Cholecystitis-Pathophysiology 2

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Precipitating factors:

Predisposing factors:
 Severe Stress
 Advanced Age: 72 years old
 Overuse of NSAIDs
 Gender: Family
 Overuse of Corticosteroids
 Genetic Predisposition
 Alcohol Abuse
 Chronic Illness: Hypertension
 Dietary Indiscretion
 Underweight
 Radiation Therapy
 H. pylori Infection
 Ingesting corrosive substances or
 Previous Gastric Surgery
chemicals

Initial Gastric Mucosal Damage Abdominal


Discomfort

Disruption or imbalance in the normal


mucosal barrier function

Heartburn, Increased Gastric Acid


abdominal pain, and Exposure
indigestion

Damage and erosion of the


gastric lining

Inflammation and Cellular Response


GASTROSCOPY RESULT:
G-E Suction:
No mass
Fundus:
No ulcerations Abdominal pain,
Body (A&P):
Moderate As inflammation progresses, indigestion, nausea,
Antrum: superficial defects develop in the
Erythamatosus loss of appetite, and
Pyloric Ring: gastric mucosa
Erosions fatigue
Duodenal Bulb: EGD
Duodenum:
Endoscopic Diagnosis: Acute Gatric
Mucosal Erosions Loss of the surface epithelium and
Recommendations: None exposure of the underlying tissue to
gastric acid and enzymes

CBC:
Blood chemistry:
WBC: 12.3 (high)
Creatinine: 1.37 mg/dl (high)
Segmenters: 0.82 (high)
Remarks: STAT
ACUTE GASTRIC Lymphocytes: 0.13 (low)
MUCOSAL EROSIONS Eosinophils: 0.00 (low)

Sharp, stabbing Weight Loss Nausea & Vomiting


abdominal pain x 10
(Epigastric & right lower
quadrant)
Legend:
Risk factors Disease process Manifestations Disease Lab findings

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