Avian INFLUENZA is an infection caused by avian (bird) influenza (flu) viruses. Infected birds shed influenza virus in their saliva, nasal secretions, and feces. Domesticated birds may become through direct contact with infected waterfowl. Alveolar damage spread by macrophages, neutrophils, and activated lymphocytes.
Avian INFLUENZA is an infection caused by avian (bird) influenza (flu) viruses. Infected birds shed influenza virus in their saliva, nasal secretions, and feces. Domesticated birds may become through direct contact with infected waterfowl. Alveolar damage spread by macrophages, neutrophils, and activated lymphocytes.
Avian INFLUENZA is an infection caused by avian (bird) influenza (flu) viruses. Infected birds shed influenza virus in their saliva, nasal secretions, and feces. Domesticated birds may become through direct contact with infected waterfowl. Alveolar damage spread by macrophages, neutrophils, and activated lymphocytes.
NIM : 09020005190 AVIAN INFLUENZA Avian influenza is an infection caused by avian (bird) influenza (flu) viruses. Occur naturally among birds
It carry the viruses in their intestines, but usually do not get sick from them. Very contagious among birds
Make some domesticated birds, including chickens, ducks, and turkeys, very sick and kill them.
Infected birds shed influenza virus in their saliva, nasal secretions, and feces. Infected when they have contact with : contaminated secretions excretions surfaces that are contaminated with secretions excretions from infected birds. Domesticated birds may become through direct contact with infected waterfowl other infected poultry through contact with surfaces materials that have been contaminated with the virus PATOGENESIS Genetic mutation at position 627 Virus infection happens after virus enter host cell after attachment of various spikes and specific receptor replicates in the nasopharyngeal and gastrointestinal tract With jus alteration of one amino acid, it could infect humans Cause transmission between human and human PATHOLOGICAL FINDINGS alveolar damage has been shown to spread with hyaline membrane formation uneven lymphoplasmacytic interstitial infiltrates, bronchiolitis with squamous metaplasia, and pulmonary congestion with varying degrees hemorrhage. alveolar damage spread by macrophages, neutrophils, and activated lymphocytes have been detected in patients who died within 2 weeks after onset of illness. apoptosis in alveolar cells and infiltrating leukocytes are prominent findings. CLINICAL SYMPTOMS Incubation period 4-8 days High fever Cough Sore throat muscle aches to eye infections pneumonia severe respiratory diseases other severe and life-threatening complications
LABORATORY DIAGNOSIS examination of throat swabs and nasal fluids. To test the confirmation of H5N1 virus infection, the examination should be done by: (a) isolating the virus (b) detection of the H5N1 genome using the Polymerase Chain Reaction (PCR) using specific primer pair (c) imunoflouresensi test antigens using monoclonal antibodies against H5 (d) examination of an increase in antibody titer against H5N1 (e) examination by western blotting method to the H5- specific.
TREATMENT AND VACCINATION FOR H5N1 VIRUS IN HUMANS two antiviral medications commonly used for influenza are amantadine dan rimantadine.
Two other antiviral medications, oseltamavir and zanamavir
There currently is no commercially available vaccine to protect humans against H5N1 virus that is being seen in Asia and Europe. However, vaccine development efforts are taking place. RISK ON HUMAN HEALTH Zoonosis
Virus AI is a very specific species but there are chances to infect human
It happens when there is contact with bird or contaminated area
This can be prevented by wearing mask,gloves , spectacles
SUMMARY Infection cause by bird Widely spread among birds Could spread through contaminated enviroment Handling an infected bird could cause infection Virus survive in enviroment for long period of time Test that can be taken Chest x ray Auscultation