THE TAMIL NADU DR. M.G.R.

MEDICAL UNIVERSITY

(LP 2014) SEPTEMBER 2019 Sub. Code: 2014

B.PHARM. DEGREE EXAMINATION

PCI Regulation  SEMESTER II
PAPER I – HUMAN ANATOMY AND PHYSIOLOGY – II

Q.P. Code: 562014

Time: Three hours Maximum: 75 Marks

I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

1. Name the four surface lobes of the Cerebral hemisphere and describe the functions
of the Cortex in each lobe.
2. Explain about the anatomy and physiology of Digestive system.
3. With illustrated diagram explain about the structure and function of a Nephron.

II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)

1. Explain about the mechanism of hormone action.

2. Discuss about the internal structure of the female reproductive system with
diagram.
3. Describe about Oogenesis.
4. Write a brief note on pregnancy and parturition.
5. Genetic pattern of inheritance.
6. Write a note on neurotransmitter receptors with examples.
7. Discuss about the process of acid regulation in digestive system.
8. Discuss about the formation and role of ATP.
9. Name the various functions of the respiratory system.

III. Short answers on: Answer ALL questions. (10 x 2 = 20)

1. Functions of cerebellum.
2. Parts of Stomach.
3. Gall bladder.
4. Inflammatory Bowel Disease.
5. Naso pharynx.
6. Carbondioxide transport in blood.
7. Urinary Bladder.
8. Diabetic nephrophathy.
9. Vasopressin.
10. Diabetes mellitus.

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 THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY

(LP 2016) SEPTEMBER 2019 Sub. Code: 2016

B.PHARM. DEGREE EXAMINATION

PCI Regulation – SEMESTER II
PAPER II – PHARMACEUTICAL ORGANIC CHEMISTRY – I

Q.P. Code: 562016

Time: Three hours Maximum: 75 Marks

I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

1. Explain the mechanism, reactivity and kinetics of SNI reaction.

2. Explain Perkin condensation with mechanism and examples.
3. Explain the mechanism of free radical addition reaction of alkenes with examples.

II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)

1. Explain the basicity of amines.

2. Halogenation of alkanes.
3. Ozonolysis.
4. Explain Saytzeffs rule with examples.
5. Explain the mechanism of cannizaro reaction with examples.
6. E1 versus E2.
7. Describe in detail about electrophilles and nucleophilles with examples.
8. Differentiate between primary, secondary, tertiary amines.
9. Explain about hybridization. Describe the molecular orbital structure of ethane.

III. Short answers on: Answer ALL questions. (10 x 2 = 20)

1. Define and classify alcohols.

2. Define hydrogen bonding with one example.
3. Structure and use of ethylene diamine.
4. 1, 4 addition of conjugated dienes.
5. Why aniline is less basic than ammonia?
6. Structure and use of vanillin and propylene glycol.
7. Qualitative test for amides.
8. IUPAC name of HO – CH2-CH2-CH2 – COOH.
9. Medicinal uses and structure of Lactic acid and amphetamine.
10. General test to identify acetone and benzyl alcohol.

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 THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY

(LP 2018) SEPTEMBER 2019 Sub. Code: 2018

B.PHARM. DEGREE EXAMINATION

PCI Regulation – SEMESTER II
PAPER III – BIOCHEMISTRY

Q.P. Code: 562018

Time: Three hours Maximum: 75 Marks

I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

1. Describe transamination and deamination reactions with suitable examples.

2. Explain Embden Meyerhof pathway and write its significance.
3. How genetic code is used for amino acid coding and explain with wobbles
hypothesis?

II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)

1. Discuss and detail about the Redox potential.

2. What are phospholipids? Describe the classification and functions of any two
Phospholipids.
3. Synthesis and significance of Melatonin.
4. Explain Hyperbilirubinemia and Jaundice.
5. Bio-synthesis of De-novo pathway of purine and explain any one metabolic
disorder of purine.
6. Explain Enzyme kinetics with Michaelis plot.
7. Explain allosteric enzymes regulation.
8. Hexose Monophosphate pathway.
9. Explain the conversion of cholesterol into steroid hormones and write its
significance.

III. Short answers on: Answer ALL questions. (10 x 2 = 20)

1. What is Atherosclerosis?
2. Define Bio molecules.
3. Diabetes Mellitus.
4. What are exergonic reaction?
5. What is cellular respiration?
6. What is albinism?
7. Differentiation mRNA & tRNA.
8. Define coenzymes.
9. Creatinine.
10. Lipoprotein.

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 THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY

(LP 2020) SEPTEMBER 2019 Sub. Code: 2020

B.PHARM. DEGREE EXAMINATION

PCI Regulation – SEMESTER II
PAPER IV – PATHOPHYSIOLOGY

Q.P. Code: 562020

Time: Three hours Maximum: 75 Marks
I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

1. Discuss about the various inflammatory mediators and their role in inflammatory
process.
2. Describe the etiology and pathophysiology of congestive heart failure.
3. Elaborate on etiopathogenesis of iron deficiency anemia and megaloblastic
anemia.

II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)

1. Etiology of various types of viral hepatitis.

2. Enumerate on pathophysiology of gout.
3. Write a note on etiopathogenesis of AIDS.
4. Define meningitis and write about different types of meningitis.
5. Write a note on various stages of alcoholic liver disease.
6. Enumerate on pathophysiology of Parkinson’s disease.
7. Write causes and pathogenesis of acute renal failure.
8. Describe the different types of necrosis.
9. Write about various stages of urinary tract infection.

III. Short answers on: Answer ALL questions. (10 x 2 = 20)

1. Define metaplasia with suitable example.

2. Cause and prevention of Gonorrhea.
3. Write the causes of extrinsic asthma.
4. List the etiology of peptic ulcer.
5. Grave’s disease.
6. Write the causes of Osteoporosis.
7. Classify inflammatory bowel disease.
8. Define epilepsy.
9. Causes and prevention of typhoid.
10. What is wound healing?

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 THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY

[BPHARM 0321] MARCH 2021 Sub. Code: 2014

(SEPTEMBER 2020 EXAM SESSION)
B. PHARMACY DEGREE EXAMINATION
PCI Regulation SEMESTER  II
PAPER I – HUMAN ANATOMY AND PHYSIOLOGY – II
Q.P. Code : 562014

Time: Three hours Maximum: 75 Marks

I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

1. a) Describe anatomy and physiological functions of Thyroid gland.

b) Explain the consequence of hypothyroidism and hyperthyroidism.

2. Discuss in detail the anatomy and functions of Male reproductive system.

3. Write in detail about physiology of Urine formation. Adds a note on micturition.

II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)

1. Write about Oogenesis.

2. Enlist the function of the Liver.
3. Give the composition and function of Cerebrospinal fluid.
4. Add a note on artificial respiration.
5. Describe organization of the Nervous system.
6. Reflex action.
7. Define and classify hormones.
8. Discuss Fertilization.
9. Role of Renin Angiotensin system in kidney.

III. Short answers on: Answer ALL questions. (10 x 2 = 20)

1. Give the composition of bile.

2. Function of neuroglia.
3. Define vital capacity.
4. What is Spermatogenesis.
5. What is GFR. Give its normal values.
6. Hormones of parturition.
7. Draw a neat diagram of neuron and label it.
8. List out the properties of nerve fiber.
9. What is the importance of meninges.
10. Functions of Cerebrum and Cerebellum.

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 THE TAMIL NADU Dr.M.G.R. MEDICAL UNIVERSITY

(LQ 2016) MARCH 2020 Sub. Code: 2016

B.PHARM. DEGREE EXAMINATION

PCI Regulation – SEMESTER II
PAPER II – PHARMACEUTICAL ORGANIC CHEMISTRY – I

Q.P. Code: 562016

Time: Three hours Maximum: 75 Marks

I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

1. Discuss Sp2 hybridization in alkenes.

2. a) Give the method of preparation of Carboxylic acid.
b) Acidity of carboxylic acid.
3. a) How will you distinguish primary, secondary and tertiary amines?
b) Discuss the basicity of amines.

II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)

1. How are aldehydes prepared? Give their important reactions.

2. Give the method of preparation on allyl halide.
3. Give some important reactions of alcohols.
4. Write about the effect of substituent on acidity of carboxylic acid.
5. Write a note on benzoin condensation.
6. Explain SN1 reaction.
7. Write about IUPAC rules for naming cycloalkanes.
8. Write a note on Peroxide effect.
9. Write about conjugated dienes.

III. Short answers on: Answer ALL questions. (10 x 2 = 20)

1. Define ozonolysis.
2. How will you distinguish 1-butyne and 2 butyne?
3. Give the structure and uses of chloroform.
4. Write the structure and use of: a) Cetosteryl alcohol b) Glycerol.
5. Define Cannizzaro reaction.
6. Give the structure and use of: a) Hexamine b) Vanillin.
7. Define inductive effect.
8. What happens when methane is treated with Iodine in presence of an oxidizing
agent HIO3?
9. Write the structure of the following: a) 1-methyl pentene b) 2-ethyl butane.
10. Define Isomerism.

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 THE TAMIL NADU Dr.M.G.R. MEDICAL UNIVERSITY

(LQ 2018) MARCH 2020 Sub. Code: 2018

B.PHARM. DEGREE EXAMINATION

PCI Regulation – SEMESTER II
PAPER III – BIOCHEMISTRY

Q.P. Code: 562018

Time: Three hours Maximum: 75 Marks

I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

1. Explain the De novo synthesis of Palmitic acid.

2. Define Oxidative Phosphorylation. What is the cellular site of Oxidative
phosphorylation?
3. Explain the steps involved in Biosynthesis of Nucleotide.

II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)

1. Write a note on the Pathway of synthesis Catecholamines.

2. Describe Urea Cycle.
3. Explain Inhibitors of Protein synthesis.
4. Write short note on NAD+ and NADP+.
5. Heme.
6. Write the conversion of cholesterol to Vitamin D3.
7. Explain Bioenergetics and concept of free energy.
8. Explain in detail about the clinical significance of Isoenzymes.
9. What are Glycolipids? Explain with suitable examples.

III. Short answers on: Answer ALL questions. (10 x 2 = 20)

1. Explain Endergonic reactions.

2. Write the significance of ATP.
3. Hypercholesterolemia.
4. Ketone bodies.
5. Alkaptonuria.
6. Gout.
7. What are essential fatty acids?
8. Define codons.
9. Define lysosomes.
10. Write the therapeutic applications of enzymes.

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 THE TAMIL NADU Dr.M.G.R. MEDICAL UNIVERSITY

(LQ 2020) MARCH 2020 Sub. Code: 2020

B.PHARM. DEGREE EXAMINATION

PCI Regulation – SEMESTER II
PAPER IV – PATHOPHYSIOLOGY

Q.P. Code: 562020

Time: Three hours Maximum: 75 Marks
I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

1. Describe on pathogenesis and morphology of Cell injury.

2. Define Asthma. Write the causes, symptoms and pathophysiology of Asthma.
3. Describe the etiology and pathophysiology of acute renal failure.

II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)

1. Discuss about the various Mediators of Inflammation.

2. Write notes on Epilepsy.
3. Describe briefly on Rheumatoid Arthritis.
4. Pathogenesis of Acquired Immunodeficiency Syndrome.
5. Explain Homeostasis and the concept of Negative feedback.
6. Enumerate on the Pathogenesis of Cancer.
7. Discuss the mode of transmission and pathophysiology of Leprosy.
8. Notes on Stroke and its etiology.
9. Write notes on Meningitis.

III. Short answers on: Answer ALL questions. (10 x 2 = 20)

1. Haemolytic Anemia.
2. Hyperplasia.
3. Grave’s disease.
4. Various stages of Chronic Kidney Disease.
5. Pathogenesis of Gout.
6. Define Goitre.
7. Acromegaly.
8. Angiogenesis.
9. Types of Acute Myocardial Infarction.
10. Ejection fraction.

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 THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY

[BPHARM 0321] MARCH 2021 Sub. Code: 2014

(SEPTEMBER 2020 EXAM SESSION)
B. PHARMACY DEGREE EXAMINATION
PCI Regulation SEMESTER  II
PAPER I – HUMAN ANATOMY AND PHYSIOLOGY – II
Q.P. Code : 562014

Time: Three hours Maximum: 75 Marks

I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

1. a) Describe anatomy and physiological functions of Thyroid gland.

b) Explain the consequence of hypothyroidism and hyperthyroidism.

2. Discuss in detail the anatomy and functions of Male reproductive system.

3. Write in detail about physiology of Urine formation. Adds a note on micturition.

II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)

1. Write about Oogenesis.

2. Enlist the function of the Liver.
3. Give the composition and function of Cerebrospinal fluid.
4. Add a note on artificial respiration.
5. Describe organization of the Nervous system.
6. Reflex action.
7. Define and classify hormones.
8. Discuss Fertilization.
9. Role of Renin Angiotensin system in kidney.

III. Short answers on: Answer ALL questions. (10 x 2 = 20)

1. Give the composition of bile.

2. Function of neuroglia.
3. Define vital capacity.
4. What is Spermatogenesis.
5. What is GFR. Give its normal values.
6. Hormones of parturition.
7. Draw a neat diagram of neuron and label it.
8. List out the properties of nerve fiber.
9. What is the importance of meninges.
10. Functions of Cerebrum and Cerebellum.

*******
 THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY

[BPHARM 0321] MARCH 2021 Sub. Code: 2016

(SEPTEMBER 2020 EXAM SESSION)
B. PHARMACY DEGREE EXAMINATION
PCI Regulation SEMESTER  II
PAPER II – PHARMACEUTICAL ORGANIC CHEMISTRY I
Q.P. Code : 562016

Time: Three hours Maximum: 75 Marks

I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

1. Discuss the mechanism of E1 and E2 reactions of alkyl halides.
2. Explain in detail classification of organic compounds with common and IUPAC
system of nomenclature of organic compounds.
3. Write short notes on:
a) Give the method of preparation of alcohol.
b) How to distinguish primary, secondary, tertiary alcohols.

II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)

1. Write a note on Sp2 hybridization in alkenes.
2. Write a note on ozonolysis.
3. Discuss the reaction of salts of carboxylic acid.
4. Write in detail about structural isomerism with examples.
5. Explain Saytzeff’s rule.
6. Write about cannizzaro reaction.
7. Explain Perkin’s condensation.
8. What are amines and give the classification of it with examples.
9. What is Markownikoff’s rule of addition.

III. Short answers on: Answer ALL questions. (10 x 2 = 20)

1. What do you mean by Tautomerism.
2. Name the following alkyl gp CH3-CH2-CH2-(CH3)2CH.
3. Write the structural formula of,
a) 2-propenal
b) 2,2,4-trimethylpentene
4. Write the medicinal uses of
a) Benzoyl alcohol
b) Ethanolamine.
5. Write the structure and use of
a) Amphetamine
b) Propylene glycol
6. What is Hinsberg reagent?
7. What is Inductive effect?
8. What is allylic rearrangement.
9. Give the structure and use of Iodoform.
10. Define isomerism.
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 THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY

[BPHARM 0321] MARCH 2021 Sub. Code: 2018

(SEPTEMBER 2020 EXAM SESSION)
B. PHARMACY DEGREE EXAMINATION
PCI Regulation SEMESTER  II
PAPER III – BIOCHEMISTRY
Q.P. Code : 562018
Time: Three hours Maximum: 75 Marks

I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

1. Explain the process of glycogen breakdown pathway.

2. Describe the citric acid cycle with energetic.
3. Explain the metabolic pathway of phenylalanine and Tyrosine.

II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)

1. RNA
2. Explain the coenzymes involving oxidation – reduction reaction.
3. Liphoproteins.
4. Describe the michaelis – menten equation.
5. Explain about glycogen storage diseases.
6. Fatty liver.
7. Biosynthesis of Purine nucleotides.
8. Electron transport chain.
9. Jaundice.

III. Short answers on: Answer ALL questions. (10 x 2 = 20)

1. Albinism.
2. Hypercholesterolemia.
3. Define metabolism.
4. What is the significance of HMP shunt?
5. What is genome?
6. Atherosclerosis.
7. Give any two differences between DNA and RNA.
8. Isoenzymes.
9. Ketone bodies.
10. FMN.

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 THE TAMIL NADU DR. M.G.R. MEDICAL UNIVERSITY

[BPHARM 0321] MARCH 2021 Sub. Code: 2020

(SEPTEMBER 2020 EXAM SESSION)
B. PHARMACY DEGREE EXAMINATION
PCI Regulation SEMESTER  II
PAPER IV – PATHOPHYSIOLOGY
Q.P. Code : 562020
Time: Three hours Maximum: 75 Marks

I. Elaborate on: Answer any TWO questions. (2 x 10 = 20)

1. Describe in detail the etiology and pathogenesis of Congestive Heart Failure.

2. Elaborate on the pathogenesis, etiology and symptoms of any two Psychiatric
Disorders.
3. Discuss in detail the various disorders of Thyroid Gland.

II. Write notes on: Answer any SEVEN questions. (7 x 5 = 35)

1. Write a note on Pathologic Calcification.

2. Acute Myocardial Infarction and its pathogenesis.
3. Discuss briefly on Gout.
4. Enumerate on the pathogenesis of Asthma.
5. Etiological causes of acquired and inherited Aplastic Anaemia.
6. Write short notes on Irreversible Cell Injury.
7. Notes on Chronic Inflammatory Cells and various secretions involved in Chronic
Inflammation.
8. Discuss about the pathogenesis and clinical complications of Rheumatoid
Arthritis.
9. Write notes on Acute Renal Failure.

III. Short answers on: Answer ALL questions. (10 x 2 = 20)

1. Types of Depression.
2. Dysplasia.
3. Homeostasis.
4. Hypokalemia.
5. Haemolytic Jaundice.
6. Cushing’s disease.
7. Epilepsy.
8. Hypertension.
9. Meningitis.
10. Glomerulonephritis.
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