MEQ GIT Bank

1- Why liver ability to synthesize VLDL is impaired with sratvation?

Answer: Due to decreased rate of protein synthesis under influence of low insulin

2- Define lipotropic factors?

Answer:

Substance that mobilize TAG from liver to extrahepatic tissues

3- Explain ammonia is toxic to the brain?

Answer:

- Hypo energy of the brain due to depletion of NADH+ and alfa keto glutarate
- Increase glutamine synthesis
- Increase glutamate synthesis

4- What is the main coenzyme for aminotransferase enzymes?

Answer:

Pyridoxal phosphate (PLP)

5- Explain niacin deficiency with carcinoid syndrome?

Answer:

Due to shifting of tryptophan to serotonin pathway

 6- Mention enzyme deficient in albinism?

Answer:

Tyrosinase

7- Enumerate amino acids involved in synthesis of creatine?

Answer:
Glycine, active metionine and argnine

8- Mention deficient enzyme in Homocystinuria?

Answer:

Cystathionine synthetase

9- NH3 is removed from brain mainly by …………………

Answer : Glutamine formation

10- Histidine is converted to histamine through the process of ………

Answer: Decarboxylation

11- Transamination of oxaloacetate results in the formation of:

Answer: Aspartic acid

12- The main sites for oxidative deamination are

Answer: Liver and kidney

13-Which of the following amino acids defects results in maple syrup urine
disease?

Answe: Branched chain amino acids

14- What is the major cause of death In homocystinuria ?

Answer :Thrombosis is

15- The major methyl donor in methylation reactions is :

Answer : S-adenosyl methionine .

16- Transmethylation of guanido acetic acid gives:

Answer: Creatine phosphate