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A number of active pharmaceutical ingredients in the
Non-traditional methods of insulin delivery
drug development pipelines are prepared in the
like insulin state
pumps, insulin inhalers and
O
amorphous in light of their poor aqueous
insulin pens have obvious advantages over
solubility (1). In addition, many pharmaceutical
excipients exist
traditional in the amorphous
methods of deliverystate, or are et
(Patni rendered
al.,
amorphous in order to obtain the desired functionality
2006).
(2).
Another promising non-traditional
alternative is the delivery of insulin through
skin. However, human skin provides a very
References
efficient transport
1. C. W. Pouton. barrier
Formulation of poorly APA
(Monteiro-
water-soluble
drugs for oral administration: physicochemical
Riviere, 1991) and (Monteiro-Riviere, 1996) and
physiological issues and the lipid MLA formulation
to delivery of protein molecules like insulin,
classification system. Eur. J. Pharm. Sci. 29:278 287
due to doi:10.1016/j.ejps.2006.04.016.
(2006). their large size (>3000 Da) and
weakly hydrophobic
2. W. Wang. Instability,nature.
stabilization and formulation
of liquid protein pharmaceuticals. Int. J. Pharm.
185:129 188 (1999). doi: 8-5173(99)00152-0.
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doi

O Lackritz E.M. et al., 1995. Estimated risk of

transmission of the human immuno deficiency virus by
screened blood in the United States. N Engl J Med,
doi:10.105612283332601
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According to Colluzzi and Pappagallo as cited

by Holding et al (7) most patients given opiates
do not become addicted to such drugs.
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