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Adverse Effects of Antimicrobials
Adverse Effects of Antimicrobials
Adverse Effects of Antimicrobials
EFFECTS OF ANTIMICROBIAL
CHEMOTHERAPY"
Case Number 2
a. Hepatitis
b. Hypotension
c. Nephrotoxicity
d. Anaphylactic shock
Case No 3
A 52 year old man presents with abdominal pain,
which has been worsening over the past week.
He is now having 8-10 watery stools a day and
mild cramping pain. About 10 days ago reveled
that he has completed a course of
amoxicillin/clavulanic acid for pneumonia. A
stool culture is negative but specific toxin assay
is positive. The condition was diagnosed as
Pseudomembranous colitis.
2. Pseudomembranous colitis is a
frequent complication of the following
antibiotic:
a. Penicillin G.
B. Clindamycin.
C. Streptomycin.
D. Vancomycin
Case No: 4
A 59-year-old man received one of the macrolide
groups of antibiotics for cough treatment after he has
been taking numerous over-the-counter cold
medications without relief. After three days therapy
the patient suffered from cardiac arrhythmia. What is
the possible explanation for this arrhythmia?
Case No: 5
The patient received erythromycin which inhibited
hepatic metabolism of the antihistaminic present in
OTC cough therapy, resulting in increased serum
concentration of the antihistaminic and appearance of
one of antihistaminic side effects which is arrhythmia.
Case Number 6:
Case Number 7:
Remember
Penicillins
Hypersensitivity Reactions
GIT symptoms with oral
penicillins
Aminoglycosides
Ototoxicity
Neurotoxicity
Nephrotoxicity
Chloramphenicol
Anemia
Types ?
Drug Interactions
Fluoroquinolne
Tetracycline
Photosensitivity
SULPHONAMIDES
Hypersensitivity
Haemolytic anemia ?
Kernictrus ?