 400
Olive oil 1000
Chloroform 0.563
Ethyl alcohol 1.19
Water 1.0019

CARR’S INDEX:

% Compressibility Relative flowability

5 - 15 Excellent
12 -16 good
18 - 21 Fair
23 - 28 Slightly poor
28 - 35 Poor
35 -38 Very poor

PHONE
BS Marketing
(123) 456-789001
Graduation - Upper fifth
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• Surface tension is exhibited by liquids due to force of attraction between

molecules of the liquid. The surface tension decreases with increase in
temperature and vanishes at boiling point.
Interface temperature surface tension in mN. m-1
Water – air 20°c 72.86 ± 0.05
Water – air 21.5°c 72. 75
Water – air 25°c 71.99 ± 0.05

• The methods used to calculate absorption rate constants are:

MASTERS PHARMA SOLUTIONS, HYDERABAD

1. Method of residuals
2. 2. Method of Wagner-Nelson
3. Method of inspection
• Wetting agents act by decreasing the contact angle between the particles
and solvent.

CONDITION OF WETTING:

Contact angle Degree of wetting

θ = 0° Complete wetting or perfect wetting
0< θ <90° High wettability
90°≤ θ≤180° Low wettability
Θ=180° No wetting

BIOPHARMACEUTICAL CLASSIFICATION SYSTEM

Class Solubility Permeability Absorption Drugs
1 High High Well Paracetamol,
absorbed propranolol,
theophylline,
verapamil
2 Low High Variable Phenytoin, nifedipine,
carbamazepine,
Ketoconazole

PHONE
BS Marketing
(123) 456-789001
Graduation - Upper fifth
LINKEDIN
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Analytics App
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3 High Low Variable Acyclovir, atenolol,

captopril, metformin,
ranitidine
4 Low Low Poorly Cyclosporin,
absorbed furosemide, ritonavir,
taxol

PRESERVATIVES USED IN PHARMACEUTICAL FORMULATION:

MASTERS PHARMA SOLUTIONS, HYDERABAD

Nature Example
Acidic Phenol, chlorocresol, sorbic acid,
benzoic acid, boric acid and its salt
Neutral Chlorobutanol, benzyl alcohol
Mercurial Thiomersal, nitromersol
Quaternary ammonium compound Benzalkonium chloride, cetyl
pyridinium chloride

TERMS RELATED TO SOLUBILITY:

Terms Definition
Co-solvency This is the phenomena of adding a
more water miscible solvent in a drug
to increase solubility of drug
Dielectric constant Ratio of electric permeability of the
material to the electric permeability of
free space
Hydro trophy It indicates increase in solubility in
water of various substances due to
presence of large amount of additives
Solubility It determines whether a solute
substance is dissolved in a given
solvent sample or not

PHONE
BS Marketing
(123) 456-789001
Graduation - Upper fifth
LINKEDIN
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Substance Isotonicity in %
Sodium chloride 0.9%
dextrose 5%
Boric acid 1.72%
Potassium nitrate 1.57%

• All body fluids have an osmolarity near 300 mOsm/L. IV fluids (contains
0.9% NaCl or 5 % dextrose are isotonic with osmolarity of 270-300
mOsm/L.
MASTERS PHARMA SOLUTIONS, HYDERABAD

• Parenteral nutrition are intravenous solutions with nutrition given

through central or peripheral vein (central or total parenteral nutrition
TPN, peripheral parenteral nutrition PPN).

• Parenteral nutrition contains: Dextrose (20-70 % for TPN or 5-10 %

for PPN) + Amino acids 2. 15 % + Lipids 20-30 % + Additional
components required for complete nutritional support (vitamin +
Electrolytes as Na, K, Ca, Mg, Cl, acetate, phosphate+ Trace elements as
Cu, Mn, Zn, Cr, Se, Fe + Common additives as insulin, heparin, H2
blocker) + Emulsifier if needed + Sterile water.

PHONE
BS Marketing
(123) 456-789001
Graduation - Upper fifth
LINKEDIN
linkedin.com/in/jes_sanchez DownloadGoogle
"Masters Pharma"
Analytics App
| 2018
for Online/Offline Coaching
Certificate Awarded

www.masterspharma.in