Improving Health Through The Nervous System

Cytokines are powerful communication molecules capable of regulating a wide spectrum of biological functions, including a crucial role in the immuno-pathogenesis of disease. Two general constellations of cytokines are associated with functional immune responses. These are classified as either TH1 or TH2 and can be distinctly observed during disease. Cytokine TH1
IL-2 IL-12 IFNTNFInterleukin-2 Interleukin-12 InterferonTumor necrosis factorInflammation Autoimmune diseases (RA, MS, IDDM), tumor, Graft vs. Host Disease, Infections, HIV, Glomerulonephritis Inflammatory diseases (infection, Dermatitis), autoimmune diseases (RA, MS, IDDM, SLE), tumors, Hepatitis B and C Inflammatory diseases, autoimmune diseases (RA, IDDM, MS, CD), Psoriasis, chronic Hepatitis B and C, SLE, tumors, chronic lymphatic Leukemia, Schizophrenia

Disease*

TH2
IL-4 IL-5 IL-6 IL-10 IL-13 GM-CSF Interleukin-4 Interleukin-5 Interleukin-6 Interleukin-10 Interleukin-13 Granulocyte-macrophage colonystimulating Factor Asthma, Allergy, Malaria, Hepatitis C Asthma, Allergy Inflammatory diseases (viral and bacterial infection), autoimmune disease (RA, SLE, etc.), Schizophrenia Autoimmune disease, IgE-mediated Asthma, Hepatitis B and C, IBD, Septic shock, mostly during recession of diseases Asthma, Allergy, COPD Inflammation (bacterial infection, Asthma), autoimmune diseases, toxic shock

TH17
IL-17 Interleukin-17 Inflammatory diseases (inflammatory airway diseases), autoimmune diseases (RA, MS, Crohns Disease, etc)

Other
IL-1 IL-7 IL-8 G-CSF MCP-1 MIP-1 TGFInterleukin-1 Interleukin-7 Interleukin-8 Granulocyte colony stimulating factor Monocyte chemoattractant protein-1 Macrophage inflammatory protein-1 Transforming growth factorsInflammatory diseases (Periodontitis, Colitis, IBD), autoimmune diseases (RA, IDDM, MG), Schizophrenia Osteolytic Cancer, Lymphopenia, high in untreated advanced HIV patients and in those who fail to respond to HAART therapy Autoimmune diseases (RA, Crohns disease), Uveitis, Colitis, acute inflammatory diseases Acute bacterial infection, cyclic neutropenia Inflammatory diseases (Glomerulonephritis, Allergy), Atherosclerosis, Neoplasm, human immunodeficiency infection, autoimmune diseases (RA, MS), Alzheimers disease Acute infections such as bacterial Sepsis, Plasmodium, HIV, lung diseaseSarcoidosis, autoimmune diseases (RA, MS), Colitis, Asthma Inflammation, wound healing, bone formation, fibrotic conditions, carcinogenesis, immunosuppressive disorders, neurodegenerative disease, coronary artery disease, SLE, RA

*This chart is not to be used for diagnostic purposes. This is only for general information on the role cytokines might play in human disease.

Pro-inflammatory cytokines IL-1 , IL-2, IL-6, IL-8, IL-12, IL-17, IFN- , TNF-

Anti-inflammatory cytokines IL-4, IL-5, IL-10, IL-13, TGF-

Chemokines IL-8, MCP-1, MIP-1

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