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Praju&Avanti
Technoxtreme-09
In
BIOPOLYMERS IN TEXTILES
INTRODUCTION
During the last two decades many significant advances have been made in development of biocompatible materials for biomedical applications and industrial applications also. In biomedical field the aim is to develop and characterize artificial materials for use in human body to measure, restore and improve physiological function and enhance survival and quality of life.
CLASSIFICATION OF BIOPOLYMER
Biopolymers can be derived from microbial systems, extracted from higher organisms such as plants, or synthesized chemically from basic biological building. Biopolymers are being developed for use as medical materials, packaging, cosmetics, food additives, clothing fabrics, water treatment chemicals, industrial plastics, absorbents, biosensors, and even data storage elements.
Biopolymer properties
o Non-toxic (biosafe): Non- pyrogenic, Nonhemolytic, Chronically, non- inflammative, o Effective: Functionality, Performance, Durability, etc o Sterilizable: Ethylene oxide, c-Irradiation, Electron beams, Autoclave, Dry heating,etc. o Biocompatible: Interfacially, Mechanically, and Biologically
Collagen:
Collagen is well established as a safe and effective biomaterial and was one of the. Rest to be used in medical products. It combines the properties of high tensile strength, biocompatibility and absorbability in living tissue. Before the era of synthetic polymers, collagen sutures were used as a standard material in surgical procedures, a practice that can be traced back to the Ancient Egyptians.
Collarx technology
Collarx is a localized drug delivery system based upon a type-1 collagen matrix derived from bovine or equine Achilles tendon. Products may be formatted either as a lyophilized porous sponge or as a transparent/translucent sheet (or membrane) about 50 m in thickness (Figure 2 In vivo, drug is released by a combination of diffusion and natural enzymatic breakdown of the collagen matrix. This provides both rapid and prolonged release. The matrix itself is fully resorbed within one to seven weeks according to implant location .
Transparent Sheet
Collatamp G is an implantable type-I collagen sponge impregnated with 2.0 mg/cm2 of gentamicin sulfate. It is approved as a medicinal drug product in many European countries and is currently marketed under various brand names by Schering Plough Corporation. The product is indicated for the surgical treatment and post-surgical prevention of infection in bone and soft tissue and has been clinically proven to reduce rates of infection and substantially reduce the average duration of hospital stay. Pharmacokinetic studies have demonstrated that high local concentrations of gentamicin.
Collatamp G
CONCLUSION
Textile materials like biocompatible polymers continue to serve an important function in the development of a range of medical and surgical products. The introduction of new materials, the improvement in production techniques and fiber properties, and the use of more accurate and comprehensive testing have all had significant influence on advancing fibers for medical applications.