Chromosomes And DNA

1. Sequence remains conserved in,

a. Semi-Conservative
b. Conservative
c. Dispersive
d. All
2. Which polymerase is used in general replication,
a. I
b. II
c. III
d. Both a and c
3. Which forms phosphodiester bond,
a. Ligase
b. Primase
c. DNA Polymerase
d. All
4. Anticodon is similar to
a. Template strand
b. Coding strand
c. Both
d. None
5. Stops Transcription,
a. Stop Codon
b. Stop Sequence
c. Hair pin
d. None
6. 1st genetic codon attaches at,
a. P-site
b. A-site
c. E-site
d. None
7. Initiation complex is made up of
 a. mRNA,tRNA
b. mRNA,tRNA,smaller ribosomal subunit
c. mRNA,tRNA,larger ribosomal subunit
d. mRNA,tRNA,ribosome
8. Nonsense codon binds to __ during translation
a. mRNA
b. tRNA
c. Both
d. Do no attaches
9. AGG reads ___ in mitochondria
a. Methionine
b. Tryptophan
c. Isoleucine
d. None
10. Gene transposition is,
a. Point mutation
b. Chromosomal aberration
c. Both
d. None
11.Which of the following is the third level of organization of chromosomes?
A)Supercoil
B)Nucleosome
C)Chromatin
D)Coil
12.No of peaks observed by Matthew meselson & Stahl during 2nd round of replication?
A)1
B)3
C)4
D)2
13.Which is not present in DNA poly III?
A)Beta 2
B)T1
C)Beta 1
D)Theta
14.In Sickle Cell Anemia, which is replaced by thymine?
A)Guanine
B)Cytosine
C)Adenine
D)Uracil
15.No different sites on tRNA molecule?
A)2
B)1
C)3
D)4
16.How many genetic codes are present with same arrangement of nucleotides?
A)1
B)3
C)4
D)2
17.Which is chromosomal aberration?
A)Addition
B)Transposition
C)Deletion
D)Insertion
18.Peptide bond formation b/w successive amino acids is done by?
A)Small ribosomal subunit
B)Large ribosomal subunit
C)Elongation Factor
D)Leader sequence
19.Chances of a 45 years old mother to give birth to Down Syndrome infected individual?
A)1/100
B)1/1000
C)3/100
D)1/50
20.Which of the following has a low frequency of births?
A)Edward
B)Patau
C)Turner
 D)Down

Chromosomes and DNA

21)Chromosomes acquire different shapes at which phase of cell division?
a)Metaphase
b)Anaphase
c)Prophase
d)Telophase

22)Structural unit of chromatin material is;

a)DNA
b)Chromosomes
c)Nucleotide
d)Nucleosomes

23)Which one of the following prepared DNA fibers?

a)Rosalind Franklin
b)Maurice Wilkins
c)James Watson
d)Meselson

24)Backbone of DNA duplex is made up of?

a)Nitrogenous bases and phosphate group
b)Pentose sugar and phosphate group
c)Nitrogenous bases and Pentose sugar
d)None of these

25)DNA replication occurs in;

a)Mitochondria
b)Nucleus
c)Chloroplasts
d)All of these

26)Transcription bubble move on template strand in;

 a)5--->3
b)5--->5
c)3--->5
d)3--->3

27)First tRNA molecule binds at mRNA during translation at which site?

a)A-site
b)P-site
c)E-site
d) All of these

28)Sickle cell anemia is a mutation that replaces;

a)A with T
b)T with A
c)G with C
d)C with G

29)In which one of the following syndromes 21st pair of chromosomes fails to segregate?
a)Klinefelter's syndrome
b)Turner's syndrome
c)Jacob's syndrome
d)Down's syndrome

30)Which one of the following is not a symptom of Down's syndrome?

a)Broad Face
b)Enlarged Breast
c)Mental retardation
d)Protruding tongue

31) The term chromosome was coined by

a) Ernst haeckel
b) Frederick Miescher
c) Walther flemming
d) Schwann
32) Which of the following human cell contains 23 chromosomes
a) Zygote
b) Skin cell
c) Liver cell
d) Ovum

33) What is the haploid number of chromosomes in mosquito

a) 4
b) 6
c) 3
d) 12

34) A pair of a morphological is similar chromosome is called

a) Homologous chromosomes
b) Heterologous chromosomes
c) X and y chromosome
d) A and C

35) Harshey and chase used radioactive __ to label DNA code of bacteriophage
a) Phosphorus
b) Nitrogen
c) Sulphur
d) Carbon

36) In sickle cell anaemia glutamic acid is replaced by

a) Theonine
b) Valine
c) Leucine
d) Histidine

37) The rungs of ladder ( DNA )are made of

a) Deoxyribose sugar
b) Hydrogen-bonded bases
 c) Phosphate groups
d) Ribose sugar

38) RNA polymerase use ___as a template to synthesise ___

a) RNA ,protein
b) RNA ,DNA
c) DNA ,RNA
d) DNA ,protein

39) If a sequence of 2 nucleotide is used then it will only code for __ amino acid
a) 8
b) 16
c) 44
d) 64

40) Codon is present in

a) mRNA
b) rRNA
c) tRNA
d) All

41) Histones are

A)Positively charges
B)Negatively charged
C)Neutral
D)Partial positively charged

42) The result of using heat-killed pathogenic strain of S.pneumonia was

a) Mice live
b) mice die
c) mice develop the symptoms
D) none

43) A second nucleotide attaches at which position of first nucleotide

 a) C-1
b) C-3
c) C -4
d) C-5

44) The base pairs are ______ apart

a) 0.34nm
b)3.4nm
c) 0.34 Angstrom
d) 34 Angstrom

45) In the Meselson-Stahl experiment after the 1st round of replication , which model of DNA
replication was rejected ?
a) Conservative
b) Semi-conservative
c) Dispersive
d) Both A & C

46)What time will DNA polymerase 3 take to jump towards the replication fork after constructing
an Okazaki fragment in a prokaryotic cell?
a) 1-2 seconds
b)5-10 seconds
c) 10-15 seconds
d) 0.01 -0.02 seconds

47) when polymerase reaches ____ end of lagging strand , DNA ligase attaches the fragments to lagging
strand.
a) 5’ end
b)Either 5 or 3
c)3’ end
d) none
48) In urine of alkaptonuria patients , _______ is present
a) Galacturonic acid
b) Homogentisic acid
 c) Heterogentisic acid
d) oleic acid
49) The attachment of amino acid with t-RNA is accompanied by
A) Removal of NH2 Group
b) the product is a addition product with no removal
c) removal of H2O molecule
d) Conversion of COOH to CHO

50) Edward Syndrome is an example of _____

a) 21 trisomy
b) 18 trisomy
c) 13 trisomy
d) 17 trisomy
51- The stop signal GC series of base pairs is the part of :
a- DNA
b- mRNA
c- tRNA
d- rRNA

52- Central dogma is:

a- DNA replication---> Transcription---> Translation
b- DNA---> tRNA---> Protein
c- RNA----> DNA----> Protein
d- rRNA---> DNA----> Translation

53- Mutation occurs at position __ and alters ___ structure of haemoglobin

a- 4, quaternary
b- 5, secondary
c- 6, quaternary
d- 6,tertiary
54- XXY is known as
a- Down's syndrome
b- Jacob's syndrome
 c- Klinefelter's syndrome
d- Turner's syndrome

55- Ferns have more than ___ pairs of chromosomes

a- 400
b- 500
c- 600
d- 300

56- Which pair has similar no. of chromosomes

a- Frog, Corn
b- Human, Chimpanzee
c- Chimpanzee, potato
d- sugarcane, potato

57- Autosomal Non- disjunction is___ and nondisjunction appears to occur in____
a- Klinefelter , ova
b- Down's , Ova
c- Turner's , sperm
d- Down's , sperm

58- In Sickle cell anemia, infected haemoglobin chains are

a- Both Alpha
b- One Alpha, one beta
c- Both Alpha and beta chains
d- both Beta chains

59- The disease in which urine turned black due to presence of ___ acid is ___
a- Hydrochloric acid, sickle cell anemia
b- Homogenisitic acid, phenylketonuria
c- Homogenisitic acid, Alkaptonuria
d- homogentisic acid, Mongolism

60- Beadle and tatum exposed Neurospora spores to

 a- X- rays
b- beta - rays
c- Alpha- rays
d- Gamma- rays
61-The smallest type of RNA is
A) tRNA mRNA C) rRNA D) genetic RNA
62-The double stranded helical structure of DNA is maintained by
A) amide bonds B) H-bonds C) covalent bonds D) phosphodiester bonds
63-Adenosine is
A) nucleoside B) nucleotide C) a purine D) a pyrimidine
64-Short stature, webbed neck, complete absence of germ cells, person is suffering from:
A)Patau syndrome B)Turner syndrome
C)Down's syndrome D)Klinefelter syndrome
65-RNA polymerase II synthesizes:
A) rRNA B)tRNA C) mRNA D) cDNA
66-in eukaryotes, the two RNA polymerase binding sites are:
A)-25 & -10 B)-25 & -75 C)-35 & -10 D)-35 &-70
67-Adenosine diphosphate contains __- high-energy bond(s):
A) One B) Two C)Three D) Four
68-. RNA is synthesized on
A) both strands of DNA B) on sense strand of DNA
C) on antisense strand of DNA D) on cDNA
69-In E. coli DNA has 18% of bases of cytosine. What will be the fraction of adenine?
A) 18% 32% C) 36% D) data insufficient
70-The following conditions are caused by nondisjunction except:
A)Phenylketonuria C)Down's syndrome
B)Patau's syndrome D)Edward's syndrome
 KEY
01.D 11.A 21-B 31) C 41 A 51- A 61-A
02.D 12.D 22-D 32) D 42 A 52- A 62-B
03.D 13.C 23-B 33) C 43 B 53- D 63-A
14.C 24-B 34) A 44 A 54- C 64-B
04.A
15.D 25-D 35) A 45 A 55- B 65-C
05.B
16.C 26-C 36) B 46 A 56- C 66-B
06.B 17.B 27-B 37) B 47 A 57- B 67-A
07.B 18.B 28-B 38) C 48 B 58- D 68-C
08.D 19.C 29-D 39) B 49 C 59- C 69-B
09.D 20.B 30-B 40) A 50 B 60- A 70-A

10.B