Inductively Coupled Plasma Mass Spectrometry (ICP-MS)

Lauren Huang Period 4

Overview
Purpose History Procedures
Steps Video

Applications Questions

Figure 1. Inside of an ICP-MS machine.

http://www.wcaslab.com/tech/tbicpms.htm

Purpose
To determine the concentration of trace elements in a sample with high sensitivity.

Figure 2. Analyzable elements.

http://www.perkinelmer.com/PDFs/Downloads/tch_icpmsthirtyminuteguide.pdf

History
Mass spectrometry Atomic absorption spectroscopy (AAS) Inductively coupled plasma optical emission spectrometry (ICP-OES) Interference

Figure 3. Absorption and Emission Spectra.

http://socphysics.blogspot.com/2010/08/hydrogenemission-and-absorption.html

Steps: Introduction of the Sample

Nebulizer: Liquid to aerosol Laser ablation: Solid to vapor

Figure 4. Laser ablation.

http://www.appliedspectra.com/technology/LIBS.html

Steps: Atomization & Ionization

Argon plasma (6,000 - 10,000oC) Sample to atoms (atomization) Atoms to ions (ionization)

Figure 5. Argon plasma.

http://www.cee.vt.edu/ewr/environmental/teach/smprimer/icpms/icpms.htm

Steps: Separation
Voltage applied to rods Ions removed by mass-to-charge ratio

Figure 6. Removal of ions.

http://www.cee.vt.edu/ewr/environmental/teach/smprimer/icpms/icpms.htm

Steps: Detection
Dynode Signal amplification

Figure 7. Electron multiplier.

http://www.cee.vt.edu/ewr/environmental/teach/smprimer/icpms/icpms.htm

Procedures
3. Separation 2. Atomization/Ionization - +- + -+ + + 4. Detection and Analysis

1. Introduction of thehttp://www.chem.iastate.edu/faculty/Robert_Houk/research sample

Video of Procedures
http://www.youtube.com/watch?v=MQqtV2o iC6U&t=1m38s

Applications
Soil/water analysis Toxicology Isotopic ratios Radiometric dating

Figure 8. ICP-MS Machine in Use.

http://departments.colgate.edu/geology/instruments/icp.htm

Questions?

Figure 9. Inside of an ICP-MS machine.

http://www.wcaslab.com/tech/tbicpms.htm

Works Cited
(2010, August 14). Hydrogen Emission and Absorption Spectrum. Message posted to http://socphysics.blogspot.com/2010/08/hydrogen-emission-andabsorption.html. (2010, July). Inductively Coupled Plasma Mass Spectrometer Lab. Retrieved November 13, 2011, from Colgate University, Colgate Geology Web site: http://departments.colgate.edu/geology/instruments/icp.htm Applied Spectra, Inc. (2011). What is LIBS? Retrieved November 13, 2011, from http://www.appliedspectra.com/technology/LIBS.html. Houk, R. S. R. S. Houk. Retrieved November 13, 2011, from Iowa State University, Department of Chemistry Web site: http://www.chem.iastate.edu/faculty/Robert_Houk/research. Hunt, J. (2008, September 6). Celebrating 25 Years of Inductively Coupled Plasma-Mass Spectrometry. American Laboratory. PerkinElmer. (2011). The 30-Minute Guide to ICP-MS. Retrieved November 13, 2011, from http://www.perkinelmer.com/PDFs/Downloads/tch_icpms thirtyminuteguide.pdf. West Coast Analytical Service. Metals Analysis by ICPMS. Retrieved November 13, 2011, from http://www.wcaslab.com/tech/tbicpms.htm. Worley, J., & Kvech, S. ICP-MS. Retrieved November 13, 2011, from http://www.cee.vt.edu/ewr/environmental/teach/smprimer/icpms/icpms.htm.