Periodontitis and implant complications in diabetes - PubMed 7/16/24, 4:12 PM

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Review Periodontol 2000. 2022 Oct;90(1):88-105. doi: 10.1111/prd.12451. Epub 2022 Aug 1.

Periodontitis and implant complications in diabetes

Luigi Nibali 1 , Nikolaos Gkranias 2, Giuseppe Mainas 1 , Antonino Di Pino 3

Affiliations
PMID: 35913467 PMCID: PMC9805043 DOI: 10.1111/prd.12451

Abstract
Epidemiologic evidence indicates that periodontitis is more frequent in patients with uncontrolled
diabetes mellitus than in healthy controls, suggesting that it could be considered the "sixth
complication" of diabetes. Actually, diabetes mellitus and periodontitis are two extraordinarily
prevalent chronic diseases that share a number of comorbidities all converging toward an increased
risk of cardiovascular disease. Periodontal treatment has recently been shown to have the potential
to improve the metabolic control of diabetes, although long-term studies are lacking. Uncontrolled
diabetes also seems to affect the response to periodontal treatment, as well as the risk to develop
peri-implant diseases. Mechanisms of associations between diabetes mellitus and periodontal
disease include the release of advanced glycation end products as a result of hyperglycemia and a
range of shared predisposing factors of genetic, microbial, and lifestyle nature. This review
discusses the evidence for the risk of periodontal and peri-implant disease in diabetic patients and
the potential role of the dental professional in the diabetes-periodontal interface.

Keywords: diabetes; peri-implantitis; periodontitis.

© 2022 The Authors. Periodontology 2000 published by John Wiley & Sons Ltd.

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