Professional Documents
Culture Documents
Atherosclerosis Sanzhar Zhetkenev
Atherosclerosis Sanzhar Zhetkenev
By Sanzhar Zhetkenev
Definition
The term atherosclerosis, comes from the Greek atheros (gruel or
Risk Factors
The cause or causes of atherosclerosis have not been determined
with certainty.
Epidemiologic studies have identified predisposing risk factors:
Unchangeable risk factors
Age
Male gender
Men are at grater risk than are premenopausal women, because of the
protective effects of natural estrogens.
Causes
Lifestyle:
Hyperlipidemia
Pathology
The
lesions
associated
with
atherosclerosis are
of three types:
The fatty streak
The
fibrous
atheromatous
plaque
Complicated
lesion
The latter two are
responsible for the
clinically significant
manifestations of the
disease.
Response-to-injury hypothesis
1. Chronic endothelial injury
2. Accumulation of lipoproteins
3. Monocyte adhesion to the endothelium
4. Platelet adhesion
5. Factor release
6. SMC proliferations and ECM production.
7. Lipid accumulation
Symptoms
Atherosclerosis symptoms depend on which arteries are
affected. For example:
Atherosclerosis in heart arteries, have symptoms
similar to those of a heart attack, such as chest pain
(angina).
Atherosclerosis in the arteries leading to brain, have
symptoms such as sudden numbness or weakness in
your arms or legs, difficulty speaking or slurred speech, or
drooping muscles in your face.
Atherosclerosis in the arteries in arms and legs,
produces decreased blood flow is called peripheral artery
occlusive disease (PAOD).have symptoms such as leg
pain when walking
Sometimes atherosclerosis causes erectile dysfunction in
men.
blood clot, your doctor may insert a clot-dissolving drug into your
artery at the point of the clot to break it up.
Bypass surgery. Your doctor may create a graft bypass using a
vessel from another part of your body or a tube made of synthetic
fabric. This allows blood to flow around the blocked or narrowed
artery.
Lifestyle changes can help prevent or slow the progression of
atherosclerosis.
Stop smoking.
Exercise most days of the week.
Eat healthy foods
Manage stress
manage the condition of high cholesterol, high blood pressure,
diabetes or other chronic disease
References
http://www.nhlbi.nih.gov/health/health-
topics/topics/atherosclerosis
http://www.webmd.com/heart-disease/what-isatherosclerosis