1.

Immune System
Robin Webb Corbett, PhD, RN,C East Carolina University School of Nursing

Primary & Secondary Lymphoid Organs

2.

3.

Lymph Node Structure

4.

Primary & Secondary Immunity

5.

Blood Types

6.

Lymphocyte Maturation

7.

T-Cell Production

8.
Table 6-4
CD No. 1 2 3 4 5 7 8 Early thymocytes Early thymocytes, receptor for sheep RBCs T cells, interacts with T cell receptor Th cells, adhesion molecule for class II HLA binding T cells Early thymocytes binding
CD, Cluster of differentiation; RBCs, red blood cells; Th, helper T; HLA, human leukocyte antigen; Tc, cytotoxic Ts, suppressor T.

CD Antigenic Markers of T Cell Development

Cell Type

Tc and Ts cells, adhesion molecule for class I HLA

T-Cell Development

9.

Cellular Interactions

10.

Antibody Production

11.

Antibody Function

12.

Table 6-7
Type

Cytokines
Source Main Functions

INTERLEUKINS (IL)
IL-1 ( and )

Predominantly macrophages

Cytokines

IL-2 (T cell growth factor [TCGF]) IL-3 (multiple colonystimulation factor [CSF]) IL-4 (B cell growth factor [BCGF]) IL-5

Predominantly helper T lymphocytes; NK cells

Immune response; inflammatory mediator; activates T cells; activates phagocytes; prostaglandin production; induces a fever T lymphocytes and NK cells; growth and T cells

T lymphocytes, mast cells, NK Hematopoietic growth factor cells for immature hematopoietic precursor cells, NK cells T lymphocytes, macrophages Growth factor T cells, activated B cells, and mast cells; macrophage-activating factor, IgE reactions Growth and proliferation of activated B cells, eosinophils, T cell production B cell stimulatory and differentiation factor; hematopoiesis, inflammatory response, fever Lymphoid cells Triggers chemotactic activity of neutrophils and lymphocytes T cell and mast cell growth factor; maturation of erythroid progenitors Proliferation of helper T cells; cytotoxic T cell differentiation; induces MHC antigen expression, cytokines

T lymphocytes, macrophages

IL-6

Monocytes, T and B lymphocytes, fibroblasts, endothelial cells Bone marrow, thymus Macrophages, monocytes, endothelial cells

IL-7 IL-8 (Monocytederived neutrophil chemotatic factor) IL-9 IL-10

Helper T cells Helper T cells

Macrophage Activation

13.

14.

B-Cell Activation T-Cell Antigen

15.

Primary & Secondary Immune Responses

16.

IgC Trophoblast

17.

Complement Cascade Activation

p. 203 fig 7-7

18.
1. Antigen appears T lymphocytes / B lymphocytes interact recognize it as foreignm Thymus lymph nodes release T lymph T cells attack antigen directly

Immune Response

2.

IMMUNE RESPONSE 5. Serum complement stimulates release of histamine -/\ capillary permeability promote vasodilation stimulate release of macrophages 6. Complement roughens antigens surface attracts macrophages and neutrophils- which engulf & attack the cell Lysosomes attach to cell and release enzyme hydrolasebreaks down cells protein and lipids Some IgG- remember

3.

B cells release -IgM- initial response then IgG- long term immunity have specific sites that attach to antigens 7. Change in Antibody shape complement cascade circulating proteins 8.

4.

19.

Mitral Stenosis -

20.

Glomeruli Injury

21.

Lupus Erthematosu s

22.

Fibromyalgia Theoretical Model

23.

Fibromyalgia Diagnostic Classification

24.

HIV Life Cycle

25.

HIV & Immune System

26.

Hypersensitivity Reaction

27.

Type I Hypersensi tivity

Type I Hypers ensitivi ty Reactio n

28.

Type II Hypersensitivi ty Reaction

29.

30.

Type III Hypersensitivity Reaction

31.

Type IV Hypersensitivity Reaction

Hypersensitivity Reactions
32.