Q.1. Depot preparations of the Gonadotropin Releasing Hormone (GnRH) analogues (e.g.

Lupron Leuprolide) are used in the treatment of endometriosis and precocious puberty because ONE of the following: a. b. c. d. They simulate the natural pulsatile discharge of GnRH They are given intravenously They are more useful in the diagnosis of GnRH deficiency They inhibit FSH and LH secretion

Q.2. Which one of the following is a complication of gonadotropins? a. b. c. d. Amenorrhea Ovarian hyper stimulation Galactorrhoea Cryptorchidism

Q.3. Which one of the following is used for the treatment of myxoedema coma? a. b. c. d. Liothyronine Lithium Propylthiouracil (PTU) Protirelin

Q.4. Which one of the following is not a use of propranolol? a. b. c. d. Hypertension Angina Peripheral vascular disease Hyperthyroidism

Q.5. One of the following statements is not true for acyclovir. a. b. c. d. It acts by inhibiting viral DNA synthesis It is effective against hepatitis B virus It is effective as an ointment for ocular herpes simplex keratitis Is effective against varicella- zoster virus

Q.6. Which one of the following statements is not true for amebiasis? a. b. c. d. Metronidazole is of first choice for intestinal and tissue amebiasis Dehydroemetine may cause cardiotoxicity Diloxanide is useful in eradication the cystic forms from the bowel lumen Paromomycin is the drug of choice for hepatic amebiasis

Q.7. Which one of the following antifungal is used to treat cryptococcal fungal infection of meninges? a. b. c. d. Clotrimazole Miconazole Nystatin Ketoconazole

Q.8. One of the following is not a use of thiazide diuretics? a. b. c. d. Hypertension Edema of congestive heart failure Edema of cirrhosis Glaucoma

Q. 9. Which one of the following drugs is used only for hypertensive emergencies? a. b. c. d. Atenolol Sodium nitroprusside Amlodipine Losartan

Q.10. One of the following is not used in the treatment of chronic heart failure (CHF)? a. b. c. d. Captopril Frusemide Digoxin Heparin

Q.11. One of the following statements is not true for nitrites/nitrates? a. b. c. d. They reduce preload and after load They cause coronary dilatation They decrease heart rate They may be used in all types of angina

Q.12. Find the mismatch for the drug and its adverse effect: a. b. c. d. Quinidine-----------------------Cinchonism Disopyramide------------------Anticholinergic effect Amiodarone--------------------Hypothyroidism and hyperthyroidism Adenosine----------------------Torsades de pointes

Q.13. Which one of the following drug group/drug is primarily bactericidal: a. b. c. d. Sulphonamides Tetracyclines Aminoglycosides Chloramphenicol

Q.14. One of the following statements is true for aminoglycosides. a. b. c. d. They are in general inactivated by metabolism in the liver They are in general active against anaerobic gram-negative organisms They can cause nephrotoxicity They are not used topically

Q.15. Tetracyclines can cause all of the following except: a. b. c. d. Liver damage, especially in pregnancy Not effective against Mycoplasma pneuminiae and Clamydia trachomatus Photosensitization Opportunistic infection with yeasts and moulds

Q.16. The use of chloramphenicol may result in (select one correct): a. b. c. d. Bone marrow stimulation Photo toxicity Aplastic anemia Staining of teeth

Q.17. Ampicillin and amoxicillin are in the same group of penicillins. Which one of the following statements is best characterized by amoxicillin? a. b. c. d. It has better oral absorption than does ampicillin It can be used in penicillinase-producing organisms It does not cause hyper sensitivity reactions It is effective against Pseudomonas

Q.18. Which one of the following is the most effective drug for immunosuppression of rejection of the allograft kidney? a. b. c. d. Azathioprine Cyclosporine Cyclophosphamide Vincristine

Q.19. Cardiotoxicity limits the clinical usefulness of which one of the following antitumor antibiotics? a. b. c. d. Dactinomycin Doxorubicin Bleomycin Cisplatin

Q.20. Binding to the enzyme dihydrofolate reductase (DHFR) is the mechanism of action for: a. b. c. d. Procarbazine Paclitaxel Methotrexate Ifosfamide

Q.21. Which ONE of the following is UNTRUE for vitamin Ds? a. b. c. d. They promote calcium and phosphate absorption from intestine They promote calcium deposition in bones in rickets patients Dietary Vit D is converted to dihydroxy Vit D (Calcitriol) in the liver Calcitriol is useful in chronic renal failure

Q. 22. Which one of the following is not a first line Anti-TB drug? a. b. c. d. Ethionamide Isoniazid Pyrazinamide Rifampin

Q.23. Find the mismatch in the following pairs (drug and its use): a. b. c. d. Oxamniquine-----------------------------Schistosoma mansoni Niclosalosamide--------------------------Ascaris lumbricoides Diethylcarbamazine ---------------------All schistosomal species Metrifonate--------------------------------Schistosoma hematobium

Q. 24. Which one of the following is untrue regarding chloroquine? a. b. c. d. It is effective against secondary liver phase (hynozoites) of P. vivax & P. ovale It prevents relapse with P. vivax & P. ovale infection Rapid IV administration can cause hypotension It has anti-inflammatory action when used for long time

Q. 25. One of the following statements is NOT TRUE for aminoglycosides? a. b. c. d. They are well absorbed when administered orally They can be used in treatment of Gram negative septicemia They have narrow therapeutic window They may cause nephrotoxicity and ototoxicity

Q.26. Which one of the following is NOT TRUE for chloramphenicol? a. b. c. d. It can easily cross blood brain barrier It is ineffective against salmonella infections It may cause bone marrow depression It may produce gray baby syndrome in a new born babies.

Q.27. All of the following antibiotics are effective in treatment of Hemophilus influenzae infections EXCEPT: a. b. c. d. Azithromycin Doxycycline Amoxacillin Cephalexin

Q.28. Which one of the following statements about the combination of trimethoprim plus sulfamethoxazole (Co-trimoxazole) is FALSE? a. b. c. d. This combination is effective in the treatment of pneumonia due to Pneumocystis carinii The drugs produce a sequential blockade of folic acid synthesis Fever and pancytopenia occur frequently when these drugs are used in AIDS patients It is ineffective in treatment of complicated upper urinary tract infection

Q.29. Which ONE of the following statements about imipenem is most accurate? a. b. c. d. The drug has a broad spectrum of antibacterial action It is used in fixed combination with sulbactam Imipenem is highly susceptible to beta-lactamases produced by enterobacter species Its use in combination with cilastatin may produce nephrotoxicity

Q.30. Following are immune suppressant agents : a. b. c. d. Cyclosporine Prednisone Leflunomide Interferons

Q.31. Following are side effects of using high dose testosterone EXCEPT: a. b. c. d. Virilization of females Liver injury Aggression Diabetes mellitus

Q.32. Following are true about amiodarone EXCEPT: a. b. c. d. Its t is about 90 min after multiple dosing It has a noncompetitive beta-blocking activity It can be used in treatment of chronic ventricular arrhythmiasI t can produce corneal microdeposits