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A Comparison of The Physical Properties of Some Commercial Aspirin Tablets
A Comparison of The Physical Properties of Some Commercial Aspirin Tablets
A Comparison of The Physical Properties of Some Commercial Aspirin Tablets
Physical Properties of
Some Commercial
Aspirin Tablets
Elaine Armstrong
6-14-02
STEP
Objective
Compare physical properties of
commercially available aspirin
tablets
Methods
Friability
Hardness
Thickness
Disintegration
Weight Variation
Dissolution
Friability Testing
USP test to determine how well tablets will stand
up to coating, packaging, shipping, and other
processing conditions
Ten tablets were dusted and weighed on the analytical
balance
The tablets were placed in the section 1 of the drum of
the friability tester and rotated 100 times
The tablets were re-dusted and re-weighed
According to USP, the tablets should not lose more
than 1% of their total weight
Initial
weight
Final
weight
100
%Loss
Initial
weight
Friability Testing
Hardness
Determine the crushing strength of the
tablets
Using forceps, the 10 tablets were individually
placed between the platens of the hardness
tester
The test button was pushed and the instrument
gave a visual reading of tablet hardness
Thickness
Determines the tablet thickness
Ten tablets were dusted and using forceps
were individually placed between the calipers
of the thickness tester
The instrument gave a visual reading of tablet
thickness
Hardness/Thickness Testing
Weight Variation
Shows the uniformity of tablet weights
Ten tablets were dusted and weighed using the
analytical balance
The mean tablet weight and standard deviation
was calculated
According to the USP, the requirements for
uniformity are met if each individual tablet is
within 85% to 115% of the mean
Disintegration
USP test to determine the time required for
tablets to disintegrate
A 900 mL beaker was filled with 372 C water
Six tablets were placed into the basket-rack assembly
and connected to the disintegration apparatus
The apparatus and the timer were started
simultaneously and the time required for the last tablet
to disintegrate was recorded
Disintegration Testing
Dissolution
The purpose of dissolution testing is to see
how much of the tablet goes into solution
after a given time period
Dissolution Testing
The vessels were added to a circulating
water bath maintained at 37C and allowed
to equilibrate
Once the desired temperature was obtained,
the tablets were added to the mesh
cylindrical baskets and the baskets were
lowered into the vessels and rotated at 50
rpm for 30 minutes.
Dissolution Testing
Dissolution Analysis
A sample was removed from each vessel using a
syringe and then filtered with a 0.45 m nylon
filter
The sample was diluted with buffer and the
concentration was determined by measuring the
absorption at 265 nm using an Ultrospec 3300
pro UV/Visible Spectrophotometer and
comparing to a Standard Curve
Standard Curve
Absorbance (265nm)
y = 3.1353x - 0.017
R2 = 0.9992
0.6
0.4
0.2
0
0
0.05
0.1
0.15
0.2
Concentration (mg/mL)
0.25
0.3
Dissolution Analysis
Results
0.980.18 g
Hardness (average/st.
dev.)
13.561.3 SC
Thickness (average/st.
dev.)
0.1690.002 in
Disintegration (time)
21 sec
-0.14%
Weight Variation
(average/st. dev.)
0.940.02 g
Hardness (average/st.
dev.)
10.121.04 SC
Thickness (average/st.
dev.)
0.170.001 in
Disintegration (time)
17 sec
Dissolution
312.114.8 mg
0.42%
Weight Variation
(average/st. dev.)
0.94.02 g
Hardness (average/st.
dev.)
9.51.01 SC
Thickness (average/st.
dev.)
0.170.001 in
Disintegration (time)
17 sec
Dissolution
263.72.4 mg
0.9%
0.920.01 g
Hardness (average/st.
dev.)
14.142.96 SC
Thickness (average/st.
dev.)
0.170.03 in
Disintegration (time)
8 min 55 sec
Dissolution (average/st.
dev.)
267.9 16.6 mg
0.01%
0.940.01 g
Hardness (average/st.
dev.)
11.181.15 SC
Thickness (average/st.
dev.)
0.1710.002 in
Disintegration (time)
18 sec
Dissolution (average/st.
dev.)
259.92.8 mg
0.12%
0.940.01 g
Hardness (average/st.
dev.)
8.681.06 SC
Thickness (average/st.
dev.)
0.1720.002 in
Disintegration (time)
19 sec
Dissolution (average/st.
dev.)
251.46.4 mg
0.39%
0.930.01 g
Hardness (average/st.
dev.)
13.811.9 SC
Thickness (average/st.
dev.)
0.1710.001 in
Disintegration (time)
26 sec
Dissolution (average/st.
dev.)
2705.6 mg
Bayer Aspirin
Distributed by the
Bayer Corporation
Morristown,NJ
07962-1910
Cost:$3.99
Expires: 1-04
Lot #: 241812B
0.01%
Weight Variation
(average/st. dev.)
0.950.01 g
Hardness (average/st.
dev.)
9.830.91 SC
18 sec
Dissolution
(average/st. dev.)
254.16 mg
0.93%
0.930.01 g
Hardness (average/st.
dev.)
16.151.41 SC
Thickness (average/st.
dev.)
0.1710.002 in
Disintegration (time)
19 sec
Dissolution (average/st.
dev.)
280.118.1 mg
Overall Results
Friabilit Weight
y
Variation
(% Loss)
(g)
Lite Coat
0.34
0.98
13.56
0.169
21
247.5
Equate
-0.14
0.94
10.12
0.170
17
312.1
CVS
0.42
0.94
9.50
0.170
17
263.7
Bookstor
e
0.90
0.92
14.14
0.170
535
267.9
Kroger
0.01
0.94
11.18
0.171
18
259.9
Target
0.12
0.94
8.68
0.172
19
251.4
K-Mart
0.39
0.93
13.80
0.171
26
270.0
Bayer
0.01
0.95
9.83
0.174
18
254.1
Pharmacy
School
0.93
0.93
16.15
0.171
19
280.1
Conclusions
Summary
The tablets all met USP standards for friability
The tablets displayed uniformity in terms of
hardness, thickness, and weight variation
With the exception of the tablets obtained from
the bookstore, all tablets disintegrated within 30
seconds
Five of the nine lots tested passed USP standards
for dissolution