Professional Documents
Culture Documents
Glycofilm - Solabia USA - 2011
Glycofilm - Solabia USA - 2011
BIOTECHNOLOGICAL POLYSACCHARIDE
BY SOLABIA
www.solabia.com
Aging is not always inevitable... Although we cant stop intrinsic aging, which is genetically programmed, extrinsic aging can be delayed and we can, maybe even should, fight against it. Extrinsic aging is also known as photo-induced aging, meaning it is induced by the suns rays, in particular ultra-violet. However, this name often makes us forget that it can be induced by other environmental factors, in particular pollution. While the harmful effects of pollution on our health were discovered several years ago, the role they play in the premature appearance of wrinkles and pigment spots has only lately come to light.
Airbone particle exposure and extrinsic skin aging. A.Vierkotter, T.Schikowski and al. Journal of Investigative Dermatology (2010) 130, 2719-2726
SUN
UVA and UVB rays are responsible for many harmful effects on the skin: damage to cell membranes, irreversible changes in the genetic make-up of the cells and the structure of proteins (which become inactive), weakening of the skins immune surveillance mechanism In the epidermis, after exposure to the sun, the keratinocytes stop dividing and start to mature, leading to a thickening of the epidermis, a natural protective phenomenon. However prolonged and repeated exposure throughout a persons life can disturb maturation and scaling of the keratinocytes and disorder the melanocytes, leading to premature formation of pigment spots. When the skin is sunburnt, the inflammatory process takes place very quickly, and subsequently tissue lesions appear in the epidermis, leading to the appearance of Sun Burn Cells (keratinocytes with an abnormal morphology likely to lead to cell death and elimination by accelerated scaling). Although one incidence of sun burn may not have much consequence, an accumulation of incidents will in time damage the natural defence processes and accelerate extrinsic aging: premature cell death, accumulation of Sun Burn Cells, and chronic inflammation, which will in turn damage the components of the dermis... Here again, beyond biological activity (inhibition of inflammatory phenomena, protection of collagen etc.), it is also possible to physically protect the skin against UV by using filters, anti-free radical agents and a protective cosmetic shield.
46 38 30
IN
THE STUDY CONDITIONS, THE CRE AM CONT AINING WELL PROTECTIVE EFFECT AG AINS T POLLUTION. VS PLACE BO, THE SKIN IS MORE PROTECTED BY CONT AINING
GLYCOFILM
PRESENTS A
GLYCOFILM AND MORE PROTECTED G L Y C O F I L M . AS A PROTECTIVE SHIELD GLYCOFILM OFFERS A DOSE-DEPENDENT EFFICACY A G A I N S T P O L L U T I O N , A V O I D E D T H E E M B E D D E D O F C A R B O N P AR T I C L E S I N T H E S K I N AND SO ON ITS CONSEQUENCE ON EXTRINSIC AGING.
1 % G L Y C O F I L M ,
BY
30 % W I T H T H E C R E A M 38 % W I T H T H E C R E A M C O N T A I N I N G 3 % B Y 46 % W I T H T H E C R E A M C O N T A I N I N G 5 %
On heavy metals
In vitro study on reconstructed epidermis / Topical application of Glycofilm at 5% vs Control (NaCl at 0,9%) / Incubation / Washing and treatment by a solution without or with CdCl2 (1mM, 2 mM, 5mM) / Evaluation of the epidermal cells viability by the MTT test. Concentration of cadmium (mM) Mean cellular viability (%) 0 100 CONTROL 1 2 99 77 5 48 5% GLYCOFILM 0 100 1 98 2 89 5 75
Protective effect of Glycofilm on cell viability following cadmium aggression THESE TEST CONDITIONS, GLYCOFILM EXHIBITS A PROTECTIVE EFFECT AG AINST TOXIC C ADMIUM CONCENTR ATIONS (IMPROVEMENT OF ME AN CELLUL AR V I A B I L I T Y V S C O N T R O L ) F O L L O W I N G T O P I C A L AP P L I C A T I O N . T H I S P R O T E C T I V E EFFECT CAN BE ATTRIBUTED TO THE REDUCED PENETRATION OF C ADMIUM IN THE EPIDERMIS SINCE THE C ADMIUM IS TRAPPED BY THE FILM FORMED BY THE POLYS ACCHARIDE ON THE SURFACE OF THE EPIDERMIS.
In brief
GLYCOFILM ACTS AS AN ANTI-AGING SHIELD BY PROTECTING THE SKIN FROM THE CONSEQUENCES POLLUTION, SUCH AS: - EMBEDDING OF CARBON PARTICLES IN THE SKIN, RESPONSIBLE FOR INCREASED FORMATION
WRINKLES AND PIGMENT SPOTS - INTOXICATION OF CELLS WITH HEAVY METALS, RESPONSIBLE FOR KILLING OFF CELLS OF OF
On inflammatory reactions
GLYCOFILM ALLOWS A IL1- R E L E A S E I N D U C E D - 53 %, A L L O W I N G T O CH AIN RE ACTION.
SIGNIFICANT INHIBITION OF BY UV, VS MODUL ATE
CONTROL:
I N F L AM M A T I O N
INDUCED
15,3 15,8 12,4 10,8 12,9 13,4 11,7 11,2 13,3 Control 3% Glycofilm 5% Glycofilm
G L Y C O F I L M A L O N E A L L O W S T O E N H A N C E T H E SPF B Y A R O U N D 1 P O I N T THE COMBIN ATION OF GLYCOFILM WITH INGREDIENTS REINFORCING ITS E F F E C T A L L O W S T O E N H A N C E T H E SPF B E T W E E N 2 A N D 3 P O I N T S
M ATRIX
In brief
GLYCOFILM ACTS AS AN ANTI-AGING SHIELD BY PROTECTING THE SKIN FROM THE CONSEQUENCES OF THE SUN, SUCH AS: - DAMAGE TO CELL MEMBRANES, RESPONSIBLE FOR ACCELERATING PREMATURE CELL DEATH - CHRONIC INFLAMMATORY REACTIONS, RESPONSIBLE FOR EXHAUSTING THE CELL DEFENCE
MECHANISMS AND DAMAGING THE COMPONENTS OF THE DERMIS - THE FORMATION OF SUN BURN CELLS WHICH CAUSE PREMATURE CELL DEATH AND MAY ACCUMULATE IF THEIR ELIMINATION PROCESS IS BLOCKED
CONCLUSION
Preventive and/or protective action is essential to combat aging, as in many cases it can minimise the consequences of external stresses on the skin (UV and pollution) and therefore slow down the extrinsic aging process, reducing the need for action by the skin's defence mechanisms, which if used too often will weaken over the years. Due to its capacity to form a shield on the skins surface, Glycofilm meets this need for protection. Due to its second skin effect, it gives invisible, yet effective protection!