Course Curriculam

Course Code: BIOF404 Credit Units L T P/S SW AS/DS FW No. of PSDA Total Credit Unit
Course Level UG 2 0 0 0 0 0 0 2
Course Title Immunoinformatics

Course The course is a combination of immunological studies with bioinformatics strategies for computational driven immunological research.
Description :

Course Objectives :

SN. Objectives
1 This course will enable the students to acquire skill set for insilico immunological studies.

Pre-Requisites : General

Course Contents / Syllabus :

SN. Module Descriptors / Topics Weightage

Introduction to
Introduction to immunology & Bioinformatics, immunoinformatics, the immune system, cellular immunity,
Immunoinformatics
1 antibody mediated immunity. Immunological databases-dbMHC-MHC database at NCBI, T-cell epitope 35.00
and Immunological
databases, B-cell epitope databases. SYFPEITHI MHC-presented epitopes.
Databases
Experimental and theoretical description of peptide-MHC binding, selection of epitopes using bioinformatics,
2 Immunological Tools prediction of proteasome processing, and TAP binding, Predictions of Class I and Class II MHC Epitopes, 35.00
IEDB analysis Resourse, CTLPred, Population Coverage analysis, Epitope conservancy analysis.
Introduction to vaccines, Different generations of Vaccines, Concepts of reverse vaccinology, case study of
Computational
3 Reverse Vaccinology with Meningococcus B, Comparision of Traditional Vaccinology and Reverse 30.00
Vaccinology
Vaccinology, Tools & servers for computational Vaccine design-from Genome to Vaccine.

Course Learning Outcomes :

SN. Course Learning Outcomes

The students will have knowledge of immune responses to various pathogens by integrating genomics and proteomics with bioinformatics
1
strategies.
2 The student will be proficient in computer aided vaccine design.

Pedagogy for Course Delivery :

SN. Pedagogy Methods

1 Lectures:26
2 Presentation/ Seminar: 2
3 Class Test: 2
Theory /VAC / Architecture Assessment (L,T & Self Work): 100.00 Max : 100

Attendance+CE+EE : 5+45+50

SN. Type Component Name Marks

1 Attendance 5.00
2 End Term Examination (OMR) 50.00
3 Internal CLASS TEST 20.00
4 Internal HOME ASSIGNMENT 10.00
5 Internal PRESENTATION 10.00
6 Internal CLASS QUIZ 5.00

Lab/ Practical/ Studio/Arch. Studio/ Field Work Assessment : 0.00 Max : 100

N/A

List of Professional skill development activities :

No.of PSDA : 0
N/A

Text & References :

SN. Type Title/Name Description ISBN/ URL

• Immunoinformatics: Bioinformatic
1 Book Strategies for Better Understanding of 978-0470853566
Immune.
• Predicting Immunogenicity In Silico
2 Book 978-1588296993
Series.