DRUG STUDY

INPARTIAL
FULFILLMENT
OF RLE 104

SUBMITTED BY:
AGUILING, ADRIAN D.

(PIPERAXILLIN SODIUM TAZOBACTAM SODIUM & SILVER

SULPHADIAZINE CREAM)
PIPERACILLI Na & TAZOBACTAMNa
PIPERACILLI Na & TAZOBACTAMNa

Name of the Drug Classificat-ion Indication Action Adverse Effects Nursing

Considerations

Piperacillin Sodium Antibiotic • Appendicitis and • Piperacillin: Binds to CNS: SEIZURES • Assess patient for
Extended spectrum peritonitis bacterial cell wall (HIGHER DOSES) , infection (vital signs;
Tazobactam Sodium penicillin, beta- • Skin and skin structure membrane, causing cell confusion, dizziness, appearance of wound,
lactamase inhibitor infections death. Spectrum is headache, insomnia, sputum, urine, and
2.25 gm TIV q 8hrs x 7 • Gynecologic infections extended compared lethargy. stool; WBC) at
days • Community-acquired with other penicillins beginning of and during
and nosocomial • Tazobactam: Inhibits GI: PSEUDOMEMBRA therapy
pneumonia caused by beta-lactamase, an NOUS
piperacillin-resistant, enzyme that can COLITIS, diarrhea, • Obtain a history before
beta-lactamase– destroy penicillins constipation, drug- initiating therapy to
producing bacteria induced hepatitis, determine previous use
nausea, vomiting. of and reactions to
penicillins or
GU: interstitial nephritis. cephalosporins.
Persons with a negative
Derm: rashes (↑ in history of penicillin
cystic fibrosis patients), sensitivity may still have
urticaria. an allergic response

Hemat: bleeding,
leukopenia,
neutropenia,
thrombocytopenia.
Name of the Drug Classificat-ion Indication Action Adverse Effects
Piperacillin Sodium Local: pain, phlebitis at
IV site.
Tazobactam Sodium
Misc: HYPERSENSITIV
2.25 gm TIV q 8hrs x 7 ITY REACTIONS,
days INCLUDING
ANAPHYLAXIS AND
SERUM SICKNESS ,
fever (↑ in cystic fibrosis
patients), superinfection
Nursing
Considerations
• Obtain specimens for
culture and sensitivity
prior to initiating
therapy. First dose may
be given before
receiving results
• Observe patient for
signs and symptoms of
anaphylaxis (rash,
pruritus, laryngeal
edema, wheezing).
Discontinue the drug
and notify health care
professional
immediately if these
occur. Keep
epinephrine, an
antihistamine, and
resuscitation equipment
close by in the event of
an anaphylactic
reaction
Name of the Drug Classificat-ion Indication Action Adverse Effects Nursing
Considerat-ions

Piperacillin Sodium ·Use with caution in • Monitor bowel

hepatic or renal failure. function. Diarrhea,
Tazobactam Sodium abdominal cramping,
·Fungal infection  may fever, and bloody stools
2.25 gm TIV q 8hrs x 7 not be prevented by should be reported to
days silver sulphadiazine. health care professional
promptly as a sign of
·Withdraw application pseudomembranous
immediately if signs of colitis. May begin up to
sensitivity like skin several weeks following
rashes appear. cessation of therapy
 
SILVER SULPHADIAZINE CREAM
SILVER SULPHADIAZINE CREAM

Name of the Drug Classificat-ion Indication Action Adverse Effects Nursing

Considerat-ions

Silver Sulphadiazine Antibacterial, ·Used as a topical Silver sulphadiazine  Transient leucopenia – Established infections
Cream        Topical application antimicrobial agent for slowly releases silver decreased granulocyte do not respond well to
the prevention and ions when applied counts 2 – 4 days after silver sulphadiazine.
1 % w/v 100 gm treatment of infection in topically which, together starting treatment. WBC Hence, use as an
burns. with  sulphadiazine levels come back to adjunct to other
2 times a day exerts a bactericidal normal in 4 –5 days. antimicrobial
·Prevention and action. It has a broad Rare effects: measures.        
treatment of infection in spectrum of activity, ·Wide spread
chronic leg ulcers and acting against both ·Burning or stinging applications over
pressure sores. gram positive and gram- sensation and irritation extensive burn areas
negative organisms may occur on may result in significant
·Prophylaxis of infection (including application. absorption of
in skin graft donor sites. pseudomonas). sulphonamide and may
·Hypersensitivity produce the adverse
· Prevention of infection reactions like skin effects of sulpha drugs
in abrasions, laceration necrosis, rashes etc., like agranulocytosis,
and Minor may occur. haemolytic reactions in
  G6PD deficiency,
wounds. Steven Johnson’s
syndrome etc.,
Name of the Drug Classificat-ion Indication Action Adverse Effects Nursing
Considerat-ions

Silver Sulphadiazine   · Use with caution in

Cream  hepatic or renal failure.

1 % w/v 100 gm ·Fungal infection  may

not be prevented by
2 times a day silver sulphadiazine.

·Withdraw application
immediately if signs of
sensitivity like skin
rashes appear.