Gold Collection Anti-neoplastic

Cyclosporine

Protects against rejections from organ transplants Does not induce bone marrow depression

 Cyclophosphamide

Alkylating agent of both purine & pyrimidine bases of DNA Txt CLL

 Cisplatins toxicities

 Nephro- & Ototoxicity

 Methotrexate

Antimetabolite of folic acid: ()dihydrofolate reductase

 Leucovorin Rescue

 Can block/reduce Methotrexate = increase folic acid via a reduced folate

 Bleomycin toxicities

 Pneumonitis & pulmonary fibrosis

 Azathiorine

Used in organ transplantation = kidney allografts Allopurinol can increase its activity by (-) its biotransformation to xanthine oxidase

 Chemotherapy used in the txt of Hodgkins disease

 MOPP M = Mechlorethamine - nitrogen mustard O = Oncovin (Vincristine) prevents microtubule assembly P = Procarbazine P = Prednisone - glucocorticoid, inducing apoptosis

 Tamoxifen

(-) estrogen receptor Txt of breast tumors, can see associated endometrial CA

 Flutamide

Antiandrogenic Used w/ Leuprolide (LH-RH analog) Txt prostatic CA

 Megestrol

(-) progesterone receptor Txt endometrial CA

 Fluoxymesterone

Androgenic steroid Txt mammary CA in postmenopausal women

 Methotrexate

Folic acid analog that (-) tetrahydrofolate synthesis by (-) dihydrofolate reductase Txt of ALL Txt of Psoriasis

 Brain tumor Txt

Lomustine Carmustine - Causes pulmonary fibrosis

 Streptozocin

Attaches to cells Txt of pancreatic insulinomas

 Cytarabine (AraC)

Pyrimidine analog DOC for AML

 Dactinomycin

 Used for Wilms tumor & rhabdomyosarcoma

 Etoposide

 Used for oat cell CA

 Paclitaxel

Used for ovarian CA

 Amifostine

 Can decrease nephrotoxicity due to chronic use of Cisplatin