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Paramyxovirus Lec
Paramyxovirus Lec
viruses
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Paramyxo viruses
• Paramyxoviruses are enveloped RNA virus.
• Contain one piece single stranded RNA.
• Surface spikes are: hemagglutinin,
nuraminidase and fusion protein.
• Paramyxo viruses are:
Measles virus
Mumps virus
Respiratory syncytial virus
Parainfluenza virus 2
Paramyxo viruses
Virus Hemagglutinin Nuraminidase Fusion
protein
Measles + - +
Mumps + + +
Respiratory - - +
syncytial
Parainfluenza + + +
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Paramyxoviridae structure
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Measles virus
Measles
virus
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Measles virus
• Reservoir
– Humans
• Transmission
– Person-to-person via droplets during
prodormal period and a few days after
symptos.
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Measles virus
• Incubation period
– Average 10-14 days.
• Infectious period
– From 4 days prior to rash onset to 4 days
after rash onset.
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Measles pathogenesis
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Clinical features
• Prodrome:
• Fever,
• cough,
• coryza,
• conjunctivitis.
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Control measures
• Prevented by immunization with a live attenuated
vaccine.
• Should be administered with mumps and rubella
as MMR, or with mumps, rubella and varicella as
MMRV
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Mumps virus
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Transmission
• Reservoir: Human
• Transmission: Respiratory droplet nuclei.
• Incubation period: 18-21 days.
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Mumps Pathogenesis
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Clinical conditions
• Prodromal symptoms: Fever, myalgia,
malaise, headache.
• Followed by acute onset of unilateral or
bilateral tender, self-limited swelling of the
parotid gland (s).
• Complications:
Orchitis, Ophoritis
Sterility, Pancreatitis
CNS involvement
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Laboratory Diagnosis
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Mumps Vaccine
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Respiratory Syncytial
Virus (RSV)
Resp. Sync. Virus
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Clinical Features
• Upper respiratory infection in older children
and adults:
Fever, Rhinitis, Pharyngitis & otitis media
• Lower Respiratory Infection in infants:
Bronchiolitis, Pneumonia, Cough, Poor
feeding, lethargy, Hypoxemia, Respiratory
Distress, Apnea
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RSV Bronchiolitis- clinical features
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Parainfluenza viruses
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Parainfluenza viruses
• Serotypes 1 and 2 cause cold-like symptoms,
bronchitis and croup.
• Serotypes 3 causes infection of children in lower
respiratory tract.
• Diagnosis
– Virus culture
– Syncytia formation
– A 4 foled rise of antibody titer.
– PCR
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