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Antimicrobial Agents: General Consideration
Antimicrobial Agents: General Consideration
Antimicrobial Agents: General Consideration
GENERAL CONSIDERATION
NUR PERMATASARI
Antibiotics
Substances produced by various species
of microorganisms: bacteria, fungi,
actinomycetes- that suppress the growth
of other microorganisms and to destroy
them.
Today the term ATB extends to include
synthetic antibacterial agents:
sulfonamides and quinolones.
Resistance
Failure to reach the target ( absence/ mutation
of porin, anaerobic condition, efflux pump
mechanism)
Pregnancy
Drug allergy
Local factor
-pus, hemoglobin in infected
hematoma, pH, anaerobic, vascular
supply
- the presence of foreign body
Disanvantages of combinations of
antimicrobial agents
Risk of toxicity
The selection of multiple-drug
resitant
Increased cost
Antagonism effect
Superinfections
The appearance of bacteriological
and clinical evidence of a new
infection during the chemotherapy
of a primary one
Very dangerous
Very difficult to eradicate
Broad spectrum, prolonged
administration
Misuses of antibiotics
Treatment of untreatable infection
Therapy of fever of unknown origin
Improper dosage
Inappropriate reliance on
chemotherapy alone
Lack of adequate bacteriological
information