Molecular and Cellular Basis of Medicine

MCBM III (Element 6)

Course code: MMCM 31105 (Taught by Unit of Microbiology (6ABC) and Pathology (6D/7) Faculty of Medicine, AIMST) MCBM III/Element 6 Coordinator Dr. P. K. Rajesh. M.D. Microbiology DDP, Faculty of Medicine, AIMST

OVERVIEW of the ELEMENT

6A-Immunity =13 lectures 6B-Infection =25 lectures 6C-Control of Infectious disease =4 lectures 6D-Inflammation and repair =9 lectures 13 interactive review sessions 7 practical sessions of 3 hours each at the MDLs. 2 symposia (3 hours each)

YEAR I, TERM I and II

Contact Hours:
Lectures 51 hours

Interactive review sessions

Practical + symposia Total

13 hours
27 hours 91 hours

T/L Methodology
45
40 35 30 25 20 15 10 0
4 6

12

Practicals IRS Lectures

6
2

25

13
5
0
6A 6B 6C

3
1

9
6D

Areas covered in this element:

(6A) The ways in which the immune system is involved in clearing infectious material and how the immune response may actually be damaging to the host (hypersensitivity and autoimmunity). (6B) The biology of the groups of organisms that are capable of causing disease in man (bacteria, viruses, protozoa, helminthes and fungi) (6C) How organisms spread between individuals and how knowledge of the mechanisms is used to help prevent and treat infectious disease in the host population (6D) The pathological processes of inflammation, cell injuryits causes, mechanisms and the pathological aspects of wound healing.

Overall course Objectives:

At the end of this course the student should be able to explain the role of inflammation in activating components of the immune system. describe the distinct components of the humoral and cell mediated immune response discuss the disorders of immune deficiency and overactivity. illustrate the structure and discuss the physiology of microorganisms, involved in common infective processes. compare and contrast between the modes of transmission of microorganisms.

Course Objectives continued

At the end of this course the student should be able to comprehend the principles underlying methods of sterilization, disinfection and aseptic procedures. explain the mechanisms of action of major antimicrobial agents and the acquisition of resistance to antimicrobial agents. describe the pathological processes of inflammation, cell injury and repair. stain, observe and interpret a Gram smear. isolate bacterial colonies on pure culture. Element 6 ABC Objectives and learning outcomes-B18.ppt 6D and Element 7 outcomes will be issued by Dr.Bharathi

Important
Importance of Specific Learning Outcomes

Components of SLO
The written description of
A task (ACTIVITY+CONTENT+CONDITION), accompanied by A criterion (quality, accuracy &/or speed) denoting an acceptable level of proficiency, which the learner should be able to do at the end of a learning period which they could not do beforehand

Elements of Learning Outcomes

(Mager, 1975)

The Activity - The skill or behavior What

the learner will do (Action Verb)

The Content - what the learner will be able

to know, do, have an opinion about in relation to the activity. The criteria - the limits or range of an acceptable response, i.e., how well does the learner have to perform? Eg-..diagnose bone age from a given set of xrays with an error of 1 year.

SLO COMPONENTS
At the end of the training, the athlete should be able to RUN (ACTIVITY) 100 metres (CONTENT) WITHIN 10 SECONDS (CRITERIA) USING HIS OWN LOWER LIMBS (CONDITION)

SLO COMPONENTS
At the end of this session the students will be able to measure blood pressure correctly with an error of + or 5 mm on a supine resting patient/mannequin Activity-Do what? Measure Content-Measure what? BP Criteria-How well? Within +/ 5mm difference Condition-Resources provided or denied eg.Manual Sphygmomanometer/Mannequin

Microbiology-Guinea worm-Medicine

Dr.P.K.Rajesh.M.D.

How do we get cold (flu)?

Dr.P.K.Rajesh.M.D.

Modes of transmission
DIRECT Direct contact Droplet transmission Contact with soil Inoculation skin/mucosa Transplacental-mother to child INDIRECT Vehicle borne-blood, milk Vector borne-insects Air borne (nuclei) Fomite-objects Unclean hands and fingers

Assignment last date Sep 17 2012

Dr.P.K.Rajesh.M.D.

Dr.P.K.Rajesh.M.D.

Total marks in MCBM III

Continuous Assessment Marks (30) + MCBM III Final Written Exam Marks (70) = Total (maximum marks): 100

Continuous Assessment
YEAR I, TERM I FIRST CA (6A(1), D(1)) -THEORY (Objective/Subjective) SECOND CA (6A(2),6D(2)) -THEORY (Objective/Subjective) YEAR I, TERM II THIRD CA (6B(1),7(1)) -THEORY (Objective/Subjective) FOURTH CA (6B(2)C, 7 (2)) -THEORY (Objective/Subjective) - PRACTICAL (Marks allotted to stand alone multidisciplinary OSPE paper)

ALL CAs Micro 60:Path 40

For eg CA 1-6A/6D (1) 6A-(10 MCQ=10 marks/4 SAQ=20 marks)=30 marks 6D-(10 MCQ=10 marks/2 SAQ=10 marks)=20 marks For eg CA 3-6B/7 (1) 6B-(10 MCQ=10 marks/4 SAQ=20 marks)=30 marks E7-(10 MCQ=10 marks/2 SAQ=10 marks)=20 marks

How is the continuous assessment (CA) score (30 marks) in MCBM III derived?

Avg of the four CAs out of 30Reduced to 24 Assignments marks out of 6 is then added

Final Examination, Mod 2010

(First Professional Examination)
MCBM III Final Examination (written); End of year 1 Total marks: 100

Elements 6 (A,B,C,D) (Immunology, Infection, Control & Inflammation)* (20+35+10+15)=80 marks

Element 7 (Neoplasia)* 20 marks

100 marks (60M:40P) is reduced to a maximum of 70

Types of questions used in the written test: 2010 Objective (30% of total marks)
Multiple choice questions (50* 1 mark)otal marks) Short answer questions (6 * 5 marks) Long answer questions (2* 10 marks)

Final exam, distribution, 2010-eg 1

MCQ (1 mark)
6A (20) 6B (35) 6C (10) 6D (15) E7 (20) Total Number 10 15 5 10 10 50 1 2 6 2

SAQ (5 marks)
1 2

LAQ (10 marks)

0.5 1 0.5

Final exam,distribution, 2010-eg 2

MCQ (1 mark) SAQ (5 marks) LAQ(10 marks)
6A (20) 10 2

6B (35)
6C (10)

15
5

2
1

6D (15)
E7 (20) Total Number

10
10 50

1
1 6 2

Dr.P.K.Rajesh.M.D.

Egs of Common fungi

Yeast-Cryptococcus neoformans Yeast like-Candida albicans Moulds- Dermatophytes Dimorphic fungi- Systemic fungi

Dr.P.K.Rajesh.M.D.

Remember

NO MICRO-ORGANISM WANTS TO CAUSE DISEASE (They like to live in us because of our body temperature-37C)

Dr.P.K.Rajesh.M.D.

Sample question:
Multiple-choice question (choose the single best answer) Which one of the following organism is non motile? A. Escherichia coli B. Helicobacter pylori C. Salmonella typhi D. Clostridium tetani KEY: [ D ]

Theory questions [10 marks]

1 (i) Define Hypersensitivity [2 marks]

(ii) State the differences between immediate and delayedtype hypersensitivity reaction. [4 marks] (iii) With examples, discuss the mechanism of Type III hypersensitivity reaction [4 marks]

Dr.P.K.Rajesh.M.D.

Sample question:
Multiple-choice question (choose the single best answer) Poliovirus predominantly infects the human through A. droplet nuclei B. feaco oral route C. vector transmission D. transplacental route KEY: [ B ]

Poliomyelitis-viral infection

Dr.P.K.Rajesh.M.D.

Sample question:
Multiple-choice question (choose the single best answer) Father of immunization is A. Edward Jenner B. Robert Koch C. Louis Pasteur D. Alexander Fleming KEY: [ A ]

Break-Small pox-eradication

Dr.P.K.Rajesh.M.D.

An example of an OSPE question

(held as part of a multidisciplinary practical examination, end of year 1)
A. Name this method of antibiotic susceptibility testing. (1 mark) Key-Disc diffusion/Kirby Bauer B. Which antibiotic would ideally be chosen?(1 mark) Key-The one with the largest zone of inhibition

Periodic academic monitoring of students

Interactive review sessions (IRS) on topics that have been recently covered (1 IRS:4 Lectures) Students provided marking schemes after every CA Slots scheduled in timetable to provide and receive feedback regarding CA Low achievers (less than 40pc) are called for discussion with their CA papers Symposia are used for all students to be oriented with essential general concepts

Practical session

Emerging and re-emerging infections-2010

Student posters-B15-2010

International papers from symposium

EPIDEMICS2-The second International Conference on infectious disease dynamics Athens, Greece, 2-4 December 2009

International papers from symposium

I International Conference on Antimicrobial Research (ICAR2010), 3-5 November 2010, Valladolid (Spain) Bacteriophage therapy: reappraisal of a potential answer for surgical site infections (abstract code: 773) has been accepted for VIRTUAL presentation at ICAR2010 - I International Conference on Antimicrobial Research.

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