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Chapter 1 Intro To Biophysics
Chapter 1 Intro To Biophysics
BIOPHYSICS
Prepared by
Nurdiana Samsulrizal &
Dzulsuhaimi Daud
LEARNING OUTCOMES
Students will be able to:
Define the fundamental concepts of
biophysics.
Understand the integration of physical
theory into biological processes.
Identify the biophysics tools for biology and
health industry.
INTRODUCTION
Understanding biology using some ideas
from physics/chemistry/maths etc.
Need to know biology in order to do
biophysics.
Using physics to understand biology.
Not biology to understand physics!!
WHAT IS BIOPHYSICS
Physics for biologists, or
methods applied to biology
physical
WHAT IS BIOPHYSICS?
Biophysics is an interdisciplinary field which
applies techniques from the physical sciences
to understanding biological structure and
function (British Biological Society).
Biophysics is an interdisciplinary science that
applies the theories and methods of physical
sciences, to questions of biology (Wikipedia).
Biophysics is the application of the analytical
viewpoints, methods and/or instrumentation of
physics to the investigation of biological problems
(European Biophysics Society).
STUDY OF BIOPHYSICS
Biology and molecular biology
Gene regulation, single protein dynamics,
bioenergetics and biomechanics.
Structural biology
Nucleic acid, lipids, carbohydrates and their
complexes.
Bioinformatics
Sequence alignment, structural alignment and
protein structure prediction.
Pharmacology
Channel biology, biomolecular interactions,
cellular membranes.
NUCLEAR MAGNETIC
RESONANCE
SPECTROSCOPY
HOW DO BIOMOLECULES
ASSEMBLE AND INTERACT?
Synthesize of Proteins
HOW DO BIOMOLECULES
ASSEMBLE AND INTERACT?
APPLICATION OF
BIOPHYSICS
Quantitative analysis of the physical
and
chemical aspect of the functions of biological
molecules and organism.
Theoretical
biophysics
tries
to
use
mathematical and physical models to explain
life processes.
In
physiological
biophysics,
physical
mechanisms have been used to explain such
biological processes as the transmission of
nerve impulses, the muscle contraction
mechanism, and the visual mechanism.
Radiation biophysics studies the response of
organisms to various kinds of radiations.
APPLICATION OF
BIOPHYSICS
APPLICATION OF
BIOPHYSICS
Fluorescence
microscopy
of
endothelial
cells
using three labels.
Red
labels
the
mitochondria, green
labels the F-actine
cytoskeleton
and
blue
labels
the
nucleus.
REVIEW
Physics
Mathema
tics
Chemistr
y
Biomolecular
interactions
Gene therapy
BIOLOG
Y
Regulation of
gene
Protein
structure &
functions