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How To Do Meta Analysis: Arindam Basu
How To Do Meta Analysis: Arindam Basu
Analysis
Arindam Basu
Associate Director,
Fogarty International Training
Program
Kolkata, India
February, 2005
arin.basu@gmail.com
phone: 919830153666
Quantitative : numbers
Systematic : methodical
3000
Number of Publications
2500
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93-94
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2003-4
Year of Publications
Pubmed/Medline
Embase
Boolean Logic OR
acute myocardial
infarction. How should we
The Search
Plan of Action
ARE THE STUDIES ELIGIBLE FOR MA
(STEP I)?
NO
DISCARD
YES
Analyze Data
Statistically
Combine data to arrive at a summary, 3 measures
Test of heterogeneity
Two Graphs
Forest Plot
Funnel Plot
Test of Heterogeneity:
Chi-square (df=21) = 31.5
P-Value = 0.07
Forest Plot
Choosing a model
publication bias
QUOROM guidelines
conduct if it is reasonable
to assume underlying Rx
effect is SAME for all
studies
Pooling: Mantel Haenszel
OR
Test: test of heterogeneity
If significant, go for
random effects model
short 95% CI for summary
smaller summary estimate
OR=0.77 [0.72,0.83]
Conduct if test of
heterogeneity is
significant (shows
heterogeneity)
Assume that TRUE log
odds ratio comes from a
normal distribution
Method: DerSimonian
Lairs method (DSL) of
calculating Odds Ratio
OR=0.78 [0.69,0.88]
Bias in Metaanalysis
[http://www.consort-statement.org ]
Publication Bias
Guidelines
A Good Checklist
Use it for reporting
Meta Analysis
Systematic reviews
Huge Checklist
[http://faculty.ucmerced.edu/wshadish /]
Free Software:
Non-free
Summarizing...