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Vasopressin PHARMACOLOGY
Oct 31, 2021 • Download as PPTX, PDF
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Desmopressin
Lypressin… Read more

P PARUL UNIVERSITY

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Vasopressin PHARMACOLOGY
1. VASOPRESSIN Dr. S P SRINIVAS NAYAK, PharmD, RPh, (MSc), (PGDND) (PhD) ASSISTANT PROFESSOR, DEPT. OF PHARMACY
PRACTICE, PU.
2. • Vasopressin an arginine vasopressin (AVP) • Also called as antidiuretic hormone (ADH) • It is a peptide hormone synthesized in
the supraoptic and paraventricular nuclei of the hypothalamus and stored in posterior pituitary VASOPRESSIN
3. Sunday, October 31, 2021 PIPR, PARUL UNIVERSITY
4. VASOPRESSIN RECEPTORS RECEPTOR V1 V2 V3 LOCATION of Vasopressin Receptors and ACTIONS of Vasopressin upon receptor
activation Blood vessels: Vasoconstriction GIT: Increases peristalsis Liver: Glycogenolysis Platelets: Aggregation CNS: Release of
ACTH from anterior pituitary Renal tubules: Increases water reabsorption, hence reduces urinary output Vascular endothelium:
Release of clotting factor VIII and von Willebrand’s factor from vascular endothelium Anterior pituitary: Releases ACTH, prolactin,
endorphins Uterus: Contraction of the smooth muscle by vasopressin is mediated through oxytocin receptors.
5. VASOPRESSIN ANALOGUES Desmopressin Lypressin Terlipressin Felypressin Argipressin ornipressin Sunday, October 31,
2021 PIPR, PARUL UNIVERSITY
6. VASOPRESSIN ANALOGUES ● Desmopressin: It is a selective V2-receptor agonist and is more potent than vasopressin as an
antidiuretic. ● It has negligible vasoconstrictor action. It is administered by oral, nasal and parenteral routes.
7. USES OF DESMOPRESSIN ● USED IN Haemophilia and von Willebrand’s disease: Desmopressin, administered intravenously,
controls bleeding by increasing factor VIII and von Willebrand’s factor. ● Primary nocturnal enuresis: Administration of
desmopressin at bedtime reduces nocturnal urine volume.
8. ● Neurogenic diabetes insipidus (DI): Desmopressin is the drug of choice. ● DI is a condition characterized by excretion of large
volume of urine either due to ● Neurogenic DI: Decreased secretion of ADH from the neurohypophysis or due to ● Nephrogenic DI:
inadequate renal tubular response to ADH. ● OTHER DRUGS TO REMEMBER: ● Thiazides are useful for both central and nephrogenic
DI. ● Amiloride is used for the treatment of lithium-induced nephrogenic DI. ● Indomethacin reduces urine volume in nephrogenic
DI by inhibiting renal prostaglandin synthesis.
9. ● Lypressin: It acts on both V1 and V2 receptors. It is less potent but longer acting than vasopressin. It is administered
parenterally.
10. ● Terlipressin: It is a prodrug of vasopressin with selective V1 action. It is administered intravenously. ● USAGE: ● For
emergency control of bleeding oesophageal varices: ADH controls bleeding by constricting mesenteric blood vessels.
11. ● Felypressin: It is a synthetic analogue of vasopressin. It is mainly used for its vasoconstrictor (V1) action along with local
anaesthetics to prolong the duration of action. Felypressin should be avoided in pregnancy because of its oxytocic (uterine
stimulant) activity.
12. ADVERSE EFFECTS ● Nausea, vomiting, diarrhoea, belching and abdominal cramps. ● Backache is due to uterine contraction. ●
Intranasal administration may cause local irritation and ulceration. ● Fluid retention and hyponatraemia can occur.
13. THANK YOU

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