Guduchi

Botanical Name(s): Tinospora Cordifolia Family Name: Meninspermaceae Kingdom: Plantae Division: Magnoliophyta Class: Magnoliopsida Order: Ranunculales Family: Menispermaceae Genus: Tinospora Species: T. cordifolia Popular Name(s): Gulanshe Tinospara, Gulancha Tinospara, Tinospara, Giloy Parts Used: Stem. Habitat: North and South India Plant Chemicals

(+)- diterpene, tinosporone, tinosporic acid, cordifolisides A to E, syringen, berberine, giloin, gilenin, crude giloininand, arabinogalactan polysaccharide, picrotene, bergenin, gilosterol, tinosporol, tinosporidine, sitosterol, cordifol, heptacosanol, octacosonal, tinosporide, columbin, chasmanthin, palmarin, palmatosides C and F, amritosides, cordioside, tinosponone, berberine, ecdysterone, makisterone A, 20 ?-hydroxyecdysone, nonacosan-15-one, ?-sitosterol, magnoflorine, tembetarine, syringine, glucan polysaccharide, syringine apiosylglycoside, isocolumbin, palmatine, tetrahydropalmaitine, jatrorrhizine. -http://www.iloveindia.com/indian-herbs/tinospora-cordifolia.htmlThe aqueous ext ract of T. cordi fol ia e x e r t e d a significant anti-inflammatory effect on cotton pellet granuloma and formalin induced arthritis models. Its effect was comparable with Indomethacin and its mode of action appeared to resemble that of a nonsteroidal anti-inflammatory agent. The dried stem of T. cordifolia produced significant anti-inflammatory effect in both acute and subacute models of inflammation. T . cordifolia was found to be more effective thanacetylsalicylic acid in acute inflammation. But insubacute inflammation, the drug was inferior to phenylbutazone 90. In a clinical evaluation, a compoundpreparation 'Rumalaya' containing T. cordifolia wasreported to significantly reduce the pain in patientssuffering from rheumatoid arthritis1 -CHEMISTRY AND MEDICINAL PROPERTIES OF TINOSPORA CORDIFOLIA (GUDUCHI) (http://medind.nic.in/ibi/t03/i2/ibit03i2p83.pdf) T. cordifolia is mentioned to treat vatarakta (gouty arthritis) and daha (burning sensation) in various Ayurvedic texts [Table 2]. It is traditionally used in compound formulations for the treatment of rheumatoid arthritis. [43] The alcoholic extract of T. cordifolia has been found to exert anti-inflammatory actions in models of acute and subacute inflammation. [44] The water extract of the stem of neem-giloe [The T. cordifoliathat grow on Azadirachta indica (neem)] significantly inhibited acute inflammatory response evoked by carrageenin in a dose of 50 mg/100 g given orally and intraperitoneally. A significant inhibition of primary and secondary phases of inflammation was observed in a model of adjuvant-induced arthritis. It also significantly inhibited antibody formation by

typhoid "H" antigen. A mild analgesic effect of its own as well as potentiation of morphine analgesia has been reported. [45] In another study aqueous extract of T. cordifolia showed a significat antiinflammatory effect in the cotton pellet granuloma and formalin induced arthritis model, it's effect was comparable with indomethacin and its mode of action appeared to resemble that of nonsteroidal antiinflamatory ageant. The dried stem of T. cordifolia produced significant anti-inflammatory effect in both acute and subacute models of inflammation. T. cordifolia was found to be more effective than acetylsalicylic acid in acute inflammation, although in subacute inflammation, the drug was inferior to phenylbutazone. [46] The aqueous extract of stem was reported to exert a significant anti-inflammatory effect in both cotton pellet-induced granuloma (1, 250 and 500 mg/kg given orally) and formalin-induced arthritis (1 mg/kg given orally) rat models. [47],[48] http://www.ijaronline.com/article.asp?issn=09747788;year=2010;volume=1;issue=2;spage=112;epage=121;aulast=Upadhyay-

Experimemts of antpyretic effect bay table lng akong nakitan Antipyretic Yeast induced Hexane, Dose effect pyrexia CHCl3/ 150 (Himalayan Water Rabbits) Soluble Fraction (Ethanolic; Stem) yeast induced Ethanolic pyrexia (Whole 50 (Albino Plant) rats)

Result 0.38-0.60oC Temperature decrease

Remarks Antipyretic effect

0.3-2 0C Temperatu re reduction

Antipyretic effect