Suplements

BUSINESS PLAN PRESENTATION

Drugs used on topical medications and cosmetics:

Amino benzoic Acid (PABA) used in sunscreen cosmetics Avobenzone (aka butyl methoxydibenzoylemethane, Parsol 1789) used in sunscreens Benzocaine Benzoyl Peroxide (used in acne medications and cosmetics) Benzyl Nicotinate Capsaicin Corticosteroids Diethanolamine p-methoxycinnamate (sunscreens) Dicxybenzone Esthylhexyl p-methoxycinnamate Ethyl Salicylate Glycol salicylate Hydrocortisone Hydrogen Peroxide Hydroquinone - pigment lightening agent Methyl nicotinate Methyl salicylate Octinoxate (formerly octyl methoxycinnamate) - sunscreen Oxybenzone Resorcinol Retinoids (tretinoin, Renova, Retin-A, Avita, Differin) Salicylic Acid Sulisobenzone Topical antihistamines Trichloroacetic acid Triclosan

Drugs Taken Oral or Inhaled:

Alcohol (ethanol, spirits) Aminophyllin Anabolic steroids Angiotensin-converting enzyme inhibitors (aka ACE inhibitors) Aspartame (NutraSweet) Aspirin Calcitonin Calcium channel blockers Cocaine Cortiscosteroids Corticotrophin-releasing hormone Ibuprofen Lovastatin (Mevacor) Marijuana Naproxen (Naprosyn) Niacin (aka Vitamin B3) Nicotine Nifedipine Nitrates (food related) Nitroglycerin Opioid narcotics (morphine, codeine, thebaine, methadone, Demerol, Darvon, Dolophine, Vicodin, Percodan, Dilaudid) Progesterone Simvastatin (Zocor) Sodium monoglutamate (food related) Theophylline Vancomycin Vasodilators Viagra

Drugs used in Cosmetics

2-bromo-2-nitropropane-1,3-diol Acetone Albumin (egg whites) Alcohol (volatile only: ethanol, ethyl alcohol, isopropyl alcohol, isopropanol, SD alcohol, alcohol denatured) Algae Alpha hydroxy acids and salts (including but not limited to: glycolic acid, lactic acid, citric acid, malic acid, tartaric acid, sodium glycolate, ammonium glycolate, sodium lactate, ammonium lactate) Ammonia Arachidonic acid Arnica oil Ascorbic Acid (vitamin C) Balsam Peru Barley Bay laurel oil Bayberry oil Bentonite Benzalkonium chloride Benzophenones Bergamot oil Bitter orange oil Black pepper oil Bromelain Caffeine Camphor oil CaCayenne Cetrimonium bromide psicum Chamomile oil Cinnamic aldehyde Cinnamon oil Clove oil Cocoa butter Coriander oil (from the seeds of Cilantro) Corn extract Cornstarch Diazolindinyl urea DMAE DMDM hydantoin Eucalyptus oil Fennel oil or extract Fir needle oil Fragrance (synthetic or natural) Gernaiol (found in palmarosa oil, geranium oil, jasmine oil, lavender oil, citronella oil, rose oil and many other essential oils used in aromatherapy and skin care products, shampoos and make up) Ginger Ginseng Granular exfoliants (including Loofah, oatmeal, peach kernels, walnut shells, salt, sand, pumice, diatomaceous earth, microdermabrasion crystals, jojoba beads, polyethylene beads) Grapefruit oil or extract Imidazolidinyl urea Iodine Lanolin Lecithin Lemon oil

Drugs used in Cosmetics II

Lemongrass oil Lime oil Mannan Menthol Mica Montmorilonite Mustard Myrrh Oil Nettle Niacin (vitamin B3) Nutmeg Oil Oak moss extract Oats Orange oil PABA (sunscreen) Papain (enzyme found in digestive remedies, skin exfoliating cosmetics) Papaya extract (found in many cosmetics) Peanut oil Pennyroyal Peppermint Phenol Phenoxyethanol Phosphatidylcholine Pine oil Propylene glycol Quarternium-15 Retinol (vitamin A) Rosemary oil Rue oil Saccharomyces (yeast) Saccharomyces lysate Sage essential oil Salicylic acid (BHA) Sandalwood oil Seaweed Sesame oil Sodium C14-16 Sodium laureth sulfate Sodium lauryl sulfate Soy protein Spearmint oil Stearic acid Stearalkonium chloride Sulfur Tangerin oil TEA-lauryl sulfate Tea tree oil (maleleuca) Thyme essential oil Tocopherol Tocopheryl nicotinate Turmeric oil Vanilla extract or oil Wintergreen Witch hazel (when in alcohol or propylene glycol) Ylang-ylang oil

Environmental Triggers:

Atmosphere: history of sun burns (impairs immune system), carbon monoxide/dioxide, Bacteria: history of acne Airborne: Proximity to heavy industrial complex, factories, mining, freeways, polluted water, dry cleaning facility Parasites: Demodex mites Inner atmosphere: household dust, sick-building syndrome, lead, radon, asbestos, house hold cleansers and sprays, insecticides, aromatherapies and room deodorizers

Corticosteroid mechanism

Anti-Inflamation

Prevent margination (leucocytes & monocytes adherent)

Inhibit Chemotaxis Vasoconstriction

Decreasing membran permeability

Inhibit releasing of toxic agent extravasation serum , swelling

Immunosupresant

Differentiation of limphoid cells

Lysis

of B lymphocytes

lymphocines activities Antimytotic

Inhibit

Supress cells proliferation

Decrease RNA transcription, DNA synthesis, DNA reparation Skin: keratinocytes, fibroblast collagen & fibril

In T-cells, activation of the T-cell receptor normally increases intracellular calcium, which acts via calmodulin to activate calcineurin. Calcineurin then dephosphorylates the transcription factor NF-AT (nuclear factor of activated T-cells), which moves to the nucleus of the T-cell and increases the activity of genes coding for IL-2 and related cytokines. Tacrolimus prevents the dephosphorylation of NF-AT.[8] In detail, Tacrolimus reduces peptidyl-prolyl isomerase activity by binding to the immunophilin FKBP12 (FK506 binding protein) creating a new complex. This FKBP12-FK506 complex interacts with and inhibits calcineurin thus inhibiting both Tlymphocyte signal transduction and IL-2 transcription