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The Science of
Paediatrics
MRCPCH Mastercourse
This page intentionally left blank
The Science of
Paediatrics
MRCPCH Mastercourse
Editor
Tom Lissauer
MB BChir FRCPCH
Honorary Consultant Paediatrician, Imperial College Healthcare Trust, London, UK

Deputy editor
Will Carroll
MD MRCP MRCPCH BM BCh BA MA(Oxon)
Consultant Paediatrician, University Hospital of the North Midlands, Stoke-on-Trent, UK

Associate editors
Robert Dinwiddie
MB ChB FRCP FRCPCH DCH
Formerly Consultant Paediatrician, Great Ormond Street Hospital for Children, London, UK

Michael Hall
MB ChB FRCP FRCPCH DCH
Consultant Paediatrician, Princess Anne Hospital, Southampton
Senior Clinical Lecturer, University of Southampton, Southampton, UK

Foreword by
Neena Modi
MB ChB MD FRCP FRCPCH FRCPE
President of the Royal College of Paediatrics and Child Health, UK;
Professor of Neonatal Medicine, Imperial College London, London, UK

EDINBURGH LONDON NEW YORK OXFORD PHILADELPHIA ST LOUIS SYDNEY TORONTO 2017
© 2017, Royal College of Paediatrics and Child Health.

No part of this publication may be reproduced or transmitted in any form or by any means,
electronic or mechanical, including photocopying, recording, or any information storage and
retrieval system, without permission in writing from the publisher. Details on how to seek
permission, further information about the Publisher’s permissions policies and our arrangements
with organizations such as the Copyright Clearance Center and the Copyright Licensing Agency,
can be found at our website: www.elsevier.com/permissions.
This book and the individual contributions contained in it are protected under copyright by
the Publisher (other than as may be noted herein).

Notices
Knowledge and best practice in this field are constantly changing. As new research and experience
broaden our understanding, changes in research methods, professional practices, or medical
treatment may become necessary.
Practitioners and researchers must always rely on their own experience and knowledge in
evaluating and using any information, methods, compounds, or experiments described herein. In
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precautions.
To the fullest extent of the law, neither the Publisher nor the authors, contributors, or editors,
assume any liability for any injury and/or damage to persons or property as a matter of products
liability, negligence or otherwise, or from any use or operation of any methods, products,
instructions, or ideas contained in the material herein.

ISBN: 978-0-7020-6313-8

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 Contents

Foreword, ix
Preface, xi
List of Contributors, xiii

1. The role of science and research in paediatrics, 1

Neena Modi, Anil Mehta
2. Epidemiology and public health, 9
Premila Webster, Sarah Rayfield
3. History and examination, 27
Will Carroll, Simon Li, Ian Petransky
4. Normal child development, 45
Nadya James
5. Developmental problems and the child with special needs, 61
Hayley Griffin, Katherine Martin, Nadya James
6. Paediatric emergencies and critical care, 79
Lynn Sinitsky, Michael Marsh, David Inwald
7. Accidents and poisoning, 101
Mark Anderson, Eleanor Dawson
8. Child protection, 119
Kerry Robinson, Alice J Armitage, Deborah Hodes
9. Genetics, 141
Richard H Scott, Shereen Tadros
10. Perinatal medicine, 157
Mithilesh Kumar Lal, Nazakat Merchant, Sunil K Sinha
With contributions by Helen Yates, Lawrence Miall, Steve Byrne
11. Neonatal medicine, 179
Mithilesh Kumar Lal, Nazakat Merchant, Sunil K Sinha
With contributions by Shalabh Garg
12. Growth and puberty, 217
John W Gregory v
 13. Nutrition, 233
Mary Fewtrell
With contributions by Hannah Tobin
14. Gastroenterology, 253
Huw Jenkins, Lisa Whyte
Contents

With contributions by Toni Williams

15. Infection and immunity, 277

Christine E Jones, Manish Sadarangani, Graham Davies
With contributions by Mike Sharland, Omendra Narayan, Daniel Langer, Christian Harkensee,
Chris Barton, Kirsty Le Doare, Aubrey Cunnington

16. Allergy, 297

John O Warner, Paul J Turner

17. Respiratory medicine, 317

Will Carroll, Warren Lenney

18. Cardiology, 341

Robert M R Tulloh, Jessica Green

19. Nephrology, 365

Rajiv Sinha, Stephen D Marks
20. Genital disorders, 391
Daniel Carroll, Charlotte Slaney
With contributions by John Gregory
21. Hepatology, 403
Deirdre Kelly, Nicola Ruth
22. Oncology, 421
Daniel Morgenstern, Rachel Dommett
23. Haematology, 441
Irene A G Roberts, David O’Connor
24. Child and adolescent mental health, 463
Max Davie, Jacqui Stedmon
25. Dermatology, 479
Nicole Y Z Chiang, Timothy H Clayton
26. Diabetes and endocrinology, 499
John W Gregory
27. Musculoskeletal disorders, 521
Mary Brennan, Helen Foster, Flora McErlane, Rajib Lodh, Sharmila Jandial
28. Neurology, 543
Gary McCullagh, Dipak Ram, Nadya James
29. Metabolic medicine, 571
Elisabeth Jameson
30. Ophthalmology, 589
Louise Allen

31. Hearing and balance, 609

vi Kaukab Rajput, Maria Bitner-Glindzicz
32. Adolescent medicine, 627
Nwanneka N Sargant, Lee Hudson, Janet McDonagh
33. Global child health, 641
Dan Magnus, Anu Goenka, Bhanu Williams
34. Palliative medicine, 659
Richard D W Hain
With contributions by Megumi Baba, Joanne Griffiths, Susie Lapwood, YiFan Liang, Mike Miller
35. Ethics, 673
Joe Brierley
36. Pharmacology and therapeutics, 687
Elizabeth Starkey, Imti Choonara, Helen Sammons
37. Clinical research, 703
Simon Bomken, Josef Vormoor
38. Statistics, 723
Miriam Fine-Goulden, Victor Grech
39. Evidence-based paediatrics, 739
Bob Phillips, Peter Cartledge
40. Quality improvement and the clinician, 757
Peter I Lachman, Ellie Day, Lynette M Linkson, Jane Runnacles

Index, 771

vii
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This book is a welcome addition to the publications
from the Royal College of Paediatrics and Child
Health. It provides background material for trainees
undertaking the ‘Theory and Science’ component of
the MRCPCH examinations. I hope that it will also be
widely read by paediatricians and other health profes-
sionals involved in caring for children, as it provides
a wealth of information on the scientific basis of clini-
cal paediatrics.
Good medical practice that is effective and safe
requires constant nourishment from a pipeline that
leads from discovery and evidence generation, through
implementation to evaluation. Each of these elements
is important; discovery may be targeted (such as inter-
national collaboration to crack the human genome)
or serendipitous (such as the discovery of penicillin),
but without successful implementation, discovery is
barren, and without evaluation we cannot be certain
Foreword
that an intervention is effective and safe. Medicine as
a science recognizes absolute proof, or truth, to be an
illusion and instead focuses attention on reducing
uncertainty. Hence the principle of the null hypothe-
sis, and the objective to attempt to reject it that is the
basis of scientific rigour. This book offers insight into
the building blocks of scientific advancement, as well
as the excitement.
I am very pleased to have been involved in the
genesis of this book. It is innovative and original in
assisting the reader to apply the principles of science
to paediatric practice, and in conveying the messages
of science to our patients and their parents. It will
inform and enlighten, and stimulate you to contribute
to the advance of paediatrics.
Professor Neena Modi
President, Royal College of Paediatrics and Child Health
ix
This page intentionally left blank

Learn from yesterday, live for today, hope for tomorrow. The important
thing is not to stop questioning.
This book, The Science of Paediatrics: MRCPCH Master-
course, is about the application of science to paediatric
clinical practice. It is not about the underlying basic
science, such as biochemistry and the structure and
action of cells, which is covered in undergraduate
medical school. Instead, it is about how we can suc-
cessfully apply that science in everyday paediatric care.
The book has been designed to cover the curriculum
of the MRCPCH Theory and Science examination. It
is the culmination of many requests to provide back-
ground preparation for the exam. Our aim is to fill the
gap between the basic science of undergraduate
medical school and its application to paediatrics.
Some paediatricians have questioned us about the
need for in-depth knowledge about science in clinical
practice. Yet we believe that in order to achieve and
maintain excellence it is essential to adopt a scientific
understanding of all that we do, whether it is interpret-
ing clinical signs or investigations, prescribing drugs
or identifying the best management for our patients.
Indeed, separating science from clinical practice is arti-
ficial and often unhelpful, and it is this division that
we struggled most with in the preparation of this
book.
We all wish to provide the best possible care for our
patients. Yet paediatricians have been responsible for
advocating practices that have turned out to be
harmful, such as the recommendation that babies lie
prone when sleeping, which substantially increased
the risk of sudden infant death syndrome, or uncon-
trolled oxygen therapy for preterm babies, causing
retinopathy of prematurity. These have resulted from
lack of scientific rigour when introducing new prac-
tices. But it is not just the profession as a whole or in
the past that has been responsible for causing harm to
Preface
Albert Einstein
children. We are harming our own patients on a daily
basis if we misinterpret results of investigations or do
not obtain the most appropriate therapy for them.
Paediatricians have often thought that scientific ques-
tioning cannot be applied to children because trials or
investigations are too difficult to perform involving
them. Fortunately, this is rapidly changing, and we
hope that this book will stimulate paediatricians to
question their clinical practice and seek to discover the
latest evidence to answer their questions.
In this book there are chapters on the importance
of applied science in paediatrics, epidemiology, clini-
cal research, statistics, evidence-based medicine and
ethics, which are particularly informative as they
contain many examples of their application to paedi-
atrics. There are also chapters covering all the systems,
with a particular emphasis on embryology as this
explains the origin of many congenital abnormalities,
a brief reminder about the relevant anatomy and phys-
iology as well as a particular focus on understanding
the application and interpretation of investigations
and of the use and mechanism of action of therapies.
Rather than providing didactic details of what clinical
practice should be followed, we have tried to provide
information about the reasons and evidence base for
it, whether it be the assessment of bruises and frac-
tures in child protection, different feeding practices in
nutrition or the management of shock in intensive
care. There is also a chapter of quality improvement,
in view of its importance in providing high-quality
care.
Exam-style questions have been embedded in the
chapters. Mostly, they come before the relevant section
in the chapter, so that readers can check their know­
ledge and understanding before rather than after xi
 reading about the topic. There are also many case
histories and examples of recent advances in science
that have been of benefit in the care of children.
Further material to assist with exam preparation,
which complements this book, can be found in Clini-
cal Cases for MRCPCH Theory and Science (RCPCH). We
Preface
have assumed that readers will have read an under-
graduate textbook of paediatrics, and have tried to
avoid replicating their content.
xii
We would like to thank all those who helped bring
this ambitious project to fruition. Finally, it is to our
families we wish to extend a special thanks for putting
up with us retreating to our computers at every spare
moment for the last couple of years.
Tom Lissauer
Will Carroll

Louise Allen
MBBS MD FRCOphth
Consultant Paediatric
Ophthalmologist, Ophthalmology
Department, Cambridge
University NHS Foundation Trust,
Cambridge, UK;
Associate Lecturer, University of
Cambridge, Cambridge, UK
30. Ophthalmology
Mark Anderson
BSc BMedSci BM BS MRCPCH
Consultant Paediatrician, Great
North Children’s Hospital,
Newcastle upon Tyne Hospitals
NHS Foundation Trust, Newcastle
upon Tyne, UK
7. Accidents and poisoning
Alice J Armitage
MBBS BSc
Academic Clinical Fellow in
Paediatrics, University College
London, London, UK
8. Child protection
Megumi Baba
MBBS MRCPCH PgDip
Palliative Medicine
Specialty Registrar in Paediatric
Palliative Medicine, Paediatric
Palliative Care, The Noah’s Ark
Children’s Hospital for Wales,
Cardiff, UK
34. Palliative medicine
List of Contributors
Chris Barton
MBCHB(Hons) BSc(Hons)
Speciality Trainee in Paediatric
Oncology, Alder Hey Children’s
Hospital, UK;
Clinical Research Fellow, Institute
of Translational Research,
University of Liverpool, UK
15. Infection and immunity
Maria Bitner-Glindzicz
BSc MBBS MRCP PhD
Professor of Genetic and Genomic
Medicine, University College
London Institute of Child Health,
London, UK
31. Hearing and balance
Simon Bomken
BMedSci(Hons)
MBBS(Hons) PhD
Specialist Registrar, Department of
Paediatric and Adolescent
Haematology and Oncology, Great
North Children’s Hospital,
Newcastle upon Tyne, UK;
Honorary Clinical Lecturer,
Northern Institute of Cancer
Research, Newcastle University,
Newcastle upon Tyne, UK
37. Clinical research
Mary Brennan
MB BChir MRCPCH
Consultant Paediatric and
Adolescent Rheumatologist, Royal
Hospital for Sick Children,
Edinburgh, UK
27. Musculoskeletal disorders
Joe Brierley
MBChB FRCPCH FFICM MA
Consultant Intensivist, Paediatric
Intensive Care Unit, Great
Ormond Street Hospital, London,
UK
35. Ethics
Steve Byrne
MbChB, MRCP, PhD
Consultant Neonatologist
(retired), The James Cook
University Hospital,
Middlesbrough, UK
10. Perinatal medicine
Daniel Carroll
BM BCh BA MA DM MRCS
FRCS(Paed)
Senior Lecturer, Department of
Paediatric Surgery, James Cook
University, Townsville, QLD,
Australia
20. Genital disorders
xiii
 Will Carroll
MD MRCP MRCPCH BM BCh
BA MA(Oxon)
Consultant Paediatrician,
University Hospital of the North
Midlands, Stoke-on-Trent, UK

3. History and examination, 17.
Respiratory medicine
Peter Cartledge
BSc MBChB MRCPCH
PCME MSc
Locum Consultant Paediatrician,
General Paediatrics, Leeds
Children’s Hospital, Leeds, UK
39. Evidence-based paediatrics
Nicole Y Z Chiang
MBChB(Hons) MRCP(UK)
Specialist Trainee in Dermatology,
Department of Dermatology,
Salford Royal NHS Hospitals
Trust, Manchester, UK
25. Dermatology
Imti Choonara
MBChB MD FRCPCH
Emeritus Professor, Academic Unit
of Child Health, The Medical
School, University of Nottingham,
Nottingham, UK
36. Pharmacology and therapeutics
Timothy H Clayton
MB ChB MRCPCH FRCP(Edin)
Consultant Paediatric
Dermatologist, Dermatology
Centre, Salford Royal NHS
Foundation Trust, Manchester, UK;
Consultant Paediatric
Dermatologist, Paediatric
Dermatology, Royal Manchester
Children’s Hospital, Manchester,
UK
25. Dermatology
Aubrey Cunnington
BMBCh PhD DTM&H FRCPCH
Clinical Senior Lecturer, Section of
Paediatrics, Department of
Medicine, Imperial College
London, London, UK
15. Infection and immunity
xiv
Max Davie
MA MB BChir MRCPCH
Consultant Community
Paediatrician, Evelina London
Children’s Hospital, St Thomas’
Hospital, London, UK;
Convenor, Paediatric Mental
Health Association, London, UK
24. Child and adolescent mental
health
Graham Davies
MA FRCPCH
Consultant Paediatric
Immunologist, Great Ormond
Street Hospital, London, UK;
Honorary Senior Lecturer, Institute
of Child Health, University
College London, London, UK
15. Infection and immunity
Eleanor Dawson
MB ChB MRCPCH
Specialty Trainee in Paediatrics,
Northern Deanery, Great North
Children’s Hospital, Newcastle
upon Tyne, UK
7. Accidents and poisoning
Ellie Day
MA MBBS MRCPCH
Consultant Community
Paediatrician, Camden
Community Child Health Team,
London, UK
40. Quality improvement and the
clinician
Rachel Dommett
PhD BMBS BMedSci
Consultant Paediatrician in
Haematology/Oncology, Bristol
Royal Hospital for Children;
Honorary Lecturer, University of
Bristol, Department of Paediatric
Haematology, Oncology and Bone
Marrow Transplant, Bristol, UK
22. Oncology
Mary Fewtrell
MA MD FRCPCH
Professor of Paediatric Nutrition,
Childhood Nutrition Research
Centre, UCL Institute of Child
Health, London, UK;
Honorary Consultant
Paediatrician, Great Ormond
Street Hospital NHS Trust,
London, UK
13. Nutrition
Miriam Fine-Goulden
MA MBBS MSc MRCPCH
ST8 Paediatric Intensive Care,
Great Ormond Street Hospital for
Children, London, UK
38. Statistics
Helen Foster
MD MBBS(Hons) FRCPCH FRCP
DCH Cert Clin Ed
Professor Paediatric
Rheumatology, Newcastle
University;
Honorary Consultant in Paediatric
Rheumatology, Great North
Children’s Hospital, Newcastle
Hospitals NHS Foundation Trust,
Newcastle upon Tyne, UK
27. Musculoskeletal disorders
Shalabh Garg
MBBS MD FRCPCH
Consultant Neonatologist, The
James Cook University Hospital,
Middlesbrough UK
11. Neonatal medicine
Anu Goenka
BSc MBChB DFSRH DTM&H
MRCGP MRCPCH
MRC/ESPID Clinical Research
Training Fellow, Manchester
Collaborative Centre for
Inflammation Research, University
of Manchester, Manchester, UK
33. Global child health
Victor Grech
MD PhD(Lond) PhD(Malta)
FRCPCH MRCP(UK) DCH
Consultant Paediatrician
(Cardiology) and Associate
Professor of Paediatrics, University
of Malta;
Editor-in-Chief, Images in
Paediatric Cardiology;
Editor, Malta Medical Journal,
Malta
38. Statistics
Jessica Green
MRCPCH
Specialist Registrar in Paediatrics,
Bristol Royal Hospital for
Children, Bristol, UK
18. Cardiology
John W Gregory
MBChB DCH FRCP
FRCPCH MD
Professor in Paediatric
Endocrinology, School of
Medicine, Cardiff University,
Cardiff, UK
12. Growth and puberty,
20. Genital Disorders,
26. Diabetes and endocrinology
Hayley Griffin
MB BS BSc MRCPCH PGDip
Specialty Registrar in Paediatric
Neurodisability, Nottingham
Children’s Hospital, Nottingham,
UK
5. Developmental problems and the
child with special needs
Joanne Griffiths
MBChB
Consultant in Palliative Care and
Community Paediatrics,
Department of Child Health,
Abertawe Bro Morgannwg Health
Board, Swansea, UK
34. Palliative medicine
Richard D W Hain
MD BS MSc MSt FRCPCH
FRCPE DipPalMed PGCertEd
FHEA
Consultant and Lead Clinician,
Child Health, Children’s Hospital,
Heath Park, Wales, UK;
Visiting Professor, University of
South Wales;
Honorary Senior Lecturer, Bangor
University, Bangor, Wales
34. Palliative medicine
Christian Harkensee
MD PhD MSc DLSHTM FRCPCH
Consultant Paediatric Infectious
Diseases, Immunology and
Allergy, University Hospital of
North Tees, Stockton-on-Tees, UK
15. Infection and immunity
Deborah Hodes
BSc MB BS DRCOG FRCPCH
Consultant Paediatrician, Royal
Free London NHS Foundation
Trust and University College
London Hospitals NHS
Foundation Trust, London, UK
8. Child protection
Lee Hudson
MBChB MRCPCH FRACP
Consultant Paediatrician, General
Paediatrics and Adolescent
Medicine and Department of
Child and Adolescent Mental
Health, Great Ormond Street
Hospital for Children;
Honorary Senior Lecturer, UCL
Institute of Child Health, London,
UK
32. Adolescent medicine
David P Inwald
MB BChir FRCPCH PhD
Consultant in Paediatric Intensive
Care, Paediatric Intensive Care
Unit, St Mary’s Hospital, London,
UK
6. Paediatric emergencies and critical
care
Nadya James
MB BS BSc(Hons) MRCPCH
Consultant in Community
Paediatrics, Nottingham University
Hospitals, Nottingham, UK
4. Normal child development, 5.
Developmental problems and the
child with special needs, 28.
Neurology
Elisabeth Jameson
BSc(Hons) MBBCh(Hons) MSc
MRCPCH
Consultant Paediatrician in
Inborn Errors of Metabolism,
Willink Biochemical Genetics
Unit, St Mary’s Hospital,
Manchester, UK
29. Metabolic medicine
Sharmila Jandial
MBChB MRCPCH MD
Consultant Paediatric
Rheumatologist, Great North
Children’s Hospital, Newcastle
upon Tyne, UK
27. Musculoskeletal disorders
Huw Jenkins
MA MB BChir MD FRCP
FRCPCH
Consultant Paediatric
Gastroenterologist, Child Health,
Children’s Hospital for Wales,
Cardiff, UK
14. Gastroenterology
Christine E Jones
BMedSci BMBS MRCPCH
PGCertHBE FHEA PhD
Clinical Lecturer, Paediatric
Infectious Diseases Research
Group, Institute for Infection and
Immunity, St George’s University
of London, London, UK
15. Infection and immunity
Deirdre Kelly
FRCPCH FRCP FRCPI MD
Professor of Paediatric Hepatology,
The Liver Unit, Birmingham
Children’s Hospital;
University of Birmingham,
Birmingham, UK
21. Hepatology xv
 Peter I Lachman
MD MMed MPH MBBCH BA
FRCP FCP(SA) FRCPI
Deputy Medical Director, Great
Ormond Street Hospital NHS
Foundation Trust, London, UK

40. Quality improvement and the
clinician
Mithilesh Kumar Lal
MD MRCP FRCPCH
Consultant, Department of
Neonatal Medicine, The James
Cook University Hospital,
Middlesbrough, UK
10. Perinatal medicine, 11. Neonatal
medicine
Daniel Langer
MBChB BSc(Hons)
PGDip(Paediatric
Infectious Diseases)
Consultant Paediatrician, Epsom
and St Helier Hospital, Epsom,
UK
15. Infection and immunity
Susie Lapwood
MA(Cantab) BM BCh(Oxon)
MRCGP
Head of Research, Education and
Professional Development and
Senior Specialty Doctor, Helen
and Douglas House Hospices for
Children and Young Adults,
Oxford, UK;
Honorary Clinical Fellow, Oxford
University Hospitals NHS Trust,
Oxford, UK
34. Palliative medicine
Kirsty Le Doare
BA(Hons) MBBS MRCPCH
PGCertHBE
Consultant in Paediatric Infectious
Diseases, Department of
Paediatrics, Imperial College,
London, London, UK
15. Infection and immunity
xvi
Warren Lenney
MD DCH MBChB
Professor of Respiratory Child
Health, Keele University, Faculty
of Health, Institute for Science
and Technology in Medicine,
Keele, UK;
Consultant Respiratory
Paediatrician, Royal Stoke
University Hospital, Academic
Department of Child Health,
Stoke-on-Trent, UK
17. Respiratory medicine
Simon Li
MBChB BSc(Hons) MRCPCH
Specialist Registrar in Paediatrics,
Royal Derby Hospital, Derby, UK
3. History and examination
YiFan Liang
BM BCh MA DCH FRCPCH
Consultant in Paediatrics, South
Tees NHS Foundation Trust,
Middlesbrough, UK
34. Palliative medicine
Lynette M Linkson
MB CHB MRCP
Darzi Fellow 2013–2014, Quality
Safety and Transformation, Great
Ormond Street Hospital for
Children NHS Foundation Trust,
London, UK
40. Quality improvement and the
clinician
Rajib Lodh
MBChB BMedSci MRCPCH
PGCertMedEd PGDipClinRes
Consultant in Paediatric
Neurorehabilitation, Leeds
Children’s Hospital, Leeds
Teaching Hospitals NHS Trust,
Leeds, UK
27. Musculoskeletal disorders
Dan Magnus
BMedSci BMBS MRCPCH MSc
Consultant Paediatric Emergency
Medicine, Bristol Royal Hospital
for Children, Bristol, UK
33. Global child health
Stephen D Marks
MD MSc MRCP DCH FRCPCH
Consultant Paediatric
Nephrologist, Department of
Paediatric Nephrology, Great
Ormond Street Hospital for
Children NHS Foundation Trust,
London, UK
19. Nephrology
Michael Marsh
MBBS FRCP
Medical Director, University
Hospital Southampton and
Consultant Paediatric Intensivist,
University Hospital Southampton,
Southampton, UK
6. Paediatric emergencies and critical
care
Katherine Martin
MBChB BSc(Hons) MRCPCH
Consultant Paediatrician, Child
Development Centre, Nottingham
Children’s Hospital, Nottingham
University Hospitals NHS Trust,
Nottingham, UK
5. Developmental problems and the
child with special needs
Gary McCullagh
MB BCH BAO MRCPCH
Consultant Paediatric Neurologist,
Royal Manchester Children’s
Hospital, Manchester, UK
28. Neurology
Janet McDonagh
MB BS MD
Senior Lecturer in Paediatric and
Adolescent Rheumatology, Centre
for Musculoskeletal Research,
University of Manchester,
Manchester, UK
32. Adolescent medicine
Flora McErlane
MBChB MRCPCH MSc
Consultant Paediatric
Rheumatologist, Paediatric
Rheumatology, Great North
Children’s Hospital, Newcastle
upon Tyne, UK
27. Musculoskeletal disorders
Anil Mehta
MBBS MSc FRCPCH FRCP
Hon Consultant/Reader, CVS
Diabetes, University of Dundee,
Dundee, UK
1. The role of science and research in
paediatrics
Nazakat Merchant
MBBS FRCPCH MD
Consultant Neonatologist, West
Hertfordshire NHS Trust, Watford
Hospital, Watford, UK
10. Perinatal medicine,
11. Neonatal medicine
Lawrence Miall
MB BS BSc MMedSc FRCPCH
Consultant Neonatologist, Leeds
Teaching Hospital, Leeds, UK;
Hon Senior Lecturer, University of
Leeds, Leeds, UK
10. Perinatal medicine
Mike Miller
MRCPCH MRCP MB BS Dip
Pall Med
Consultant, Martin House
Children’s Hospice, Wetherby, UK
34. Palliative medicine
Neena Modi
MB ChB MD FRCP FRCPCH
FRCPE
President of the Royal College of
Paediatrics and Child Health,
London, UK;
Professor of Neonatal Medicine,
Imperial College London, London,
UK
1. The role of science and research in
paediatrics
Daniel Morgenstern
MB BChir PhD FRPCH
Consultant Paediatric Oncologist,
Great Ormond Street Hospital,
London, UK;
Honorary Senior Lecturer, UCL
Institute of Child Health, London,
UK
22. Oncology
Omendra Narayan
MBBS MSc FRCPCH
Consultant in Paediatric
Respiratory Medicine, Royal
Manchester Children’s Hospital,
Manchester, UK
15. Infection and immunity
David O’Connor
MBChB PhD FRCPath
Locum Consultant in Paediatric
Haematology, Department of
Haematology, Great Ormond
Street Hospital, London, UK
23. Haematology
Ian Petransky
MBBS MRCPCH
Paediatric Registrar, Department of
Paediatrics, Chesterfield Royal
Hospital, Chesterfield, UK
3. History and examination
Bob Phillips
BMBCh MA MMedSci PhD
NIHR Post-Doctoral Fellow and
Honorary Consultant in Paediatric
Oncology, Centre for Reviews and
Dissemination, University of York,
York, UK
39. Evidence-based paediatrics
Kaukab Rajput
FRCS FRCP MSc
Consultant Audiovestibular
Physician, Great Ormond Street
Hospital for Sick Children NHS
Foundation Trust, London, UK
31. Hearing and balance
Dipak Ram
MBBS MRCPCH
Paediatric Neurology Specialist
Registrar, Royal Manchester
Children’s Hospital, Manchester, UK
28. Neurology
Sarah Rayfield
MB BS MSc MFPH
Specialist Registrar Public Health,
Oxford Deanery, Oxford, UK
2. Epidemiology and public health
Irene A G Roberts
MD FRCPath
Professor of Paediatric
Haematology, Oxford University
Department of Paediatrics,
Children’s Hospital and Molecular
Haematology Unit, Weatherall
Institute of Molecular Medicine,
John Radcliffe Hospital, Oxford,
UK
23. Haematology
Kerry Robinson
MA MRCPCH
Consultant Paediatrician,
Whittington Health NHS Trust,
London, UK
8. Child protection
Jane Runnacles
MBBS BSc(Hons) MRCPCH MA
Consultant Paediatrician, Royal
Free Hospital, London, UK
40. Quality improvement and the
clinician
Nicola Ruth
MBChB BSc(Hons) PGA(Med
Education) MRCPCH
Clinical Research Fellow in
Paediatric Hepatology, The Liver
Unit, Birmingham Children’s
Hospital/University of
Birmingham, Birmingham, UK
21. Hepatology
Manish Sadarangani
BM BCh MRCPCH DPhil
Clinical Lecturer and Honorary
Consultant in Paediatric Infectious
Diseases & Immunology,
University of Oxford, Oxford, UK
15. Infection and immunity
Helen Sammons
MBChB MRCPCH DM
Associate Professor of Child
Health at the University of
Nottingham and Consultant
Paediatrician at the Derbyshire
Children’s Hospital, Derby, UK
36. Pharmacology and therapeutics
xvii
 Nwanneka N Sargant
BM MCPCH DFRSH
Paediatric Specialty Registrar,
University Hospitals Bristol NHS
Trust, Bristol Royal Hospital for
Children, Bristol, UK

32. Adolescent medicine
Richard H Scott
MA MBBS MRCPCH PhD
Consultant in Clinical Genetics,
Department of Clinical Genetics,
North East Thames Regional
Genetics Service, Great Ormond
Street Hospital, London, UK;
Honorary Senior Lecturer,
Genetics and Genomic Medicine
Unit, Institute of Child Health,
London, UK
9. Genetics
Mike Sharland
MD MRCP FRCPCH
Professor of Paediatric Infectious
Diseases, Paediatric Infectious
Diseases Research Group, Institute
for Infection and Immunity, St
George’s University of London,
London, UK
15. Infection and immunity
Rajiv Sinha
MD FRCPCH(UK) CCT(UK)
Associate Professor, Paediatric
(Nephrology), Institute of Child
Health, Kolkata, India;
Consultant Paediatric
Nephrologist, Fortis Hospital,
Kolkata, India
19. Nephrology
Sunil K Sinha
MD PhD FRCP FRCPCH
Professor of Paediatrics and
Neonatal Medicine, The James
Cook University Hospital,
University of Durham,
Middlesbrough, UK
10. Perinatal medicine, 11. Neonatal
medicine
xviii
Lynn Sinitsky
BA MBBS MRCPCH MSc
Paediatric Registrar, London
Deanery, London, UK
6. Paediatric emergencies and critical
care
Charlotte Slaney
BMBCH BA MA BMBCh
MRCPCH FRCR FRANZCR
Staff Specialist in Radiology,
Queensland X-Ray, Townsville,
Queensland, Australia
20. Genital disorders
Elizabeth Starkey
MRCPCH MBChB
Locum Consultant Paediatrician,
Royal Derby Hospital, Derby, UK
36. Pharmacology and therapeutics
Jacqui Stedmon
BSc PhD BPS DipClinPsy
Associate Professor/Programme
Director, Doctorate Programme in
Clinical Psychology, University of
Plymouth, Plymouth, UK
24. Child and adolescent mental
health
Shereen Tadros
BMedSci BMBS MML MRCPCH
Specialist Trainee in Clinical
Genetics, Department of Clinical
Genetics, North East Thames
Regional Genetics Service, Great
Ormond Street Hospital for
Children, London, UK
9. Genetics
Hannah Tobin
BA BM BCh MRCPCH
Trainee in General Paediatrics,
Barnet General Hospital, Royal
Free NHS Trust, London, UK
13. Nutrition
Robert M R Tulloh
BM BCh MA DM(Oxon) Cert Ed
FRCP FRCPCH
Professor, Congenital Cardiology,
University of Bristol, Bristol, UK;
Consultant Paediatric Cardiologist,
Bristol Royal Hospital for
Children, Bristol, UK
18. Cardiology
Paul J Turner
BM BCh FRACP PhD
MRC Clinician Scientist in
Paediatric Allergy & Immunology,
Imperial College London, London,
UK;
Hon Consultant in Paediatric
Allergy & Immunology, Imperial
College Healthcare NHS Trust,
London, UK
16. Allergy
Josef Vormoor
Dr med
Sir James Spence Professor of
Child Health and Director of the
Northern Institute for Cancer
Research, Northern Institute for
Cancer Research, Newcastle
University, Newcastle upon Tyne,
UK;
Honorary Consultant Paediatric
Oncologist, Great North
Children’s Hospital, Newcastle
upon Tyne Hospitals NHS
Foundation Trust, Newcastle upon
Tyne, UK
37. Clinical research
John O Warner
OBE MD FRCP FRCPCH
FMedSci
Professor of Paediatrics, Imperial
College London, London, UK;
Honorary Professor, Paediatrics
and Child Health, University of
Cape Town, Cape Town, South
Africa
16. Allergy
Another random document with
no related content on Scribd:
Stockdale, Gnr. J.
Stott, Gnr. F.
Tallent, Gnr. W.
Thornburrow, Dvr. J.
Tonkin, Gnr. J.
Turner, Dvr. J.
Tyson, Dvr. S.
Waddington, Dvr. E.
Waldwin, Gnr. W.
Wilson, Dvr. P.
Woodruffe, Dvr. F. E.
Wolsey, Dvr. S.

211th Brigade, R.F.A. (T.)

Other Ranks

Ashworth, Fitter-Cpl. R.
Ashworth, Gnr. S.
Bardsley, Gnr. H.
Baybutt, Cpl. A.
Bewley, Dvr. J.
Blenkin, Cpl. T. J.
Boardman, Gnr. T. H.
Bridge, Gnr. A.
Bush, Gnr. P.
Bushby, Gnr. E.
Chipchase, Gnr. J.
Clayton, Sgt. E.
Connor, Gnr. J. W.
Cook, Sgt. T.
Cook, Dvr. W.
Crickett, Gnr. J.
Cunnane, Gnr. T.
Curtis, Bdr. W.
Dixon, Gnr. R.
Dixon, Dvr. W.
Earnshaw, Dvr.
Edwards, Dvr. A.
Edwards, Gnr. R.
Fell, Bdr. J.
Ford, Gnr. A.
Fox, Sgt. W.
Gambles, Bdr. J.
Gray, Farr.-Sgt. W.
Hallworth, Cpl. T.
Hancock, Siglr. G. A.
Hardman, Gnr. E. C.
Hardy, Gnr. H.
Hart, Sgt. T. V.
Heaney, Dvr. W.
Henshall, Gnr. D.
Holliday, Gnr. R.
Holmes, Bdr. W.
Hope, Bdr. L.
Howarth, Dvr. C. J.
Hunter, Gnr. N.
Jeffrey, Dvr. H.
Johnstone, Gnr. H.
Kent, Dvr. S.
Lawson, Bdr. T.
McEvoy, Gnr. R.
McGee, Gnr. A.
Murray, Dvr. F.
Oliver, Dvr. A. E.
O’Neill, Dvr.
Reed, Gnr. M.
Rowbotham, Dvr. S.
Russell, Dvr. N.
Schofield, Gnr. J.
Sharpe, L.-Cpl. J. H.
Shaw, Cpl. T.
Shortland, Dvr. E.
Smith, Sgt. W.
Taft, Gnr. S.
Thompson, Sgt. J.
Threlfall, Gnr. L. H.
Varty, Gnr. T. B.
Waddington, Bdr. R.
Wagstaff, Gnr. S.
Warburton, Bdr. R.
Webster, Gnr. H. L.
Whiteley, Gnr. R.
Whitworth, Gnr. C.
Wilson, Cpl. J. G.
Wood, Gnr. W. H.

42nd DIVISIONAL AMMUNITION COLUMN

Other Ranks

Benson, Dvr. H.
Duerden, Cpl. E.
Harding, Dvr. A.
Holt, Dvr. L.
Pontefract, Dvr. V.
Prattley, Dvr. G. T.
Rolley, Dvr. J.
Whaite, Dvr. A.
Wilson, S/S. J.

ROYAL ENGINEERS

427 Field Coy., R.E.

Officers

Eastwood, Lieut. R. A.
Mackenzie, Lieut. L. A.
Taunton, Lieut. O., M.C.
Ainley, 2nd Lieut. K. E. D.
Hunter, 2nd Lieut. J. K.
Malcolm, 2nd Lieut. W. N.

Other Ranks

Abrahams, 2nd Cpl. E.

Bailey, Sap. E.
Bancroft, Sap. A.
Barlow, Sap. E.
Bettley, Sap. J. H.
Bird, Drv. C.
Birkenshaw, Sap. F.
Bishop, Sap. T.
Bowker, Sap. A.
Bowker, Drv. T.
Broady, Sap. G. H.
Burke, Sap. F.
Burton, Sap. L.
Catterall, Sap. J.
Cawley, Sap. H.
Coglan, Sap. T.
Conway, Sap. T.
Dixon, Sap. R.
Dwyer, Sap. A.
Eastwood, Sap. H.
Farnworth, Sap. J.
Francis, Sap. F.
Garstang, Sgt. J. E.
Giles, Sap. W. D.
Gloyne, Sap. P.
Greenhalgh, Sap. E. A.
Halliwell, Sap. G. N.
Henderson, L.-Cpl. J. F.
Hopkins, Sap. H. B. J.
Horne, 2nd Cpl. W.
Hulme, Sap. J.
Hurring, Sap. W.
Jennings, Sap. A.
Later, Sgt. J. O.
Lee, Sap. H. A.
Lees, Drv. F. B.
Leppard, Sap. P.
Loxley, Sap. E.
Maher, Sap. R.
Melville, Sap. H.
Moss, Sgt. H.
Mottram, Sap. W.
Nolan, Sgt. J. W.
Owen, Sap. H.
Penny, Sap. A.
Perkins, L.-Cpl. F.
Probyn, Sap. H.
Ritchie, Sap. C.
Smith, L.-Cpl. E.
Smith, Sap. H.
Smith, Drv. J.
Sproson, Cpl. G.
Tolson, 2nd Cpl. H.
Wilkinson, Sap. W.
Wright, Drv. W.

428 Field Coy., R.E.

Officers

Carver, Capt. O. A.
Bull, Lieut. G. J. O.
Angus, 2nd Lieut. R. B.
Saint, 2nd Lieut. J. H.
Woods, 2nd Lieut. B. H.

Other Ranks

Atkinson, Sap. M.
Barlow, Sap. W.
Bold, Drv. C. H.
Bradshaw, Sap. A.
Brooks, Trmptr. W.
Brocklesby, L.-Cpl. E.
Butterworth, L.-Cpl. J.
Cooper, Sap. A.
Dunn, Sap. J.
Elliott, Sap. C. K.
Farmer, Drv. H.
Goldstraw, 2nd Cpl. R.
Gore, Sap. A.
Greenhalgh, Sap. H.
Greenwood, Sap. W.
Grimshaw, Sap. G. H.
Hampson, Sap. G.
Harwood, Sap. J.
Hinsley, Sap. T
Hodge, Sap. W. R.
Jackson, Sap. H.
Kelsall, Sap. J. H.
Kerridge, Cpl. W.
Knott, Sap. W.
Magee, Drv. J.
McLeavy, Cpl. G.
McLeod, Sap. W.
McQuinn, L.-Cpl. O.
Mellor, Sgt. W.
Moor, Sap. H.
Moscrop, Sap. J. A.
Mountfield, Sap. H.
Naylor, Cpl. W.
Nugent, Sap. J.
O’Donnell, Sap. F.
Palmer, Sap. J. E.
Pickston, L.-Cpl. H. V.
Potts, Sap. J.
Robinson, Sap. G.
Saunders, Sap. J.
Scott, Sap. J.
Shaw, Cpl. H.
Shaw, L.-Cpl. T. E.
Staresmere, Sap. W.
Stephenson, Sap. F.
Swift, L.-Cpl. H.
Taylor, Drv. J.
Warburton, Sap. H.
Ward, Sap. T. H.
Waterhouse, Sap. T.
Wielding, 2nd Cpl. T.

429 Field Coy., R.E.

Officers

Chapman, Lieut. D. C.

Other Ranks

Ashton, Sap. A.
Baker, Sap. W. F.
Barraclough, Sap. F.
Bates, Sap. S.
Carter, Sap. J. W.
Cooke, Sap. F.
Deedman, Sap. S. F.
Evan, Sap. J. T.
Flynn, Sap. J.
Galpine, Sap. H.
Hellon, Sap. J. W.
Holland, Sap. J.
Hynes, Cpl. W.
Jones, Drv. B.
Kershaw, Sap. G. B.
Mansfield, Sap. A.
McCannah, Sap. S.
Meckin, L.-Cpl. J.
Mort, Cpl. S. C.
Newton, Sgt. J. L.
Rooney, Sap. J.
Royles, Sap. J. H.
Scott, Sap. W.
Shaw, Sap. T. J.
Staveley, Sap. H.
Tomlinson, Sap. J.
Thompson, Sap. J. C.
Walker, Drv. A. W.
Walker, L.-Cpl. G. H.
Watson, Sap. H. H.
Williams, Sap. C.
Williams, Sap. R. C.
Wilkinson, Sap. W.
Wright, L.-Cpl. D.
Yates, Sap. S.

42nd Division Signal Coy., R.E.

Officers

Williamson, Capt. C. H., M.C.

Moore, Lieut. H. T. P., M.C.

Other Ranks

Aitchison, Sap. E.
Ardis, Cpl. J.
Bayley, Drv. T.
Broderick, Sap. J., D.C.M.
Couch, L.-Cpl. H., M.M.
Cox, L.-Cpl. R. S.
Dowd, Sap. H. W.
Edwards, S.S. T.
Fielding, Cpl. J., M.M.
Findlay, Pioneer R.
Garside, Sap. F.
Hall, Pioneer E.
Hartley, Drv. W.
Heap, Sap. C.
Heywood, Sap. A.
Higginbottom, Sap. G.
Humphreys, Sap. C. Y.
Jackson, Sap. F.
Kennedy, Cpl. J.
Latter, Sap. S.
Law, Pioneer J. W.
Ling, Sap. A.
Lorimer, Sap. W. E.
Lowe, Drv. J.
McGuire, Drv. J.
Naylor, Sap. E. C.
Penson, Sap. C. W.
Poole, Sap. A.
Richardson, Pioneer J.
Sheppard, Sap. F. W.
Sinclair, Sap. J.
Smith, Sap. J. W.
Sutcliffe, Pioneer N.
Walsh, Sap. J.

125th INFANTRY BRIGADE

1/5 BATTALION LANCASHIRE FUSILIERS
 Officers

Clive, Lt.-Col. P. A., D.S.O.

Holberton, Lt.-Col. P. V.
Bentley, Capt. F. M., M.C.
Bridge, Capt. J. K.
Briggs, Lieut. W. L.
Hudson, Capt. A. P.
Jemkins, Capt. E. E., M.C.
Kay, Capt. G. C.
Milnes, Capt. S. H.
Paton, Capt. M. B.
Cameron, Lieut. W. G.
Frizelle, Lieut. E. S.
Fryer, Lieut. W. B.
Grant, Lieut. R. W. G.
Harrison, Lieut. C. H.
Hawksey, Lieut. B. R.
Hinckley, Lieut. A.
Hoyle, Lieut. H. K.
Mashiter, Lieut. T. A. G.
Morgan, Lieut. V. H.
Murphy, Lieut. G.
Page, Lieut. J. K. S.
Renshaw, Lieut. A.
Stafford, Lieut. A. D.
Stott, Lieut. W. E.
Tankard, Lieut. W.
Templeman, Lieut. J. W.
Thompson, Lieut. M. B.
Tristram, Lieut. E. B.
Whittam, Lieut. F.
Yapp, Lieut. W. C.

Other Ranks

Adams, Pte. H.
Alderson, Pte. R. A.
Aldridge, Pte. G.
Allcock, Pte. W.
Allen, Pte. H.
Allen, Pte. W.
Alliban, Pte. H.
Alston, L.-Cpl. H.
Andrews, L.-Cpl. H. H.
Andrews, Pte. J.
Andrews, Pte. R. A.
Ansins, Pte. G.
Antrobus, Pte. W.
Archer, Pte. E. J.
Armstrong, L.-Cpl. W.
Ash, Pte. G. V.
Ashton, Pte. A.
Ashton, Pte. J. H.
Ashton, Pte. R. J.
Ashworth, Pte. H.
Atkinson, Pte. W.
Austin, Pte. J.
Austin, Pte. R.
Bageant, Pte. F.
Bamford, Pte. B. P.
Bamford, Pte. W.
Bamford, Pte. W.
Banks, C.Sgt.-Mjr. W.
Barker, Pte. L.
Barker, Pte. T.
Barker, Cpl. T. H.
Barley, Pte. G.
Barlow, Pte. F.
Barnes, L.-Cpl. C. E.
Barton, Cpl. J. A.
Beardsworth, Pte. R.
Beaumont, Pte. J.
Bedford, Pte. C.
Bedford, Pte. C. J.
Bennett, Pte. J.
Bennett, Sgt. J.
Bent, Pte. W.
Berry, Pte. H.
Berry, Pte. J.
Berry, Pte. L.
Bills, Pte. H.
Birch, Pte. H.
Birchall, Pte. F.
Bird, Pte. W. T.
Bishop, Pte. C.
Boardman, Pte. C.
Boardman, Pte. D.
Boon, L.-Cpl. J. J.
Booth, Pte. N.
Booth, Sgt. H.
Booth, Pte. J. W.
Booth, Pte. S.
Boothman, Pte. J.
Bowden, Cpl. C.
Bowker, Cpl. T.
Bradburn, Pte. H.
Bradford, Pte. L.
Bradley, Pte. H.
Bradshaw, Pte. A.
Brand, Sgt. H.
Brennan, Cpl. J.
Brierley, Pte. J. J.
Brocklehurst, Pte. F.
Brooks, Pte. A.
Brooks, Cpl. W.
Brown, Pte. T.
Brown, Pte. G.
Brown, Pte. H.
Buckley, Cpl. E. F.
Buckley, Pte. J.
Bunn, Pte. A.
Bunn, L.-Cpl. J. J.
Burden, Pte. F.
Burke, Pte. J.
Burke, Cpl. P.
Burrows, Pte. C.
Burston, Pte. W.
Butterworth, Pte. A.
Butterworth, Pte. E.
Butterworth, Pte. F.
Butterworth, Pte. G.
Butterworth, Cpl. J.
Butterworth, Pte. J.
Butterworth, Pte. R.
Butterworth, Pte. W.
Butterworth, Cpl. W.
Buxton, Pte. G. V.
Calderbank, Pte. F.
Calverley, L.-Cpl. J. E.
Carless, C.Sgt.-Mjr. W., D.C.M.
Carmichael, Pte. R. F.
Carney, Pte. J.
Carr, Pte. J.
Carroll, Pte. W.
Carruthers, Pte. J. R.
Chadwick, C.Sgt.-Mjr. J.
Chamley, Pte. W.
Chapman, Pte. E.
Charles, Pte. D.
Charman, Pte. A.
Clarke, Pte. G.
Clarke, Pte. W.
Clarke, Cpl. S. E.
Clifford, Pte. M.
Cockcroft, L.-Cpl. E.
Coe, Pte. A.
Collantine, Pte. J.
Collinson, Pte. F.
Compston, Cpl. T. H.
Connell, Pte. W.
Connelly, Pte. J.
Consterdine, Sgt. W.
Cookson, Pte. H.
Cooper, Pte. A.
Cooper, Pte. W. E.
Corlett, Pte. J. A.
Corser, Cpl. F.
Cowley, Pte. J.
Crabtree, Pte. J.
Crabtree, Pte. W.
Crawford, Pte. H.
Crawford, Pte. W.
Crawford, Pte. W.
Crook, Pte. A.
Crossley, Pte. J. H.
Crowther, Pte. W.
Cryer, Pte. F.
Cullen, Pte. J.
Curran, Pte. J.
Curran, Pte. T.
Cutts, Pte. H.
Dakin, Pte. E. B.
Davison, Pte. T.
Dawson, L.-Cpl. W. L.
Dean, Pte. R.
Dearden, Sgt. F.
Dickie, L.-Cpl. D.
Dixon, Pte. C.
Dixon, Pte. F.
Dobson, Pte. T.
Dodd, Pte. T.
Douglas, Pte. J. W.
Duckworth, Pte. R.
Dudley, Pte. H.
Duncan, Pte. W.
Duxbury, Pte. W.
Eatough, Pte. L.
Eccles, Pte. T.
Eckersley, Sgt. E.
Eckersley, Pte. F.
Egerton, Pte. F.
Entwistle, Pte. D.
Evans, Pte. C.
Evans, L.-Cpl. E. R.
Fitzsimmonds, Pte. T.
Fletcher, Pte. G.
Flook, Pte. A.
Ford, Pte. J.
Foxcroft, Pte. A.
Foxcroft, Pte. W.
Fraser, Pte. J.
French, Pte. G.
Frith, Pte. C.
Garland, Pte. A.
Garner, Pte. G. H.
Garner, Pte. W. R.
Garswood, Pte. G.
Gibbons, Pte. C.
Glasgow, Pte. R.