DRUG STUDY Name of Patient: Age: Sex:

Date Classifica tion Amebicides and antiprotozo als Gener ic Name M E T R O N I D A Z O L E H Y D R O C H L O R I D E Brand Name F L A G Y L Mechanism of Action A direct acting trichomonacid e and amebicide that work at both intestinal and extraintestinal sites. Its thought to enter the cells of microorganis ms that contain nitroreductase . Unstable compounds are then formed that bind to DNA and inhibit synthesis, causing cell wall death.

Dx: Attending Physician: Ward:

Indication and Contraindication INDICATION: Intestinal amebiasis, refractory trichomoniasis, bacterial infection, bacterial vaginosis, and to prevent post partum infection in contaminated colorectal surgery CONTRAINDICATION: Contraindicated in patients hypersensitive to drug and other nitroimidazole derivatives. Use cautiously in patients with history of blood dyscasia or CNS disorder and in those with retinal or visual changes. Use cautiously in patient with hepatic disease. Actual Dose 125/5ml 1tsp 3 times a day Side Effects

Date started:

Nursing Responsibilities Observe 10Rs in giving medication Observe patient with edema, especially if receiving corticosteroids; it may cause sodium retention. Record number and character of stools when drug is used to treat amebiasis. Instruct patient in proper hygiene Tell patient he may experience a metallic taste and have dark or redbrown urine. Tell patient to report symptoms or candidal overgrowth. Tell patient to report any neurological symptoms such as seizures and peripheral neuropathy

Signat ure Studen t

Signatu re CI

GI effects, hypersensitivity reactions, peripheral sensory neuropathy, headaches, convulsion, dizziness, ataxia, psychotic disorders including confusion, hallucinations, transient visual disturbances. Very rarely, hematological effects, abnormal liver function tests, cholestatic hepatitis

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