Antigenic variation

Single Flagellum

Variable surface glycopreotin coats

Features
Found in streams

gambiense
Slowing progressin (chronic
Infection)
Two species

found in woodlands antelope reservoir

rhodesiense
Severe, acutely fatal

vector for
Transmission Tsetse fly
trypanosomiasis

Causige agent of sleeping

sickness

Trypanosoma 1. Blood Stage

Life Cycle

brucei Diseases
Trypanosomal
2. Febrile Stage

1 stage chancre develop at

3. Intermitent fever
site of inculations

Cervical & axillary

lymphadenopathy

2 stage Daytime sleepiness

Seen on blood smear

Lab Dx.
CSF analysis

Prevention Control fly population aerial insecticides

1 stage Serum-suramin
T.b. rhodesiense
2 stage Melarsoprol Highly toxic
Tto
1 stage Pentamidine

T.b. gambiense
NECT (nifurtimox-eflornithine combination
2 stage
therapy)