This document discusses the properties and effects of several psychoactive plants and substances, including Datura, Atropa belladonna, Hyoscyamus niger, Cannabis sativa, and cocaine. It provides details on the active compounds in each, their pharmacological effects, mechanisms of action, routes of administration, signs and symptoms of intoxication, fatal doses, and potential medical uses and legal issues. The document also compares different varieties of Datura plants and cannabis preparations like marijuana and hashish.
This document discusses the properties and effects of several psychoactive plants and substances, including Datura, Atropa belladonna, Hyoscyamus niger, Cannabis sativa, and cocaine. It provides details on the active compounds in each, their pharmacological effects, mechanisms of action, routes of administration, signs and symptoms of intoxication, fatal doses, and potential medical uses and legal issues. The document also compares different varieties of Datura plants and cannabis preparations like marijuana and hashish.
This document discusses the properties and effects of several psychoactive plants and substances, including Datura, Atropa belladonna, Hyoscyamus niger, Cannabis sativa, and cocaine. It provides details on the active compounds in each, their pharmacological effects, mechanisms of action, routes of administration, signs and symptoms of intoxication, fatal doses, and potential medical uses and legal issues. The document also compares different varieties of Datura plants and cannabis preparations like marijuana and hashish.
Flowers are bell shaped Hells bells / devils trumpet Fruits thorn apple up to 500 seeds Yellowish brown Look like capsicum seeds All parts are poisonous Fruits flowers seeds High concentration in roots and seeds
Hyoscine ( scopolamine ) Hyoscyamine Traces of atropine Block Ach receptors, Inhibit muscarinic effect of Ach Stimulate higher centers, then depress RS stimulate then depressed Vagolytic action, stimulate heart
Through GIT, RS, Skin, Conjunctiva Metabolized in liver Excrete through urine Contact with leaves and flowers Dermatitis
Eating seeds- within half an hour Decoction- few mins Alkaloids- immediate
8 Ds Dryness of mouth Dysphagia Dilatation of cutaneous blood vessels Dilated pupils Dry hot skin Drunken gait Delirium Drowsiness Death Fatal dose 15-30 mg hyoscine 100-125 seeds
Fatal period 24 hrs Emetics Stomach wash Activated charcoal KMnO4 Tannic acid Antidote Physostigmine Pilocarpine Delirium - Short acting barbiturates Light diet Control high temperature External Asphyxial Internal Seeds in GIT Stomach Lungs Seeds resist putrefaction Large thick Kidney shaped Dark yellowish brown Double edge border Multiple depressions Odourless Bitter Curved outword Small thin Rounded Pale yellow Simple Smooth Pungent Pungent Curved inward Stupefying poison robbery, kidnapping, rape. Rail road poison Suicide rare, accidental in children Abortifacient Aphrodisiac Used as an adulterant in country liquor kick effect Mixed with tobacco and ganja and liquor Not responsible for criminal acts
Europe and Asia Atropine, 1-hyoscyamine Root has 82-97 % hyoscyamine Signs and symptoms as datura Fatal dose 100-130mg atropine Accidental ingestion of eye drops preparation Marijuana Marihuana Hashish Pot Hash Grass weed
Cannabinol THC Benzopyrene
Preparations Majum bhang Hash oil hashish and marijuana Routes of intake Smoking joints/reefers/pipes Milk bhang Actions Depending on dose Stimulant / sedative / hallucinogenic Catecholamine release tachycardia Inhibit sympathetic reflex - hypotension Stage of excitement Stage of narcosis
Fatal dose Bhang 10 g/kg body wt Charas 2 g Ganja 8 g Fatal period 12 hr Lavage Strong tea coffee Artificial respiration Saline purgatives Glucose naloxone thiamine Dizepam
PM findings mostly asphyxial Medicolegal importance Accidental overdose As stupefying agent As aphrodisiac Run amok Ready to die in the battle Homicidal mania Impulse to murder Criminal responsibility Cultivation restricted by law