Diabetes mellitus with its accompanying

vascular complications is on a rise

globally and a similar trend has been
observed in Libya too. Early detection,
effective monitoring and timely
management is important to control this
growing problem. Various studies have
shown microalbuminuria as an early
indicator of nephropathy in diabetes
mellitus. The present study is aimed at
evaluating microalbuminuria and HbA1C
in type 2 diabetes mellitus.
Introduction
Sixty subjects in the age group ranging
from 40 to 70 years have been
recruited from Seventeenth February
Teaching Hospital, Al- Baida for the
study, twenty controls with no history
of diabetes, twenty recently
diagnosed diabetics under treatment
and twenty old cases of diabetes
mellitus who have suffered an episode
of coronary artery disease (CAD) or
cerebrovascular accident (CVA).
Venous samples were drawn after an
overnight fast for glucose,
glycosylated hemoglobin, urea and
Creatinine and 24 hours urine sample
for albumin estimation. The tests were
performed using authenticated kits
and Cobas integra 400 analyzer.
The present study has shown a significant correlation of
glycosylated hemoglobin and urinary albumin in diabetes
mellitus with vascular complications. Hence measurement of
glycosylated hemoglobin along with microalbuminuria is
significant as an early marker in predicting nephropathy in
uncontrolled type 2 diabetes mellitus with complications.

Conclusion
Materials and methods
Results
Slightly high levels of fasting blood glucose
(p=0.03) and glycosylated hemoglobin (p=0.02)
but normal urea, Creatinine and 24 hours urinary
albumin were observed in diabetics under
treatment when compared with controls. However,
diabetics with complications showed higher levels
of fasting blood glucose (p<0.0001), glycosylated
hemoglobin (p<0.0001), serum urea, Creatinine
and microalbuminuria. There is positive
correlation of glycosylated hemoglobin and
albuminuria in the diabetic group with coronary
artery and cerebrovascular complications.
ROLE OF HbA1C AND MICROALBUMINURIA AS EARLY MARKERS OF NEPHROPATHY
IN TYPE 2 DIABETES MELLITUS

Dr.Nura Naseb Mohamed
1
,khalid saleh gharib
2
, Shakila srikumar
3
,Peela Jagannadha rao
3
Abd Rehaman Said
3
,Peela Laxmi Teja
4
and Dr.Yedla Ramesh Naidu
5
.

1.Department of biochemistry, Faculty of Medicine, University of Benghazi, Libya. 2. Biochemistry Department, Faculty of Medicine, Omar Al-Mukhtar University, Al-
Baida. 3. Department of biochemistry, Faculty of Medicine, Quest International University perak,Ipoh,Malaysia. 4. Great Eastern Medical school,Srikakulam,India 5.
Department of Medicine, Andhra Medical College, Visakhapatnam,India.

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