Chriomaomau) cbaurtaton

rtrto0g@mant mony 2Rnes

" h prrosen
hromoJm mauKeJ a Change e) chemoom
chromdon
On a Sn
endoruatco) to ottut. nene
Numloert ord in gent
lrohongea
oullo o c u to thange sh thream0-
thoremocHon eu tADmo JOma
en tomo JOmR
iucdurreol ehonge
dome 3AruUurt.
ChrtomD&omeu numbes, c
doemt mrough he LOB
ortomobomalmgt artt'CL
but n heur
rertunmtnt Partkt uuloaut s t t o
Ort aoddu m ot

Chromo&ome.
honge co hromoOTn
So he oS
or
4utmeel u
mud-euttoD
ttCLrtrtngtnen
ort hreomNDÝ mal
ChtonDbomo
Claifec undorn
hehrtomobcmay eubbirtoit-uy artaefrcom
ontehs en mo be f t h oALswtny t r .
(A) Chang invtlving the no. G22n leu

C De3unuon deeay (a OuputCl) ot aclcu'&cp

 b) gmeyt gRn
Lnge. votwna.tho eLruOLn

Meuhondsy oletaill
A)C) Dehutoiert deloeer)

bLOn conteuniy soveru 2ent. 2

Her h loraok thrpmo20m mabe couueo b
3 a L4ens súuh C them'coLs olrug &

ype olelakdn

a ) erminau eletoko)

ne u Chrtomoboma.
r ngl bu nve weo.
Th 4erimin o eten+ cur hromprom

D fS H

on n4rutdaou elllAla)
Cbn+ercau
invoLv 9 t h os
173
an
wth +he t
thromoom
OTHh.
a 3a

Ptrhs
anorunicy ermda
 breoAh

A C Def H
Last
A D C H

Sioanitan d oleem e8~et

S o m a o l e A 1 r e D U

Dlako houwe

muu noe doh rLo m D & o o

anous) h
oioeo b he
7 morno Rogeo
chang
olQtteulolR

to +th
orani.
Mndeurt
dus suolomun enu
4

ort
oLolclude
) Dupukee0 moreheun
onte th
bloth U{ en
prtesene. ta upud-on unol the
compiunent tnDum e tR o e e f
haLpioeel tnowrn

hrtompdym
h t o m p d ) m L

+ ge+
i h t 9et
frcor oneOne

7h oleetee Porho h r e o m o o m
h pcu gr

to he oHher

h r Cr
Chronmogoml degmant.
4teuh ment N
T n c e m oupioken tama genAHe
ho
aololoe + ha

& h aolel
Horuna
P
1
 Ler the saautnc gene. eulunao
cuteuh chromoomaduatroweru He Jen atam

Oupitom. A

CDspRouco elupticcu)
=

Hn Ah Chrtome to mal ment

HahRoto dome noo homo Lo gouChromorom.
L NA

h NOAeo) n e gon moLlerue

Duucoukdsy oB thromoxme dnot olatteruow to
he ortg Linoltuan buutha Prtoteut

Lourtg o l u k o p oLn taou he Aettt cnol

t 4hdwy ralut 4h owo prtobabi'Lthy

Swwtva.
hrbodM meuertu'a whor (
Reoton
uLurung ts L u th ag aiteroel

C rranslotu
TrtonLOLO0Dnvoi th shih
Pat on hrtDmoom t0hO
a
esunother non
hromoYom Ortc ira
homooo.
n g m t C9 uhu'ch
ChonO tomou
r o on Lnhy ro. rans tortt to anoo
Lhage aroup,

h r e e M D dOML SRMn+ Jnon-hmoRonay cungg

romdw
out
Ca) snple c0ansLooton
4ho Cn maul soamon 6 a chrtonmo rome i
aololo ho nd of o4hort non- homologau Uhromotome .
Ths
ths t e very rara ano t cauueo ahaa
ft on ehtombhpm. nly

H S L

D f
C H J
Cb) Shf+ trranstocakton

chrtomobon bruohD s6 cino 'snertteo wthth h e

orouK en aunothort no homølo hrtomøtonme. do c
envolve 3 bro0ins, duo onehromoom ano ne th
no honmo leouus hromoJDM.

C
Reciprtotoal tronsoeL)
4 tho ohang c pearcs be ho
d dw tRe
non hanologous thrmo0ma
i) HOmoz0w ruprroeou n thd ongo both h homalp40u
tha u o hom olo
ChrionDme Qohang g r s weth
noht paurtA
C) HR DrzA 2OW roupnoCOu HRro ony one m@naert
faur enehon g a part.
 C E JkL

ttonod
C D

H 1 JE H2 J E
H 1 J

h a RroHOUs 4tgnlooLHD frrocuco simasterul

oadam batuusa, ald hu a d Aum4R eu's
torwcive Fuu mpRmants stn rtreo K
ha noumcu dNalopment ofen,
t h henDtypit prdur) san mybe mbouo
Cehon trounULooLLRo

49nom
PLy th n HLcnt rrol to the #oremoukn

)nver St0 r o he seqionR gonu, uhuth

eureothe otat) UF blc a chaoame
180
eru a hcomoomehautng alingmen+

mdlcldsmont.Cotf anolorgoR3 hveDuc), th

Alorcmu thromoBDni
priea
foh
lnverto chrumer
(a) fcutca Cenirtit cn veren
wnt both the ortou tn he hecemoron oluuruhqAN ROVerd

enour as pcucaLntrue.
pute contrul thvercho) occut seh gl ie. 4ha oesll
e contrtomirna lon bnocor) cuN tretal ort
hoportachuou.
u o LreCntteiathvExHUn ocut; ona do ha arthor sda
hCootcomoah tendg rauy as htercnaoliy o
brcuhiay nveruen
pourteu ntu invertnm, the hyerkeol egmont dt Chrebmcm
. 5
weth out tinrtomere
(b)Peticanttic n veresto
etrromLT k. it nvolvs on orALOL out uf 4uo lotuA

Chrrpnpomau,AleLoornau Allelolorcanthucul,&Helertonomu overkm

7 neruin otut t &ngl chromoom@ d noury Chrtimn
coverhm thromwIm
nverrion ocuthg h both +he hombiogo
Ca AllLDaDmud. MRA00
homoLpgous Curons f
7HutD bomaL thverscn ouuru
romodm, lonoum
7weriUn occurung tn non- hpmakegou
oheroBUma) smverio).

StaniLNR Senverm

FthoFdut ehrcemakd
ortt he vcow h t HteD
erogo
a rwe tnverno) ehang Cro AOvert a r
Lei
thoreord Hhe reombrepean ut senak¢
rstruteel, tnuerunen stndLan t0 truuloCLeg hef e)
2eLhlarn heues rulm tn Oroophelta',