Last edited: 7/31/2022

PHARMACOKINETICS | DRUG DISTRIBUTION

Pharmacokinetics | Drug Distribution Medical Editor: Dr. Ana Guerra

I) REVIEW QUESTIONS WITH ANSWERS

QUESTIONS ANSWERS

1) NN610 is an investigational cholesterol-lowering b) Low

agent. Has a high molecular weight and is extensively
bound to albumin. NN will have a _____ apparent
volume of distribution (Vd)
a) High
b) Low
c) Extremely high
d) Normal

a) 1 L/kg
AfraTafreeh.com
2) A 40-year-old male patient (70 kg) was recently
diagnosed with infection involving methicillin-resistant
S. aureus. He received 2000 mg of Vancomycin dose. The apparent volume of distribution (Vd) for a drug is defined
The peak plasma concentration of Vancomycin was as the hypothetical fluid volume through which the drug is
28.5 mg/L. dispersed. It is calculated by dividing the total amount of
The apparent volume of distribution is: drug given by the concentration of drug in plasma
a) 1 L/kg
(2000 𝑚𝑔/ 70 𝑘𝑔)
b) 7 L/kg 𝑉𝑑 = = 1 𝐿/𝑘𝑔
c) 10 L/kg 28.5 𝑚𝑔/𝐿
d) 14 L/kg
e) 70 L/kg

3) Levodopa is a drug very commonly used to treat c) Hydrophobic

Parkinson’s disease that acts by being converted to
dopamine in the brain. Which property should it have
in order to being able to cross the BBB?
a) Large and polar
b) Large and nonpolar AfraTafreeh.com
c) Hydrophobic
d) Bound to proteins

4) What is the formula to determine Vd of a drug? a)Vd = F x dose / C

a)Vd = F x dose / C
b)Vd = F / dose x C
c)Vd = C x F / C
d)Vd = F + dose / C