CLINICAL SIGNIFICANCE HEMOGLOBIN Increased levels: Congenital heart disease Polycythemia vera COPD CHF High altitude Severe

Severe Burns Dehydration Hemoconcentration Decreased levels: Anemia Severe hemorrhage Hodgkins disease Hemoglobinopathies CA Hemolysis Lymphoma Sarcoidosis Kidney disease Chronic hemorrhage SLE HEMATOCRIT Increased levels: Decreased levels: Congenital Heart Disease Anemia Polycythemia vera Hyperthyroidism Severe dehydration Cirrhosis Shock Hemolytic reaction Erythrocytosis Hemorrhage Severe diarrhea Bone marrow failure Eclampsia Hodgkins disease Trauma Organ failure WBC Increased levels: Decreased levels: Leukocytosis Leucopenia Leukemic neoplasia Drug toxicity Infection Bone marrow failure Trauma Overwhelming infections Stress Dietary deficiency Tissue necrosis Autoimmune disease Inflammation Bone marrow infiltration RBC Increased levels: Decreased levels: Polycythemia vera Anemia Cardiac or Pulmonary disorders Hemorrhage Dehydration Oligocythemia Acute poisoning PLATELET Increased levels: Decreased levels: Thrombocytosis Thrombocytopenia Malignant disorders Hypersplenism Polycythemia vera Hemorrhage Leukemia Liver disease

 Kidney diasease Pernicious & hemolytic anemia CA chemotherapy NEUTROPHILS Increased levels: Decreased levels: Stress Aplastic anemia Acute suppurative infection Dietary deficiency Myelocytic leukemia Overwhelming bacterial infection Trauma Viral infection Cushings syndrome Radiation therapy Inflammatory disorders Addisons disease LYMPHOCYTES Increased levels: Decresed levels: Chronic bacterial infection Leukemia Viral infection Sepsis Lymphocytic leukemia Immunodeficiency Multiple myeloma SLE Infectious mononucleosis Later stage of HIV Infectious hepatitis Drug therapy (adrenocorticosteroids) Radiation therapy MONOCYTES Increased levels: Decreased levels: Chronic Inflammatory disorders Drug therapy (prednisone) Viral infections TB Chronic Ulcerative Colitis parasites EOSINOPHILS Increased levels: Decreased levels: Parasitic infection Increased adrenocorticostreroid production Allergic reactions Eczema Leukemia Autoimmune disease BASOPHILS Increased levels: Decreased levels: Myeloproliferative disease Acute allergic reaction Myelofibrosis Hyperthyroidism Leukemia Stress ESR Increased levels: Decreased levels: Toxemia CHF Syphilis Sickle cell anemia Nephritis Hypofibrinogenemia Multiple myeloma Polycythemia vera Bacterial infections Infectious mononucleosis Pneumonia Degenerative arthritis

Postplenectomy Rheumatoid arthritis Cirrhosis ; Trauma

Rheumatoid arthritis Rheumatic fever Acute MI Hyperfibrinogenemia

Angina pectoris