TY - JOUR

AU - Bousrez, Guillaume
AU - Jaroschik, Florian
C7 - e202200202
TI - Organic Synthesis with Elemental Lanthanides – Going Beyond Samarium and
Ytterbium
JO - European Journal of Organic Chemistry
JA - Eur. J. Org. Chem.
VL - 2022
IS - 18
SN - 1434-193X
UR - https://doi.org/10.1002/ejoc.202200202
DO - https://doi.org/10.1002/ejoc.202200202
SP - e202200202
KW - Lanthanides
KW - Grignard chemistry
KW - Reduction
KW - Radicals
KW - Transition metals
PY - 2022
AB - Abstract Lanthanide (Ln) metals are strong reducing agents (E0(Ln3+/Ln0)≈?
2.3?V vs. NHE) which can be applied in various manners in organic synthesis. While
samarium and ytterbium have been employed for more than 50?years, the last 20?years
have seen the emergence of synthetic applications using other metals, such as
lanthanum, cerium, praseodymium, neodymium or dysprosium. The large electron
reservoir of lanthanide metals, the Lewis acidic character of the Ln3+ ions and
their intermediate electronegativity compared to lithium or magnesium can provide
unique reactivity patterns. This review provides an overview on the potential of
these metals for synthetic organic chemistry in the following areas: 1) for
Grignard type reactivity and radical generation, 2) in reduction chemistry
involving carbonyl compounds and dehalogenation reactions and 3) in combination
with transition metals.
ER -