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Lipid Metabolism: Dr. Hesty Wahyuningsih Dept. Biokimia
Lipid Metabolism: Dr. Hesty Wahyuningsih Dept. Biokimia
Out line
Overview of Human Metabolism
Lipids of Physiologic Significance
Lipid metabolism:
Degradation
Digestion
Absorption
Lipid transport
-oxidation
Biosynthesis
Overview of Human
Metabolism
LIPID
: hydrocarbon, hydrophobic.
Consist of:
-
triacylgycerol,
phopholipid,
cholesterol
LIPID METABOLISM
Degradation
Digestion
Absorption
Lipid transport
-oxidation
Biosynthesis
fatty acid synthesis
cholesterol synthesis
All other fatty acids are re-esterified with the 2monoglycerides to form triglycerides which are
incorporated into lipoprotein particles called
chylomicrons which enter the lymphatic vessels.
Lipoprotein
1. Chylomicron: transport lipid which form from
digesting and absorbing (>Triasilgliserol)
2. VLDL: transport triacilgliserol from liver
(>Triasilgliserol)
3. LDL : rich of cholesterol, forming from VLDL
metabolism
4. HDL : rich of cholesterol at joint cholesterol
secretion process from the tissue (> Protein)
3 jalur metabolisme
lipoprotein
1. Metabolisme
Eksogen
2. Metabolisme
Endogen
3. Reverse
Cholestrol
Transport
exogne
FAT TISSUES
endogne
FAT TISSUES
REVERSE COLESTROL
TRANSPORT
Figure 24.13
Energy
Glucose
40 kcal
Glycogne
600 kcal
Protine
25.000 kcal
Lipid
100.000 kcal
- Oksidasi
setelah memasuki
sel asam lemak
masuk ke matriks
mitokondria
degradasi lebih
lanjut.
Step 1.
Asam lemak diaktivasi
dgn enzim Acyl CoA
synthase /
thiokinase
Untuk masuk ke
dalam matrik
mitokondria,
asam lemak yg
sudah diaktivasi
memerlukan
karier karnitin
-Karnitin
palmitoiltrans
ferase I :
membran luar
-Karnitin
palmitoiltrans
ferase II :
membran
dalam
STEP 2:
Berperan pada
pembentukan
rantai
Setelah di dalam
mitokondria.....
ganda antara atom C2
C3.
Mempunyai akseptor
hidrogen FAD+.
STEP 3:
Mengkatalisis hidrasi
trans enoyl CoA
Penambahan gugus
hidroksi pada C no. 3
Menghasilkan 3-Lhidroksiasil Co. A
STEP 4:
Mengkatalisis oksidasi
-OH pada C no. 3 / C
menjadi keton
Akseptor elektronnya :
NAD+TEP
STEP 5 :
Thiolase
mengkatalisis
pemecahan ikatan
thioester.
Acetyl-CoA dilepas
dan tersisa asil ko A
menghasilkan fatty
acyl-CoA (yang telah
berkurang 2 C).
Figure 24.14