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Lec 5 WBC
Lec 5 WBC
Medicine
PSL 222
WBC
Lecture 5
Dr. S.Bashir
Lecture objectives
Describe:
The characteristic features & functions
of the different WBC types.
Define inflammation & describe the
events involved.
Define leucocytosis, leucopenia, &
leukemia & state possible causes.
Dr. S.Bashir
WBC
Classification of WBC
Granulocytes
i) Neutrophils
ii) Eosinophils
iii) Basophils.
Agranulocytes
i) Lymphocytes
ii) Monocytes
Bases of classification?
Appearance after staining with Wrights stain
Dr. S.Bashir
Dr. S.Bashir
Neutrophils
Inflammation
Dr. S.Bashir
Dr. S.Bashir
Neutrophils
EOSINOPHILS
10
EOSINOPHILS
11
BASOPHILS
12
They are
non-phagocytic.
Dr. S.Bashir
13
MONOCYTES
14
15
Macrophage:
Tissue scavengers
Macrophages
phagocytose bacteria .
Dr. S.Bashir
16
Phagocytosis
Dr. S.Bashir
17
Macrophage:
Antigen presentation
In addition to
phagocytosis ,
macrophages help
initiate specific
immunity by
presentation of
antigens to
lymphocytes.
Dr. S.Bashir
18
LYMPHOCYTES
19
LYMPHOCYTES
20
Dr. S.Bashir
21
4,000 to 11,000
Neutrophils
Lymphocytes
2,000
to
7,500/L
Monocytes
1,500
to
3,500/L
200
to
800
Dr. S.Bashir
Eosinophils
40
to
440
<100
Basophils
22
23
Leukemia
Definition?
Extreme leukocytosis
Possible causes?
Dr. S.Bashir
24
Myeloid Leukemia
AML
CML
Acute myeloblastic chronic myelocytic
Dr. S.Bashir
25
Lymphoid leukemia
ALL
CLL
Acute lymphoblastic
chronic lymphocytic
Dr. S.Bashir
26
Dr. S.Bashir
27
Leukopenia
An inadequate number of
WBCs.(< 4,000 /l)
Causes of leukopenia :
Viral infections,
sever bacterial infections,
and bone marrow
disorders.
Dr. S.Bashir
28
Thank You
Dr. S.Bashir
29