Intra Uterin Fetal Death

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INTRA UTERINE

DEATH
Dr.P.S.Hettipathirana
MBBS(COL),MD(Obs & Gyn),MRCOG(UK)
Senior lecturer/ Consultant Obstetrician & Gynaecologist

Definition:
Baby delivered with no signs of life, known

to have died after 24 completed weeks of


pregnancy
(In Sri Lanka 28 weeks for statistical
purposes)

Causes
Fetal
Placental
Maternal
Unexplained

Causes
Fetal causes
Chromosomal & Genetic anomalies
Birth defects
Non immune hydrops
Infections CMV,rubella, parvo B19,Herpes,malaria
Cord accidents

Placental
Abruption
Placental insufficiency
Intrapartum asphyxia
Twin to twin transfusion Syndrome
Chrioamnionitis

Causes
Maternal
Antiphospholipid antibody
Diabetes
Hypertention
Trauma
Abnormal labor Sepsis
Acidosis/ Hypoxia
Uterine rupture
Post term pregnancy Drugs
Thrombophilia Cyanotic heart disease
Epilepsy Severe anemia

Unexplained - majority

Diagnosis
Absence of uterine growth
Loss of fetal movement
Absence of fetal heart Pinnard/CTG
Disappearance of the signs & symptoms of

pregnancy
Imaging Spalding sign

U/S 100% accurate

Diagnosis

History

Family history
Recurrent abortions
deep vein thrombosis/ Pulmonary emboloism
Congenital anomalies, Abnormal karyotype
Maternal History
Maternal medical conditions
Deep vein thrombosis/Pulmonary embolism
Diabetes mellitus
Hypertention
Thrombophilia
SLE,Autoimmune disease
Severe Anemia
Epilepsy
Consanguinity

Past Obstetric History


Baby with congenital anomaly
hereditary condition
IUGR
Placental abruption
Intra uterine death
Recurrent abortions
Current Pregnancy
Maternal age
Hypertention,DM
Smooking , alcohol, or drug abuse
Abdominal trauma
Cholestasis
Placental abruption
PROM or PPROM

Evaluation of IUD fetus


Infant description

Malformation
Degree of maceration
Colour - pale,plethoric
Umbilical cord

Entanglement-neck, arms, ,legs


Hematoma or stricture,Number of vessels
Placenta
Weight
Adherent clots
Structural abnormality
Velamentous insertion
odema/ hydropic changes

MANAGEMENT
Breaking the bad news
Delivery
Investigation cause/complications
Psychological counseling
Rh negative Anti D immunoglobulin

(Rhogam) at the time of diagnosis

Investigation
Cause
FBC
Blood Gp & antibody screen
HbA1 C
Kleihauer Betke test look for feto maternal haemorrhage
Serological screening for Rubella,CMV, Toxoplasma
Syphylis, Herpes & Parvovirus
Thrombophilia screening (antithrombin III,Protein C & S , factor IV
leiden, lupus anticoagulant, anticardiolipin antibodies)
Fetal and placental autopsy

Maternal Complication
Coagulation tests

-DIC

DELIVERY
Immediate delivery
sepsis,ruprured membranes,placental abruption,eclampsia

Expectant approach:
80% goes into spontaneous labour within 2-3 weeks
Risk DIC if wait for > 4 weeks
Emotional burden

Active approach:
emotional burden, risk of chorioamnionitis, and risk of DIC (if >5wks)
Induction of labour can be initiated at any time.

DELIVERY
Always try to achieve vaginal delivery
Unless contraindicated eg : Placenta previa

Methods
ARM & syntocinon
Prostaglandin
Misoprostol

Post partum
Suppression of Lactation
Bromocriptine
Cabergoline

Counselling Bereavement care

THANK YOU

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