Biochemistry 3G03 Biochemistry of Macromolecules Term I (2011-2012) Course Outline

Instructor:
Dr. Daniel Yang. Office: HSC-4H31a, yang@mcmaster.ca

Teaching Assistants:
Mulder, David, Woloshansky, Tanya, mulderdt@mcmaster.ca wolosht@mcmaster.ca

Introduction: Chemical and conformational properties of proteins and relationships to their function including regulation
of enzyme activity. Chemical and physical structure of DNA and RNA relevant to biological function.

Evaluation: It will be based on five tests and a final examination (all multiple choices). Students are responsible for
materials covered in the textbook. The final grade will be calculated using the following two schemes and the higher of the two will be used: Scheme A - Five tests only (20% each); Scheme B - The best four of the five tests (15% each) + final examination (40%). No make-up tests will be offered. If you miss a test (with or without filing MSAF), the test will receive a grade of ZERO and Scheme B will automatically be chosen. Percentage grade will be converted to a final letter grade (see Table below). % Letter % Letter % Letter % 100-90 A+ 79 - 77 B+ 69 67 C+ 59-57 89 85 A 76 - 73 B 66 63 C 56-53 84 80 A72 - 70 B60-62 C52-50 All percentage grades within 0.5% of the next letter grade will be reviewed. Letter D+ D D% 49-0 Letter F

Questions: Students are encouraged to ask questions in class and use Learnlink for discussion. Textbook: Fundamentals of Biochemistry, 3rd edition. D.Voet, J.G.Voet, and C.W.Pratt. Wiley & Sons Inc. 2008. Academic ethics: Students are asked to reread two documents provided on registration, the Senate Statement on
Academic Ethics and the Senate Resolutions on Academic Dishonesty. Students should be sure that they understand the expectations the University has of its scholars, and the possible consequences when these expectations are not met.

Academic dishonesty consists of misrepresentation by deception or by other fraudulent means and can result in serious
consequences, e.g. the grade of zero on an assignment, loss of credit with a notation on the transcript (notation reads: Grade of F assigned for academic dishonesty), and/or suspension or expulsion from the university. It is your responsibility to understand what constitutes academic dishonesty. For information on the various kinds of academic dishonesty please refer to the Academic Integrity Policy, specifically Appendix 3, located at: http://www.mcmaster.ca/univsec/policy/AcademicIntegrity.pdf

Additional notes: The instructor and university reserve the right to modify elements of the course during the term. The
university may change the dates and deadlines for any or all courses in extreme circumstances. If either type of modification becomes necessary, reasonable notice and communication with the students will be given with explanation and the opportunity to comment on changes. It is the responsibility of the student to check their McMaster email and course websites weekly during the term and to note any changes.

Schedule of Lectures, Office hours & Tests. Place: BSB/147

Lectures: Tues, Wed, Fri (9:30-10:20 am); Office hours: Tues (10:30-11:20 am)
Lecture Date 1 Sep-09 2 Sep-13 3 Sep-14 4 Sep-16 5 Sep-20 6 Sep-21 7 Sep-23 8 Sep-27 9 Sep-28 10 Sep-30 11 Oct-04 12 Oct-05 13 Oct-07 14 Oct-11 15 Oct-12 16 Oct-14 17 Oct-18 18 Oct-19 19 Oct-21 20 Oct-25 21 Oct-26 22 Oct-28 23 Nov-01 24 Nov-02 25 Nov-04 26 Nov-08 27 Nov-09 28 Nov-11 29 Nov-15 30 Nov-16 31 Nov-18 32 Nov-22 33 Nov-23 34 Nov-25 35 Nov-29 36 Nov-30 37 Dec-02 Time Fri: 9:30-10:20 am Tue: 9:30-10:30 am Wed: 9:30-10:30 am Fri: 9:30-10:20 am Tue: 9:30-10:30 am Wed: 9:30-10:30 am Fri: 9:30-10:20 am Tue: 9:30-10:30 am Wed: 9:30-10:30 am Fri: 9:30-10:20 am Tue: 9:30-10:30 am Wed: 9:30-10:30 am Fri: 9:30-10:20 am Tue: 9:30-10:30 am Wed: 9:30-10:30 am Fri: 9:30-10:20 am Tue: 9:30-10:30 am Wed: 9:30-10:30 am Fri: 9:30-10:20 am Tue: 9:30-10:30 am Wed: 9:30-10:30 am Fri: 9:30-10:20 am Tue: 9:30-10:30 am Wed: 9:30-10:30 am Fri: 9:30-10:20 am Tue: 9:30-10:30 am Wed: 9:30-10:30 am Fri: 9:30-10:20 am Tue: 9:30-10:30 am Wed: 9:30-10:30 am Fri: 9:30-10:20 am Tue: 9:30-10:30 am Wed: 9:30-10:30 am Fri: 9:30-10:20 am Tue: 9:30-10:30 am Wed: 9:30-10:30 am Fri: 9:30-10:20 am To be announced Topics remarks Organization Introduction, Chemistry of Life Thermodynamics, Water, Acid-Base Acid-Base, Buffer Nucleotides and Nucleic Acids Genetic Information Test 1 (Chapters 1 & 2) Amino Acids Amino Acids Proteins: Primary Structure Proteins: Primary Structure Proteins: 3-D Structure Test 2 (+ Chapters 3,4,5) Proteins: 3-D Structure Proteins: 3-D Structure Protein Functions Protein Functions Protein Functions Enzymatic Catalysis Enzymatic Catalysis Enzyme Kinetics etc. Test 3 ( + Chapters 6,7) Enzyme Kinetics etc. Nucleic Acid Structure Nucleic Acid Structure DNA Replication, Repair & Recombination DNA Replication, Repair & Recombination Test 4 ( + Chapters 11,12) DNA Replication, Repair & Recombination Transcription & RNA processing Transcription & RNA processing Transcription & RNA processing Protein Synthesis Test 5 ( + Ch 24,25,26) Protein Synthesis Protein Synthesis Review Final Exam Chapter 1 1, 2 2 3 3 4 4 5 5 6 6 6 7 7 7 11 11 12 12 24 24 25 25 25 26 26 26 27 27 27

Notes.

List of sections to be omitted and location of Tutorials will be posted on Learnlink. Tutorials are scheduled for Mon, Tue, Wed and Thur evenings (4:00-5:30 pm) before each Test.