ELITE INTERNATIONAL COLLEGE OF HEALTH 11.

Idiosyncracy is attributable to;

SCIENCE AND TECHNOLOGY ZARIA A. Immunological basis
100 LEVEL SECOND SEMESTER EXAMINATION B. Genetic abnormality
C. Over dose of a drug
SESSION: 2023/2024
12. Biotransformation facilitates the excretion of
COURSE: ACTION AND USES OF COMMON drugs by changing them into;
MEDICINE A. More ionized and less lipid soluble
DEPARTMENT PHARMACY MARKS 60 B. Less ionized and more lipid soluble
TIME: 2HRS C. More ionized and more lipid soluble
Type b
13. When a drug potentiates or complements the
1. Pharmacodynamics is the study of; action of other drug the phenomenon is called;
A. Preparation of drug A. Antagonism
B. Biochemical and physiological effects of drug B. Drug interaction
C. Toxic effect of drugs C. Synergism
14. Most drugs and metabolites are excreted by;
2. Bioavailability means the; A. The kidneys
A. Rate of absorption of drugs B. The bile
B. Rate and extent of absorption of drugs C. The lungs
C. Rate of excretion of the drugs 15. Pharmacodynamics considers;
A. The way in which the drug affects the body
3. Agonist has got; B. The effect of drug in the body and mode of action
A. Affinity for the receptor C. Drug metabolism
B. Efficacy 16. A drug allergy occurs;
C. Affinity as well as efficacy A. When too much drug has accumulated in the body
4. If one drug antagonizes the action of other drug B. When body sees the drug as an antigen and an
by interacting with different receptor, the immune response is established against the drug
antagonism may be called as; C. An unwanted but predictable response to a drug
A. Chemical antagonism 17. The drug receptor interaction is usually;
B. Physiological antagonism A. Irreversible
C. Pharmacological antagonism B. Reversible
5. Antagonism may be called as competitive if; C. Always irreversible
A. Both drugs have different receptors
B. Both drugs has affinity for the same receptors 18. Pharmacognosy deals with;
C. Both drugs interact chemically A. Preparation of drug
B. Properties and identification of drugs
6. Digoxin is obtained from; C. Doses of drugs
A. Plant source
B. Mineral source 19. A drug that binds to cell receptor and cause a
C. Plant and synthetics response is called as;
7. Pharmacokinetics is the study of; A. Agonist
A. What is drug doing to the body B. Antagonist
B. What is body doing with the drug C. Receptor blocker
C. What is drug doing with other drugs 20. Drugs are excreted from the body through-
8. Elimination of drug means; (a) Kidney
A. Excretion of drug (b) Breast milk, saliva, sweat & bile.
B. Metabolism of drugs (c) Intestine
C. Metabolism and excretion of drugs
(d) All of the above.
9. Protein bound drugs are;
21. the human body is known as-
A. Pharmacologically inactive
B. Pharmacologically more active (a) Pharmacokinetics
C. Pharmacologically less active (b) Toxicology
(c) Pharmacology
10. Posology deals with; (d) Pharmacodynamics
A. Weighing and measuring of drug 22. Penicillin can be gotten from both natural and
B. Dose and dosage semisynthetic sources? True or false
C. Metabolism of drugs
23. The rate of absorption of a drug is affected by
(a) Route of drug administration
 (b) Solubility of the drug
(c) Site of administration
(d) All of the above
24. What does “pharmacokinetics” include?
a) Localization of drug action
b) Mechanisms of drug action
c) Excretion of substances
d) Interaction of substances
25. Pharmacokinetics is:
a) The study of biological and therapeutic effects
of drugs
b) The study of absorption, distribution,
metabolism and excretion of drugs
c) The study of mechanisms of drug action
d) The study of methods of new drug
development
26. The reasons determing bioavailability are:
a) Rheological parameters of blood
b) Amount of a substance obtained orally and
quantity of intakes
c) Extent of absorption and hepatic first-pass
effect
d) Glomerular filtration rate
27. Biotransformation of the drugs is to render them:
a) Less ionized
b) More pharmacologically active
c) More lipid soluble
d) Less lipid soluble
28. Pharmacodynamics involves the study of
following EXCEPT:
a) Biological and therapeutic effects of drugs
b) Absorption and distribution of drugs
c) Mechanisms of drug action
d) Drug interactions
29. Pharmacodynamics involves the following?
a) Information about main mechanisms of drug
absorption
b) Information about unwanted effects
c) Information about biological barriers
d) Information about excretion of a drug from
the organism
30. Pick out the answer which is the most
appropriate to the term “receptor”
a) All types of ion channels modulated by a drug
b) Enzymes of oxidizing-reducing reactions
activated by a drug
c) Active macromolecular components of a cell or
an organism which a drug molecule has to
combine with in order to elicit its specific effect
d) Carriers activated by a drug
31. Pharmacology emerged as its own discipline
in
a. 18th century
b. 15th century
c. 19th century
d. None of the above
e. I don’t know
31. What does the term “potentiation” mean?
a) Cumulative ability of a drug
b) Hypersensitivity to a drug
c) Fast tolerance developing
d) Intensive increase of drug effects due to their
combination
32. Characteristic unwanted reaction which isn’t
related to a dose or to a pharmacodynamic
property of a drug is called:
a) Idiosyncrasy
b) Hypersensitivity
c) Tolerance
d) Teratogenic action
33. If one drug antagonizes the action of other drug
by interacting with different receptor, the
antagonism may be called as;
A. Chemical antagonism
B. Physiological antagonism
C. Pharmacological antagonism
34. Antagonism may be called as competitive if;
A. Both drugs have different receptors
B. Both drugs has affinity for the same receptors
C. Both drugs interact chemically
35. The discipline of pharmacology dealing with
mode of action of drug is known as;
A. Pharmacotherapy
B. Pharmacy
C. Pharmacodynemics
36. Drugs bound to plasma proteins;
A. Can leave vascular space
B. Is eliminated early
C. Is inactive pharmacologically
ELITE INTERNATIONAL COLLEGE OF HEALTH d. Mineral
SCIENCE AND TECHNOLOGY ZARIA e. chemical
100 LEVEL SECOND SEMESTER EXAMINATION 8. Which of this is as a result of immunological
response
SESSION: 2023/2024
a. Side effect
COURSE: ACTION AND USES OF COMMON b. Depression
MEDICINE c. Addiction
DEPARTMENT PHARMACY MARKS 60 d. Hypersensitivity
TIME: 2HRS Type a 9. One of this is not a natural sources of drugs
1. Pharmacology is __________________ a. Plant
a. The study of drugs in nonliving things b. Animal
b. The study of substances and their effect in c. Mineral
living things d. Herbal
c. The study of chemical substances in nonliving e. synthetic
organism 10. The term pharmacology is derived from the word
d. The study of drugs in both living and a. Pharmacon
nonliving plant b. Pharmakon
e. None of the above c. All of the above
2. Metabolism is_______________ d. None of the above
a. A process in nonliving thing 11. The founder of modern pharmacology is
b. Not biotransformation a. Oswald Schmiedeberg (1840-1926)
c. The only important process that drugs b. Oswald Schmiedeberge (1833-1925)
undergoes in the body c. Oswald Schmiedeberge (1838-1921)
d. A process that convert drugs/medicines for d. All of the above
development of new drug e. None of the above
e. A parameter of pharmacokinetics 12. A substance that helps restore you to normalcy is
3. The place where a drug causes an effect to occur called?
is called__________________ a. Drugs
a. Site of action b. Medicines
b. Site of administration c. Poisons
c. Therapeutic window d. All of the above
d. Minimum toxic effect e. a and b
4. Side effect is______________ 13. ………………..describes how medicines moves from
a. An extension of the pharmacological effect of site of administration to the site of action
a drug a. Distribution
b. Not an extended pharmacological effect of the b. Metabolism
drug c. Absorption
c. Is the harmful effect of a drug d. Receptor affinity
d. Same as idiosyncrasy e. Excretion
e. Same as therapeutic effect 14. Elimination of the drug can occur through the
5. Receptor affinity is a term following except
a. Referring to the ability for the receptor to a. Kidney
produce response b. Skin
b. Referring to the response produced by a drug c. Lungs
c. Referring to the ability for a drug to bind to d. Breast milk
the receptor e. Heart
d. Referring to efficacy 15. All the following are sources of medicines except
e. Referring to effectiveness of a drug a. Plants
6. The pharmacokinetic phase is b. Animals
a. The form of the drug c. Bacterial
b. The way the drug is absorbed, distributed, d. All of the above
metabolized, and eliminated e. None of the above
c. The effect of the drug has on the body 16. The pharmaceutical preparations in which a
d. All of the above specific mixture of drug substances are presented
7. Cocaine is an example of drug from to facilitate easy and accurate administration and
____________________source delivery of active drug substances is called
a. Animal a. Packed form
b. Plant b. Dosage form
c. Semi-synthetic c. Dose
 d. All of the above
e. None of the above
17. Food can also potentiate the effects of a drug?
True or false
18. All of the following are animal sources of
medicine except
a. Insulin
b. Heparin
c. Digoxin
d. Cyanocobalamin
e. Vasopressin
19. The science which deals with the drug and their
action on human body is called-
(a) Physiology
(b) Pathology
(c) Pharmacology
(d) Microbiology
20. The study of absorption, distribution, metabolism
and excretion of drug is known as-
(a) Pharmacy
(b) Pharmacokinetics
(c) Pharmacodynamics
(d) Pharmacopoeia
21. Which of the following is a source for obtaining
drugs-
(a) Animals and plants
(b) Micro-organisms
(c) Synthetic origin
(d) All of the above
22. What does “pharmacokinetics” include?
a) Complications of drug therapy
b) Drug biotransformation in the organism
c) Influence of drugs on metabolism
processes
d) Influence of drugs on genes
23. What does the term “bioavailability” mean?
24. a) Plasma protein binding degree of substance
b) Permeability through the brain-blood
barrier
c) Fraction of an uncharged drug reaching the
systemic circulation following any route administration
d) Amount of a substance in urine relative to the
initial doze
25. Biotransformation of a medicinal substance
results in:
a) Faster urinary excretion
b) Slower urinary excretion
c) Easier distribution in organism
d) Higher binding to membranes
26. Pharmacodynamics involves the study of
following?
a) Mechanisms of drug action
b) Biotransformation of drugs in the organism
c) Distribution of drugs in the organism
d) Excretion of drug from the organism
27. Pharmacodynamics involves the study of
following?
a) Mechanisms of drug action
b) Biotransformation of drugs in the organism
c) Distribution of drugs in the organism
d) Excretion of drug from the organism
28. What does “affinity” mean?
a) A measure of how tightly a drug binds to plasma
proteins
b) A measure of how tightly a drug binds to a
receptor
c) A measure of inhibiting potency of a drug
d) A measure of bioavailability of a drug
29. Which effect may lead to toxic reactions when a
drug is taken continuously or repeatedly?
a) Refractoriness
b) Cumulative effect
c) Tolerance
d) Tachyphylaxis
30. What term is used to describe a more gradual
decrease in responsiveness to a drug, taking
days or weeks to develop?
a) Refractoriness
b) Cumulative effect
c) Tolerance
d) Tachyphylaxis
31. What phenomenon can occur in case of using a
combination of drugs?
a) Tolerance
b) Tachyphylaxis
c) Accumulation
d) Synergism
32. If two drugs with the same effect, taken
together, produce an effect that is equal in
magnitude to the sum of the effects of the drugs
given individually, it is called as:
a) Antagonism
b) Potentiation
c) Additive effect
d) None of the above
33. Biotransformation of the drugs may lead to all of
the following except
a) Inactive metabolite from an active drug
b) Active metabolite from an active drug
c) Active metabolite from an inactive drug
34. Pharmacy deals with;
A. Mechanism of action of drug
B. Preparation of drug
C. Identification of drug
35. 1st pass effect;
A. Increase the bioavailability of the drugs
B. Decrease the bioavailability of the drugs
C. Increase the excretion of drugs
36. Drug allergy refers to those situations in which
unusual response is due to;
A. Over dose
B. Wrong rout of administration
C. Antigen-antibody reaction