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Membrane Assisted Crystallization
Membrane Assisted Crystallization
Membrane Assisted Crystallization
MEMBRANE ASSISTED
CRYSTALLIZATION
Prepared by :
Upasana Wadhwani
Guided by :
Dr. Bina Sengupta
INTRODUCTION
Crystallization is one of the oldest important separation and
purification process.
The crystallization process consists of two major events, nucleation
and crystal growth.
Supersaturation is the driving force for crystallization.
As a result crystals of different shapes and sizes are obtained.
The control of crystal size and shape constitutes one of the major
challenges in industries.
The interest in combining membrane operations and solution
crystallization is motivated by the aim to develop more efficient
crystallization processes.
Membranes, with their intrinsic characteristics of efficiency and
operational simplicity leads to significant innovation in both
processes and products.
Herman Kramer-Influence of solubility characteristics on experimental application and energy saving potential from
http://www.academia.edu/13279506/Membrane-assisted-crystallization
WHY MEMBRANES ?
Membranes are used due to their following properties:
Operational simplicity
High selectivity
Permeability for the transport of specific components
Compatibility between different membrane operations in integrated
systems
Low energetic requirement
Good stability under operating conditions
Environmental compatibility
Easy control and scale-up
Large operational flexibility
Enrico Drioli, Gianluca Di Profio, Efrem Curio. Membrane-Assisted Crstallization Technology-Vol 2;2013.
though the membrane in the liquid state allows the formation of a double
liquid/vapor interface on both the sides of the membrane.
A gradient of chemical potential between these two interfaces, due to a temperature
and/or concentration differences, is the driving force of the overall process.
Di Profio-Membrane crystallization technology: heterogeneous nucleation above the membrane surface from
http://www.itm.cnr.it/index.php/en/staff-2/2-non-categorizzato/95-highlights-di-profio-2
Enrico Drioli, Gianluca Di Profio, Efrem Curio. Membrane-Assisted Crstallization Technology-Vol 2;2013.
MEMBRANE ASSISTED
CRYSTALLIZATION
Enrico Drioli, Gianluca Di Profio, Efrem Curio. Membrane-Assisted Crstallization Technology-Vol 2;2013.
Enrico Drioli, Gianluca Di Profio, Efrem Curio. Membrane-Assisted Crstallization Technology-Vol 2;2013.
MEMBRANE DISTILLATION
Membrane distillation is a thermally driven process.
The hydrophobic nature of the membrane prevents the passage of
crystallization.
Stabile C,Caridi A,Curcio E, Drioli E.-Antisolvent membrane crystallization of pharmaceutical compounds.-J Pharm Sci.2009 Dec
10
SCHEME 2
The antisolvent and the solvent are miscible.
A vapor pressure is generated between the two sides of the membranes by a
temperature difference
The solvent having higher vapor pressure, evaporates at a higher rate, thus
producing a certain degree of solvent/antisolvent demixing.
As the fraction of antisolvent in the mixture increases from the initial
composition, the lower solubility of the solute generates supersaturation and
a phase separation occurs.
Stabile C,Caridi A,Curcio E, Drioli E.-Antisolvent membrane crystallization of pharmaceutical compounds.-J Pharm Sci.2009 Dec
11
APPLICATIONS
[1] Ye, J. Lin, J. Shen, P. Luis, B. Van der Bruggen, "Membrane Crystallization of Sodium Carbonate for Carbon Dioxide Recovery
vol. 13, 2013;23622372
[2] Hajduk PJ and Greer J. A decade of fragment-based drug design: Nat Rev Drug Discov. 2007; 6:211-219 2005; 1171-1176.
[3] Konig A and Weckesser D. Membrane based evaporation crystallization
12
THANK YOU