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Chapter 3 - Biomacromolecules
Chapter 3 - Biomacromolecules
3
The Molecules of Life
Double bond
Carbon skeletons vary in length Carbon skeletons may
have double bonds,
which can vary in location
Dehydration
H2O
reaction
Longer polymer
(a) Building a polymer chain
Figure 3.4-1
Hydrolysis
OH H
Figure 3.4-2
• Hydrolysis
• breaks bonds between monomers,
• adds a molecule of water, and
• reverses the dehydration reaction.
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Polymers
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Figure 3.5-1
Mono-
saccharides
Glucose Fructose
C6H12O6 C6H12O6
Isomers
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(same formula, different arrangements)
Figure 3.6
OH H
Glucose Galactose
H2O
Lactose
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Figure 3.9
Starch granules
in potato tuber cells
(a) Starch
Glucose
Glycogen granules monomer
in muscle
tissue
(b) Glycogen
Cellulose microfibrils
(c) Cellulose
in a plant cell wall
Cellulose
molecules
Hydrogen bonds
• Monosaccharides
• are the monomers of carbohydrates and
• cannot be broken down into smaller sugars.
• Disaccharides include
• lactose in milk, made from the monosaccharides
glucose and galactose,
• maltose in beer, malted milk shakes, and malted
milk ball candy, and
• sucrose in table sugar.
• Polysaccharides
• are complex carbohydrates and
• are made of long chains of sugars—polymers of
monosaccharides.
• Starch
• is a familiar example of a polysaccharide,
• consists of long strings of glucose monomers, and
• is used by plant cells to store energy.
• Glycogen
• is used by animal cells to store energy and
• is broken down to release glucose when you need
energy.
• Cellulose
• is the most abundant organic compound on Earth,
• forms cable-like fibrils in the walls that enclose plant
cells, and
• cannot be broken by any enzyme produced by
animals.
H HO
Fatty acid
H2O
Glycerol
(a) A dehydration reaction linking a fatty acid to glycerol
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Figure 3.11-2
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Phospholipids
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Steroids
TYPES OF FATS
Saturated Fats Unsaturated Fats
Margarine
• Hydrogenation
• adds hydrogen,
• converts unsaturated fats to saturated fats,
• makes liquid fats solid at room temperature, and
• creates trans fats, a type of unsaturated fat that is
particularly bad for your health.
• Cholesterol is
• a key component of cell membranes and
• the “base steroid” from which your body produces
other steroids, such as estrogen and testosterone.
• Proteins
• are polymers of amino acid monomers,
• account for more than 50% of the dry weight of most
cells, and
• are instrumental in almost everything cells do.
DNA
Nucleic
acids
RNA
Amino acid
Protein
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Figure 3.16-1
Amino Carboxyl
group group
Side
chain
Hydrophobic Hydrophilic
side chain side chain
Leucine Serine
(b) Examples of amino acids with hydrophobic and hydrophilic
side chains
OH H
Side Side
chain chain
Amino acid Amino acid
OH H
Side Side
chain chain
Amino acid Amino acid
Dehydration reaction
H2O
Side Side
chain chain
Peptide bond
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Figure 3.4-3
DOI: 10.1126/science.abb3405
Myoglobin: An example of a tertiary structure
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ALPHA HELIX
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Tertiary Structure
• The various alpha helices
and beta pleated sheets
interact to form a globular
structure.
• This globular structure is
unique for each
polypeptide.
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Quaternary Structure
• Some proteins contain
more than one
polypeptide chain.
• Each of these
polypeptides has its own
unique tertiary structure.
– These polypeptides
interact to form a more
complex globular
structure.
• Quaternary structure can
be stabilized by disulfide
bonds.
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Myoglobin: An example of a tertiary structure
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Hemoglobin: An example of a quaternary structure
129
The amino acid sequence of lysozyme
SEM
Amino acid sequence Normal peptide Normal red
blood cell
(a) Normal hemoglobin
SEM
Amino acid sequence Sickle-cell Sickled red
polypeptide blood cell
(b) Sickle-cell hemoglobin
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Form and Function
Normal
protein
Prion
Clusters
of prions
Skull
Prion Prion
converts proteins
Brain normal clump
proteins together
• How is it possible to make the huge variety of proteins found in your body from just 20
kinds of amino acids?
• Like the English alphabet used to make different words by varying the sequence of
just 26 letters, proteins use 20 different “letters” (amino acids) to create
polypeptides hundreds or thousands of amino acids in length.
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Nucleic Acids
Nitrogenous base
(can be A, G, C, or T)
Connection
to the next
nucleotide
in the chain
Thymine (T)
Phosphate
group Phosphate
Base
Sugar
Connection to the (deoxyribose)
next nucleotide in Sugar
the chain
(a) Atomic structure (b) Symbol used in this book
DNA RNA
Components of Nucleotides
Nitrogenous
base * *
T
A DNA
G
RNA
Nitrogen attaches
* with sugar molecule
C U
Sugar-phosphate
backbone
Base
Nucleotide pair
Hydrogen
bond
Bases
Adenine (A)
Guanine (G)
Thymine (T)
• Dehydration reactions
• link nucleotide monomers into long chains called
polynucleotides,
• form covalent bonds between the sugar of one
nucleotide and the phosphate of the next, and
• form a sugar-phosphate backbone.
Sugar-phosphate
backbone
Base
Nucleotide pair
Hydrogen
bond
Bases
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Nucleic Acids
Carbohydrates
Monosaccharides:
glucose, fructose;
Dietary energy; disaccharides:
storage; plant lactose, sucrose;
structure polysaccharides:
starch, cellulose
Monosaccharide
Lipids
Long-term
Fatty acid
Fats (triglycerides);
energy storage
steroids
(fats);
Glycerol (testosterone,
hormones
Components of estrogen)
(steroids)
a triglyceride
Proteins
Amino Carboxyl
group group
Lactase
Enzymes, structure,
(an enzyme);
storage, contraction,
hemoglobin
transport, etc. Side (a transport protein)
chain
Amino acid
Nucleic acids
Phosphate
Base
Information
storage DNA, RNA
Sugar
Nucleotide
Monosaccharides:
glucose, fructose;
Dietary energy;
disaccharides:
Carbohydrates storage; plant
lactose, sucrose;
structure
polysaccharides:
starch, cellulose
Monosaccharide
Long-term
Fats (triglycerides);
energy storage Fatty acid
steroids
Lipids (fats);
Glycerol (testosterone,
hormones
Components of estrogen)
(steroids)
a triglyceride
Amino Carboxyl
group group
Lactase
Enzymes, structure,
(an enzyme);
Proteins storage, contraction,
hemoglobin
transport, etc. Side (a transport protein)
chain
Amino acid
Phosphate
Base
Information
Nucleic acids storage DNA, RNA
Sugar
Nucleotide
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Figure 3.0-2
©
2016
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Biology and Society: Got
Lactose?
• Lactose intolerance can be addressed by
– avoiding lactose-containing foods or
– consuming lactase pills along with food.
©
2016
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The Process of Science: Does Lactose
Intolerance Have a Genetic Basis?
• Observation: Most lactose-intolerant people have
a normal version of the lactase gene.
• Question: What is the genetic basis for lactose
intolerance?
• Hypothesis: Lactose intolerance can be correlated
with a single nucleotide at a particular site within
one chromosome.