DC LIU CHA FLAVONOID

DC LIU CHA EUFLAVONOID

1. Hoa he & ngun dc liu cha Rutin

2.
3. 4. 5. 6. 7.

Ru mo
Nc nc Hong cm Kim ngn hoa Actiso Dc liu thuc chi Citrus, h Cam

DC LIU CHA ISOFLAVONOID

1. 2. 3. 4. Sn dy X can Dy mt Ht c u

PHN B ISOFLAVONOID
H thc vt: kh hp, ch c thc vt bc cao v a s c phn b phn h Cnh bm (Papilionoideae) thuc h u (Leguminosae). lp hai l mm (tr h u) cng c mt s chi v mt s loi phn lp c dn cht isoflavonoid, tuy nhin s lng cht t hn nhiu so vi h u.

PHN B ISOFLAVONOID
H LP HAI L MM Wyethia 8 CHI S LNG*

Virola Boerhaavia Stemona

5 7 3

MT L MM
Iridaceae Belamcanda Iris NGNH HT TRN 7 26

Cupressaceae
Podocarpaceae NM Bryaceae

Juniperus
Podocarpus

6
5

Bryum

TC DNG SINH HC CA ISOFLAVONOID

Mt xng,
Cc vn v tim mch, Phng chng ung th v Cc triu chng tin mn kinh

TC DNG SINH HC CA ISOFLAVONOID

OH OH

HO

HO

Estradiol

Diethylstilboestrol
O OH

OH

O HO

OH

Equol

HO

Genistein

Lin quan gia cu trc v tc dng sinh hc ca cc hormon thc vt

DC LIU CHA NEOFLAVONOID

T mc

HE
Styphnolobium japonicum (L.) Schott., syn. Sophora japonica L., h u. c im thc vt: cy g (15m); l kp lng chim l (9-13 l cht); cm hoa hnh chy u cnh; trng hoa hnh bm mu trng ng; qu loi u khng m. Phn b: Vit nam (Thi bnh), Trung quc, Triu tin, Nht bn.

HE
Ho np v Ho t, trng sau 3-4 nm th thu hoch. Thu hi: thng 7-9 khi thi tit kh ro, thu chm hoa bt u c hoa n. Dc liu l hoa cha n (he m). DVN quy nh hoa n ln khng qu 10%.

HE
Thnh phn ho hc
Flavonoid (Rutin)

OH

HO

O OH

Aglycon: quercetin ng: rutinose (6-O-L-rhamnopyranosyl--Dglucopyranose) Rutin c th chim n 28% (20% DVN) Chit xut
chit bng nc nng, lnh kt tinh rutin. chit bng nc kim carbonat sau acid ha.

O-glc-rha OH O

Tinh ch Rutin: ho tan trong nc nng hoc cn nng.

HE
Cng dng Rutin c hot tnh ca vitamin P, c tc dng lm bn v gim tnh thm ca mao mch, lm tng sc bn ca hng cu.

Rutin dng phng bnh x va ng mch, iu tr

suy yu tnh mch, xut huyt nh chy mu cam, ho ra mu

Ch phm
Rutin-C; Ruton (Dip c + Hoa he)

Ngun dc liu khc chit Rutin

La mch ba gc: Polygonum fagopyrum, h Rau rm.
Cy lng thc, ht c nhiu tinh bt. C kh nng trng vng t ngho, min ni. Thu l (2-3 % rutin) trc khi cy ra hoa.

Cy to ta Ziziphus mauritiana (= Z. jujuba), h To ta.

L cha 1,5% rutin. L 10 19% rutin.

Bch n cho Rutin: Eucalyptus marcorrhyncha,

RU MO
Orthosiphon aristatus, h Hoa mi, Lamiaceae Cy tho, l mc i cho ch thp, cm hoa ngn, gm 6-10 vng, mi vng c 6 hoa, nh di, mc th ra ngoi trng nh ru mo.

B phn dng: l v ngn cy khi cy mi bt u ra hoa.

RU MO
Thnh phn ha hc: 9 flavon; 2 flavonol (kaempferol v quercetin); coumarin; diterpenoid
R3

Ru mo c s dng lu i n , Indo., iu tr bnh thn v bng quang. Nhp vo chu u vo cui TK 19. C tc dng li tiu mnh

H3CO

O OR4

R2O OR1 O

Ru mo l thnh phn chnh trong cc ch phm ch gim cn

NC NC
Oroxylum indicum, h Nc nc, Bignoniaceae. B phn dng: v cy (mu vng, v ng) v ht.

NC NC
Thnh phn ha hc: Baicalein (flavon) Ch phm Nunaxin iu tr m ay, vy nn. Y hc c truyn: cha ho, vim ph qun, au gan.
HO O

HO OH O

Baicalein

ACTIS (artichaud)
Cynara scolymus, h Cc

Cy tho ln, l to di, x su

thnh nhu thy. Cm hoa hnh u (d=15cm), l bc non dng lm thc phm.

Trng Sapa v Lm ng (kh

hu mt). Thu l vo ma thu sau khi hi hoa lm thc phm. Lm kh nhanh n nh dc liu (trnh cc hp cht odihydroxyphenol b oxi ha).

ACTIS
Thnh phn ha hc: cynarin v flavonoid
HO

HO

C H

H C

C O

O COOH OH

Cynarin = acid 1,3-dicafeyl quinic

OH HO OH O C O C H C H OH

HO

C H

H C

COOH

Acid cafeic

Cynarin

l diester cafeic ca acid quinic.

ACTIS
Flavonoid nhm flavon
R
OH

Luteolin
OR

RO

Cynarosid
Scolymosid

Glc
Rut

H
H

OH

ACTIS
Cng dng: cha cc bnh v gan, si bng quang, ph thng, tng tit dch mt Ch phm: t cao mm ch cc dng vin bao Chophytol (Php), Cynaphytol (Vit nam)

KIM NGN
Dc liu l n hoa c ln mt s hoa n ca cy Kim ngn Lonicera japonica Thunb. Hoc

mt s loi khc ca chi

Lonicera, h Kim ngn (Caprifoliaceae)

KIM NGN
c im thc vt
Dy leo, l hnh trng, mc i. C tn Nhn ng v l xanh quanh nm Hoa mu 5, mc xim k l

Phn b
Min rng ni Cao bng, Ho bnh

KIM NGN
Thnh phn ho hc Hoa v l cha flavonoid: cht chnh l luteolin-7rutinosid (Lonicerin = scolymosid)
R
OH

Luteolin
OR

RO

OH

Scolymosid (Lonicerin)

Rut

KIM NGN
Cng dng
Thanh nhit, tiu c Dng tr vim nhim nh vim da, mn nht, vim hng

C th dng c cnh, l kim ngn

DC LIU THUC CHI CITRUS

Dc liu thuc chi Citrus, h Cam
B phn cha nhiu flavonoid thuc chi Citrus ch yu v qu ngoi, v qu gia v dch qu. Flavonoid ca cc loi thuc chi Citrus dng di dng ton phn kt hp vi Vitamin C lm thuc bo v thnh mch. Flavanon: Hesperidin, Naringin

Flavon: Diosmin (DAFLON)