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The Cell Cycle
The Cell Cycle
room temperature
36C
1.
Cell-cycle control system triggers the major events of the cell cycle
2.
The cell-cycle control system depends on cyclically activated cyclindependent protein kinases (Cdks)
3.
4.
5.
6.
S phase
1.
2.
3.
Mitosis
1. M-Cdk drives entry into mitosis
2. Dephosphorylation activates M-Cdk at the onset of
mitosis
3. Condensin helps configure duplicated chromosomes for
separation
4. The mitotic spindle is a microtubule-based machine
5. Centrosome duplication occurs early in the cell cycle
6. M-Cdk initiates spindle assembly in prophase
7. The completion of spindle assembly in animal cells
requires nuclear envelope breakdown
8. The APC/C triggers sister-chromatid separation and the
completion of mitosis
9. Unattached chromosomes block sister-chromatid
separation: The spindle assembly checkpoint
Mechanism controlling
cell-cycle entry and
S-phase initiation
in animal cells