Pharmaceutics

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Coaching Center for

GPAT | NIPER-JEE | DRUGS INSPECTOR JOBS | PHARMACIST JOBS


| PEBC | NAPLEX |GRE | TOFEL | IELTS | PTE

Certificate Courses offered


M-PV (Pharmacovigilance) | M-CDM (Clinical Data Management) | M-SAS (Clinical)
M-MC (Medical Coding) | M-RA (Regulatory Affairs) | M-CDM and PV

PHARMACEUTICS
MASTERS PHARMA SOLUTIONS, HYDERABAD

MASTERS
CDM DRUGS INSPECTOR

UPSC TSPSC
NIPER-JEE
APPSC
ALL STATES PHARMA JOBS NTA SSC SAS
PHARMACIST GPAT
MEDICAL CODING
REGULATORY AFFAIRS PV
CLINICAL COURSES DRUGS INSPECTOR

MEDICAL DEVICE OFFICER

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PHARMACEUTICS
MULTIFUNCTIONAL EXCIPIENTS:
Co-processed excipients Components Claimed benefits
Star Cap 1500 Maize starch, Better flow and low
pregelatinized starch compression force
PanExcea, MC200G MCC-89%, Hydroxy Enable direct
propylene methyl compression with high
cellulose – 2%, speed tableting
Crospovidone- 9%
Pharmatose DCL40 Βeta-lactose95%, High compressibility,
MASTERS PHARMA SOLUTIONS, HYDERABAD

lactitol- 5% low lubricant, sensitivity


Ludiflash Mannitol- 90%, kollidon Rapidly disintegrating,
CL-SF 5%, kollicoat SR mechanically stable
30D- 5% tablets
Pharmaburst 500 Mannitol, sorbitol, Rapidly disintegrating
crospovidone, silica, with superior
aspartame and organoleptic properties
magnesium stearate.
Avicel Ce15 MCC-85%, guar-15% Less grittiness, improved
tablet palatability

EQUATIONS ASSOCIATED WITH PREFORMULATION STUDY OF


DRUGS:
Equations Determination of
Noyes- Whitney Dissolution
BET Surface area
Stokes Sedimentation
Higuchi Release of drug from the granular
matrix
Henderson – Hasselbalch pH
Yongs Properties of surfactant
Arrhenius Stability of drug/ product at room
temperature

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TECHNIQUES USED TO DETERMINE POLYMORPHISM:


Term Name Description
DSC Differential scanning DSC is a thermos
calorimetry analytical technique in
which the difference in
amount of heat required
to increase the
MASTERS PHARMA SOLUTIONS, HYDERABAD

temperature of sample
and reference is
measured as a function of
temperature
XRD X-Ray diffraction XRD is used to
determine the atomic and
molecular structure of
crystal, in which the
crystalline structure
causes a beam of incident
X-rays to diffract into
many specific directions
TEM Transmission electron TEM is a microscopy
microscopy technique in which a
beam of electrons is
transmitted through a
specimen to form an
image
DTA Differential thermal In DTA the material
analysis under study and an inert
reference are made to
undergo identical thermal
cycles, while recording
any temperature

PHONE
BS Marketing
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difference between
sample and reference
NMR Nuclear magnetic NMR is a physical
resonance phenomenon in which
nuclei in a strong
constant magnetic field
are perturbed by a weak
oscillating magnetic field
and respond by
producing an
electromagnetic signal
MASTERS PHARMA SOLUTIONS, HYDERABAD

with a frequency
charecteristic of the
magnetic field at the
nucleus
FTIR Fourier transform FTIR is a technique used
infrared to obtain an infrared
spectrum of absorption or
emission of a solid, liquid
or gas

PHYSIO-CHEMICAL PROPERTIES OF THE DRUG:


Characteristics Measured by
Kinetic properties • Dissolution rate
• Rate of solid-state reaction
• stability
Mechanical properties • Hardness
• Tensile strength
• Compatibility tableting
• Handling flow and blending
Packing properties • Molar volume and density
• Refractive index
• Conductivity electrical and
thermal

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• Hygroscopicity
Spectroscopic properties • Electronic transitions
• Vibrational transition
• Rotational transitions
• Nuclear spin transitions
Surface properties • Surface free energy
• Interfacial tension
• Habit
Thermodynamic properties • Enthalpy (heat constant)
• Heat capacity
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• Entropy
• Thermodynamic activity

SWEETENING AGENTS USED IN PHARMACEUTICAL


FORMULATIONS:
Sweeting agent Approximate quantities of solvent in
per gram of solute
Thaumatin 2000-3000 times
Alitame 2000 times
Neohersperidin dihydrochalcone 1500-1800 times
Sucralose 300 – 1000 times
Saccharin 300-600 times
Acesulfame K 180-200 times
Aspartame 200 times
Glycyrrhizin 50 times
Sodium cyclamate 30 times
Fructose 1.7 times
Sucrose 1 time
Trehalose 0.45 time

PHONE
BS Marketing
(123) 456-789001
Graduation - Upper fifth
LINKEDIN
linkedin.com/in/jes_sanchez DownloadGoogle
"Masters Pharma"
Analytics App
| 2018
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Certificate Awarded

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