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9 TH Lecture 3rd Month To Birth
9 TH Lecture 3rd Month To Birth
month to birth
Dr. eman khammas alsadi Embryology lecturer Missan university Collage of medicine
Monthly Change
1-the relative slowdown in growth of the head compared with the rest of the body. 1- third month, the head constitutes approximately 1\2 of the CRL
2-fifth month, the size of the head is about 1\3 of the CHL, 3- at birth, it is approximately 1\4 of the length,
4-external genitalia develop to such a degree that the sex of the fetus can be determined by external examination (ultrasound). 5-the intestinal loops have withdrawn into the abdominal cavity. 6-Started muscular activity
During the second half of intrauterine life, weight increases considerably, particularly during the last 2.5 months, when 50% of the full-term weight is added During the sixth month,
1- the skin of the fetus is reddish and has a wrinkled appearance because of the lack of underlying connective tissue. 2- A fetus born early in the sixth month has great difficulty surviving. Although several organ systems are able to function, the respiratory system and the central nervous system have not differentiated yet.
developmental functions age(weeks) 1. Taste buds appear 7 2. Swallowing 10 3. Respiratory movements 14-16 4. Sucking movements 24 5. Some sounds can be heard 24-26 6. Eyes sensitive to light 28 7. a Recognition of form and color occurs post natally.
Time of Birth . Most fetuses are born within 10 to 14 days of the calculated delivery date. If they are born much earlier, they are categorized as premature; if born later, they are considered postmature.
the age determination of an embryo or small fetus must be determined. By combining data on
1- the onset of the LMP 2- fetal length, weight, and other morphological characteristics typical for a given month of development, By using ultrasound: during the 7th to 14th weeks. an accurate measurement depending on CRL Measurements commonly used in the 16th to 30th weeks are 1-biparietal diameter (BPD), 2-head and abdominal circumference, 3-and femur length. An accurate determination of fetal size and age is important for managing pregnancy, especially if the mother has a small pelvis or if the baby has a10 birth defect
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Clinical Correlates:
Low Birth Weight
. Most factors influencing length and weight are 1. genetically determined, 2. environmental factors also play an important role.
Approximately one in 10 babies have IUGR and therefore have an increased risk of 1-neurological deficiencies, 2- congenital malformations, 3-meconium aspiration, 4-hypoglycemia, 5-hypocalcemia, 6-and respiratory distress syndrome (RDS). 7-There are also long-term effects on these infants. For example, they have a greater chance of developing a metabolic disorder later in life, such as 1. obesity, 2. hypertension, 3. hypercholesterolemia, 4. cardiovascular disease, 5. and type 2 diabetes 6. 13 poor mental and physical health in general
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Maternal blood is delivered to the placenta by spiral arteries in the uterus. Erosion of these maternal vessels to release blood into intervillous spaces is accomplished by endovascular invasion by cytotrophoblast cells. These cells, released from the ends of anchoring villi .invade the terminal ends of spiral arteries, where they replace maternal endothelial cells in the vessels' walls, creating hybrid vessels containing both fetal and maternal cells. To accomplish this process, cytotrophoblast cells undergo an epithelial-to-endothelial transition. Invasion of the spiral arteries by cytotrophoblast cells transforms these vessels from small-diameter, high-resistance vessels to larger-diameter, low-resistance vessels that can provide increased quantities of maternal blood to intervillous spaces
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Clinical Correlates
Preeclampsia
is a condition characterized by 1. maternal hypertension, 2. proteinuria, 3. and edema. It may begin suddenly anytime from about 20 weeks' gestation to term and may result in fetal growth retardation, fetal death, or death of the mother. It is a trophoblastic disorder related to failed or incomplete differentiation of cytotrophoblast cells, many of which do not undergo their normal epithelial-to-endothelial transformation. As a result, invasion of maternal blood vessels by these cells is rudimentary. How these cellular abnormalities lead to hypertension and other problems is not clear. 1-placental mosaicism, in which trophoblast cells have genetic defects, 2-and maternal diseases that cause vascular problems, such as diabetes. 19 3- smoking women salso have a higher incidence of preeclampsia
chorion frondosum
As pregnancy advances, villi of the developing placenta on the embryonic pole continue to grow and expand, giving rise to the chorion frondosum (bushy chorion).
The difference between the embryonic and abembryonic poles of the chorion. 1. in the structure of the decidua& 2. the functional layer of the endometrium which is shed 20 during birth
decidua parietalis the chorion laeve comes into contact with the uterine wall (decidua parietalis) on the opposite side of the uterus, and the two fuse obliterating the uterine lumen. Hence, the only portion of the chorion participating in the exchange process is the chorion frondosum, which, together with the decidua basalis, makes up the placenta.
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Birth defect
congenital malformation,
Causes:-
1-unknown cause. 40% to 60%, 2- Genetic factors, 15%; 3-environmental factors 10%; 4-a combination of genetic and environmental influences (multifactorial inheritance) 20% to 25%; 5-twinning causes 0.5% to 1%.
Therefore, minor anomalies serve as clues for diagnosing more serious underlying defects
such as
Types of Abnormalities
A. B. C. D. E. Malformations Disruptions Deformations A syndrome Association
1-Malformations: occur during formation of structures, for example, during organogenesis. They may result in 1- complete or partial absence of a structure 2-or in alterations of its normal configuration. caused by environmental and/or genetic factors. Occur during the third to eighth weeks of gestation
2-Disruptions
result in morphological alterations of already formed structures and are caused by destructive processes. 1- Vascular accidents leading to bowel Artesia 2-defects produced by amniotic bands are examples of destructive factors that produce disruptions 1
3-Deformations : result from mechanical forces that mold a part of the fetus over a prolonged period. Clubfeet,
4-A syndrome is a group of anomalies occurring together that have a specific common cause. This term indicates that a diagnosis has been made and that the risk of recurrence is known.
5- association:
is the non random apperance of two or more anomalies that occur together more frequently than by chance alone. But the cause has not been determind.like VACTERL association A. Vertibral, B. anal C. cardiac D. tracheoesophageal E. renal F. limb anomalies.
Environmental Factors
German measles affecting a mother during early pregnancy caused abnormalities in the embryo,. linked limb defects to the sedative thalidomide Since that time, many agents have been identified as teratogens (factors that cause birth defects)
Thank you
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