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GRANULOPEISIS
GRANULOPEISIS
Sri Mulatsih
Subbagian Hematologi-onkologi,
IKA FK UGM/RSUP Dr. Sardjito
Yogyakarta
2008
Cont
HEMATOPOEISIS
GRANULOPEISIS
Is
TRANSCRIPTION FACTOR
GRANULOPEISIS
GRANULOPOEISIS
GRANULOPOEISIS
GRANULOPOEISIS
GRANULOPEISIS
GRANULOPEISIS
GRANULOPEISIS
BONE MARROW
GRANULOPEISIS
MYELOBLAST
MYELOCYTE
METAMYELOCYTE
BANDS LEUKOCYTE
SEGMENTED NEUTROPHIL
EOSINOPHULIC LEUKOCYTE
BASOPHILIC GRANULOCYTE
EOSINOPHILIC LEUKOCYTE
G-CSF
Act
Granulopoeisis
In
peripheral:
6-12 hours
50% in axial stream
50% in marginal pool
Migrate into extravascular 1-2
day-apoptosis
Nutrophil
Segmented nucleus
Highly condensed
chromatin
Full complement
granules and
secretory vesicles
antimicrobial (BPI)
Secondary (specific) granules-lactoferrin
Tertiary (gelatinase) granules extravaculare
migration
Secretory vesicles
BPI
Functions:
Permeabilizing bacterial
membrane
Neutralizing endotoxin
Opsonizing bacteria
--phagocytosis
Defensins
4 kD cationic protein
Cytotoxic activity:
Bacteria
Fungi
Parasites
Viruses
Lysozyme:
Clinical correlation
Neutrophilia:
bone marrow
Expansion of the progenitor pool or
shortening of the mitotic cycle
Failure to exit the circulation
Neutrophilia
Physiologic
Infection
Inflammations
Acute hemorrhage or hemolysis
Corticosteroid
Persistent inflammatory response
Leukemoid reaction
Post splenectomy
Acute response:
Chronic:
Neutropenia
Decreased
production
Increased utilization
Peripheral destruction
Increased vascular margination
Neutropenia
Pseudo-neutropenia
Infection-Induced
Drug-Induced
Immune
Hemolytic anemia
Autoimmune disease
Chronic
Benign
Congenital neutropenia
Inhibitor
of CFU-GM
Or absence on local cytokine production
MIGRATION OF
GRANULOCYTE