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One-pot Amphetamine Synthesis From P2NP With NaBH4_CuCl2 (1kg scale) _ Breaking Bad
One-pot Amphetamine Synthesis From P2NP With NaBH4_CuCl2 (1kg scale) _ Breaking Bad
Reaction scheme:
Reagents:
Isopropyl alcohol (IPA) 20 L;
Distilled water 6.2 L;
Sodium borohydride (NaBH4) 1739 g;
P2NP (Phenyl-2-propanone) 1000 g;
Copper (II) chloride (CuCl2) 105 g;
Sodium hydroxide (NaOH) water solution 25% 8 L;
Dry acetone 2.5 L;
Sulfuric acid (or orthophosphoric acid);
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7/15/24, 3:14 PM One-pot Amphetamine Synthesis From P2NP With NaBH4/CuCl2 (1kg scale) | Breaking Bad
Amphetamine synthesis
Novator Apr 4, 2023 53 amphetamine amphetamine synthesis nabh4 p2np
p2np synthesis phenyl-2-nitropropene video synthesis
Amphetamine synthesis via NaBH4 reductive amination from P2NP...
Synthesis:
1. A mixture of IPA and H2O 2:1 (18 liters) is added to a 50 L batch reactor.
2. Solid NaBH4 (1739 g) is added in one portion and stirrer is turned on.
3. Pure P2NP (1000 g) is added in several small portions to keep the mixture temperature
below 60 °С.
P2NP (Phenyl-2-propanone)
4. A solution of CuCl2 (105 g) in water (200 ml) is slowly added dropwise to keep the
mixture temperature below 80 °С.
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7/15/24, 3:14 PM One-pot Amphetamine Synthesis From P2NP With NaBH4/CuCl2 (1kg scale) | Breaking Bad
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7/15/24, 3:14 PM One-pot Amphetamine Synthesis From P2NP With NaBH4/CuCl2 (1kg scale) | Breaking Bad
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